School of Biological and Chemical Sciences, Queen Mary University of London, London, UK Subdepartment of Animal Behaviour, Department of Zoology, University of Cambridge, Cambridge, UK National Institute of Child Health and Human Development, molecular Medicine Program, Bethesda, MD 20892, USA Division of Pediatric Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA Department of Medicine, Washington University School of Medicine Department of Pathology, University of Cincinnati College of Medicine, USA Department of Ancient Egypt and Sudan, The British Museum, Great Russell Street, London WC1B 3DG, UK School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK Centre for Infectious Diseases and International Health, University College London Kuvin Centre for the Study of Infectious and Tropical Diseases, The Hebrew University, Hadassah Medical School, PO Box 12272, Jerusalem 91120, Israel Arc-Epidemiology Unit, Stopford Building, The University of Manchester, Manchester, UK University of Oxford Institute of Musculoskeletal Sciences, Botnar Research Centre, Oxford OX3 7LD, UK Bone Research Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, UK National Laboratory of Medical Genetics, Central South University, Changsha, Hunan, China Institute for Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA Kinki University School of Medicine, Japan Department of Genome Sciences, University of Washington, Seattle, Washington 98195-5065, USA McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA Department of Human Biology, Faculty of Medicine, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia Department of Paediatrics, First Affiliated Hospital, Xi'an Jiaotong University, Peoples' Republic of China Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK Cardiovascular Biology Group, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK Cardiovascular Group, School of Clinical and Laboratory Sciences, University of Manchester, Grafton Street, Manchester M13 9NT Department of Systematic and Evolutionary Botany, Faculty Centre for Biodiversity, University of Vienna, Rennweg 14, 1030 Vienna, Austria Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK Universitatskliniken des Saarlandes, Klinik fur Innere Medizin III, Homburg/Saar, Germany Department of Medicine, State University of New York Downstate Medical Center, Brooklyn and New York, NY 10128-1152 Hospital Amphia Ziekenhuis, loc. 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and Environment, University College London, London WC1E 6BT, UK Marine Institute, Plymouth University, Plymouth PL4 8AA, UK Cleveland Clinic Lerner School of Medicine, Case Western Reserve University Taussig Cancer Institute - Cleveland Clinic, Cleveland, OH, USA Department of Biochemistry and Molecular Biology, 1870 Campus Delivery, Colorado State University, Fort Collins, CO 80523-1870, USA Polytrauma Treatment Team, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA Department of Neurology, Case Western Reserve University, Cleveland, Ohio 44106, USA Neurology Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106 Health Psychology Section, Psychology Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA Department of Pulmonary Medicine, Inselspital, University Hospital and University of Bern, Bern, CH-3010, Switzerland Department of Pulmonary Medicine, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover, D-30625, Germany Metabolic Bone Unit, Department of Internal Medicine, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy Department of Neurology, St Mary's Hospital, Imperial Healthcare NHS Trust, London, W2 1PD, UK Department of Clinical Chemistry, Charing Cross Hospital, Imperial Healthcare NHS Trust, London, W6 8RF Department of Undergraduate Medicine, Imperial College London, SW7 2AZ Department of Medicine, Staten Island University Hospital, 27 Hickory Avenue, NY 10305, USA UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK Department of Anesthesia and Intensive Care Medicine, Haukeland University Hospital, 5021 Bergen, Norway Department of Physical Medicine and Rehabilitation, Firat University, Faculty of Medicine, 23119 Elazig, Turkey Hospital de Curry Cabral - Department of Pathology - Rua da Beneficência nº 8 1069-166 Lisboa, Portugal Hospital de Curry Cabral - Department of Internal Medicine I - Rua da Beneficência nº Portugal Center for Conservation Biology (Department of Biology) and Woods Institute for the Environment, Stanford University, 371 Serra Mall, Stanford, CA 94305-5020, USA Natural Capital Project, Woods Institute for the Environment, Stanford University, 371 Serra Mall, Stanford, CA 94305-5020, USA Department of Medicine and Health, Faculty of Health Sciences, Linköping University, Linköping and Stockholm Heart Center, Bergviksvägen 48, SE-167 63 Bromma, Sweden Department of Medicine, University College Hospital, Ibadan, Nigeria Department of Pathology, University College Hospital, Ibadan, Nigeria Department of Surgery, University College Hospital, Nigeria Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran 14197, Iran Department of Medicine, Division of Infectious Diseases, Island University Hospital, USA Department of Pathology, B P Koirala Institute of Health Sciences, Dharan, Nepal Department of Surgery, B P Koirala Institute of Health Sciences, Dharan, Nepal Department of Medicine, Goulburn Valley Health, Graham Street, Shepparton, Vic 3130 Division of Oncology, Department of Internal Medicine, E-Da Hospital/I-Shou University, 1, E-Da Road, Jiau-shu Tsuen, Yan-chau Shiang, Kaohsiung county 82445, Taiwan Department of Pathology, E-Da Hospital/I-Shou University, 1, E-Da Road, Jiau-shu Tsuen, Yan-chau Shiang, Kaohsiung county 82445, Taiwan Division of Hepatogastroenterology, Department of Internal Medicine, E-Da Hospital/I-Shou University, 1, E-Da Road, Jiau-shu Tsuen, Yan-chau Shiang, Kaohsiung county 82445, Taiwan Department of Radiology, E-Da Hospital/I-Shou University, 1, E-Da Road, Jiau-shu Tsuen, Yan-chau Shiang, Kaohsiung county 82445, Taiwan Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK De Ruiter Seeds, PO Box 1050, 2660 BB, Bergschenhoek, The Netherlands Laboratory of Plant Breeding, Wageningen University, PO Box 386, 6700 AJ Wageningen, The Netherlands Department of Anesthesiology, Messologi General Hospital, Messologi, 30100, Greece Department of Interventional Radiology, University of Patras Medical School, Rion, Patras 26500, Greece Department of Surgery, Messologi General Hospital, Greece Institute of Biomedicine, University of León, Campus Universitario, 24071, León, Spain Pathology Department, Complejo Hospitalario León, c/Altos de Nava s/n, 24071, León, Spain Gastroenterology Unit, Complejo Hospitalario León, Spain School of Medicine, Aga Khan University, P. O. Box 3500, Stadium Road, Karachi, Pakistan Department of Neurosurgery, University of New Mexico Albuquerque Department of Neurosurgery, King Fahd Specialists Hospital, Al-Qassim, Saudi Arabia National Institute of Oncology, IbnSina University Hospital Institute, Rabat, Morocco Department of Urology, Hassan II University Hospital Institute, Morocco Department of Histopathology, Hassan II University Hospital Institute, Fez, Morocco Department of Pathology, Derby City General Hospital, Uttoxeter Road, Derby, Derbyshire, DE22 3NE Department of Colorectal Surgery, Derby City General Hospital, Uttoxeter Road, Derby, Derbyshire, DE22 3NE, UK Department of General, Visceral, Vascular and Transplant-Surgery, Julius-Maximilians-University of Würzburg, Würzburg, Germany Department of Radiology, University of Ilorin Teaching Hospital, Ilorin, Nigeria Department of Surgery, Division of General Surgery, University of Ilorin Teaching Hospital, Ilorin, Nigeria Hepatology, School of Digestive and Liver Diseases, I. P. G. M. E. R, Kolkata 700020, West Bengal, India Division of Surgical Gastroenterology, School of Digestive and Liver Diseases, I. P. G. M. E. R, Kolkata 700020, West Bengal, India Department of Cardiac Surgery, Spedali Civili Brescia, P. le Spedali Civili, 1- Italy Department of Applied Experimental Medicine, Section of Cardiovascular Disease, Brescia Study University, P. le Spedali Civili, 1-Brescia, Italy Department of Radiology, Faculty of Medicine, Fluminense Federal University, Rua Marquês do Paraná, 303. CEP 24. 033. 900. Niterói. Rio de Janeiro, Brazil Service of Diagnostic Radiology, Clementino Fraga Filho Universitary Hospital, Rua Prof. Rodolpho Paulo Rocco, 225. CEP 21. 941. 913. Cidade Universitária. Rio de Janeiro, Brazil Life Science Trace Gas Facility, Institute of Molecules and Materials, Radboud University Nijmegen, Nijmegen, 6525 AJ Department of Ecogenomics, Institute for Water and Wetland Research (IWWR), Radboud University Nijmegen, Nijmegen, 6525 AJ, The Netherlands Systems and Structural Biology Center (SSBC), Yokohama Institute, RIKEN, Yokohama-shi, Kanagawa 230-0045, Japan Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako-shi, Saitama 351-0198, Japan Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033 Cellular Dynamics Laboratory, Discovery Research Institute, RIKEN, Wako-shi, Saitama 351-0198, Japan INSERM, Equipe de Recherche Methodologique (ERM) 0107, Bron 69677, France Research Institute of Pharmaceutical Sciences, Musashino University Nishitokyo-shi, Tokyo 202-8585, Japan Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, Yokohama 226-8502, Japan Department of General Surgery, University Hospital of Heraklion, Medical School of Crete, Heraklion, Greece Department of Radiology, University Hospital of Heraklion, Medical School of Crete, Heraklion, Greece Department of General Surgery, Shri Maharaja Hari Singh Medical College, Karanagr, MS, Srinagar, Kashmir, 190011, India Department of Cardiothoracic and Vascular Surgery, Sheri Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, 190011, India Department of Cardiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Iran Department of General Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Department of Internal Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Department of Psychiatry, Federal Medical Centre, PMB 3031 Sapon, Abeokuta, Ogun State, Nigeria Department of Medicine, Federal Medical Centre, PMB 3031 Sapon, Abeokuta, Ogun State, Nigeria Department of Medicine, Galway University Hospital, Newcastle Road, Galway, Ireland Department of Surgery, Galway University Hospital, Newcastle Road, Galway, Ireland Department of General Surgery, Eskisehir Osmangazi University Faculty of Medicine, Meselik Campus, 26480 Eskisehir, Turkey Department of Thoracic and Cardiovascular Surgery of Johann Wolfgang Goethe University Hospital, Theodor-Stern-Kai 7, 23A, 60590, Frankfurt am Main/Germany Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 1NG, UK Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870, USA Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N3Z5 Department of Medicine, SUNY Upstate Medical University, 750 E Adams Street, Syracuse, NY, 13210, USA Respiratory Department, Aristotle University of Thessaloniki Gastroenterological Department, G. Papanikolaou General Hospital, George Papanikolaou Str, Thessaloniki, 57010 Department of Medicine, The Aga Khan University, Stadium Road, Karachi, 74800, Pakistan Medical College, The Aga Khan University, Stadium Road, Karachi, 74800, Pakistan Department of Internal Medicine A and Laboratory of Kidney Pathology 02, Charles Nicolle Hospital, Boulevard 9 Avril. 1006 Tunis, Tunisia Department of Radiology, University of Pisa, Via Roma 67, 56100 Pisa, PI, Italy Department of Surgery, University of Pisa, Via Roma 67, 56100 Pisa, PI, Italy Department of General Internal Medicine, University of Alabama at Birmingham, (1530 3rd Ave. South), Birmingham, (35294-3407), USA Radiology Department of University Hospital of Coimbra, Praceta Prof. Mota Pinto 3000-075 Coimbra, Portugal Obstetrics Department of University Hospital of Coimbra, Rua Miguel Torga, 3030-165, Coimbra, Portugal Department of Pediatrics, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy Department of Plastic and Reconstructive Surgery, Soft Tissue Tumour Reference Centre, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle-de-la Camp Platz 1, 44789 Bochum Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA Department of Biology, Duke University, PO Box 90338, Durham, NC 27708 Department of Mathematics, Duke University, PO Box 90230, Durham, NC 27708, USA Department of Radiology, Mustafa Kemal University, Faculty of Medicine, Hatay, Turkey Department of General Surgery, Mustafa Kemal University, Faculty of Medicine, Antakya, Hatay, Turkey Department of Critical Care Medicine, Zhong-Da Hospital, Southeast University Clinical Medical School, Nanjing 210009, Jiangsu Province, China CRUK Cambridge Research Institute, Li Ka Shing Centre, UK Strangeways Research Laboratory, Cancer Research UK Department of Oncology, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street, London, WC1E 6BT, UK Department of Clinical & Molecular Genetics, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK Department of Biological Sciences, University of Essex, Colchester CQ4 3SQ, Essex, UK MRC Centre for Nutrition in Cancer Epidemiology Prevention and Survival, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK Epidemiology Research Program, American Cancer Society, Atlanta, GA Risk Sciences International, Ottawa, ON, Canada Department of Radiologic Technology, School of Health Sciences, Kyushu University, Fukuoka, Japan Department of Radiology, Fukuoka University School of Medicine, Fukuoka, Japan Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Center for Conservation and Sustainable Development, Missouri Botanical Garden, USA Department of Environmental Science, Policy and Management, University of California, 130 Mulford Hall, Berkeley, CA 94720, USA Museum of Vertebrate Zoology, University of California, 3101 Valley Life Sciences, Berkeley, CA 94720, USA Department of Nuclear Medicine, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria Institute of Pathology, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria Department of Radiology, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria Department of Pulmonology, Natters Hospital, In der Stille 20, 6161 Natters Department of Oncology, Natters Hospital, In der Stille 20, 6161 Natters Department of Cardiac Surgery, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria Department of Surgery, University of Virginia Health Services, Charlottesville, VA, USA Medical College, The Aga Khan University, Pakistan Department of Pediatrics and Child Health, The Aga Khan University, (Stadium Road), Karachi, 74800, Pakistan Department of Internal Medicine, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA Department of Neuroscience, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA Department of Pulmonary Diseases, Kirikkale University School of Medicine, 71100, Kirikkale, Turkey Department of Urology, Kirikkale University School of Medicine, Kirikkale, Turkey Department of Pathology, Kirikkale Yuksek Ihtisas Hospital, 71400, Kirikkale, Turkey Department of Respiratory Medicine, Ataturk Chest Disease and Surgery Center, 06280, Ankara, Turkey Department of Clinical Microbiology, Kirikkale University School of Medicine, 71100, Kirikkale Department of Clinical Sciences, Lund University Diabetes Centre, CRC, Scania University Hospital, Malmo, Sweden Department of Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, District, Wardha - 442102, Maharashtra, India Department of General Surgery, Gandhi Medical College and Associated Hospitals, Bhopal-462001, Madhya Pradesh, India Department of Pathology, Soft Tissue Tumour Reference Centre, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle-de-la- Camp-Platz 1, 44789 Bochum, Germany Department of Plastic and Reconstructive Surgery, Department of Hand Surgery, Soft Tissue Tumour Reference Centre, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle-de-la Camp-Platz 1, 44789 Bochum, Germany Department of Ophthalmology, Farabi Eye Research Center, South Kargar Street, Tehran, Postal code: 1336616351, Iran Department of Intensive Care unit, Shandong University Qilu Hospital, Jinan, Shandong, 250012, China Department of Radiology, Shandong University Qilu Hospital, Jinan, Shandong, 250012, China Plastic Surgery Department, Interbalcan Medical Center, Thessaloniki, Greece Fourth Surgical Department, Aristotle University of Thessaloniki, Greece Diagnostic Radiology Department, General Rethymnon Hospital, Rethymno 74100, Greece Diagnostic Radiology Department, Interbalcan Medical Center, Thessaloniki, 55236, Greece Radiologic Department, Aristotle University of Thessaloniki, Macedonia, 55236, Greece Department of General Surgery, South Tyneside NHS Foundation Trust, Harton Lane, South Shields, South Tyneside, NE34 0PL, UK Department of Surgical Gastroenterology, Sri Ramachandra Medical College & Research Institute, Sri Ramachandra University, Porur, Chennai, 600116, Tamil Nadu, India Surgery Unit Clinique Chirurgicale C, University Hospital Ibn Sina, Rabat, Morocco Department of Internal Medicine, Hiroshima City Hospital, 7-33, Moto-machi, Naka-ku, Hiroshima-city, Hiroshima, 730-8518 Brigham and Women's Hospital, Boston, MA, 75 Francis St, Boston, MA 02115, USA Massachusetts General Hospital, Boston, MA, 55 Fruit St, Boston, MA 02114, USA Mount Sinai School of Medicine, One Gustave L. Levy Place - Box 1079 New York, NY 10029, USA Department of General Surgery, Leighton Hospital, UK Department of Pathology, Laiko General Hospital, Athens Medical School, 17 Agiou Thoma str, 11527, Goudi, Athens, Greece Department of Surgery, Laiko General Hospital, Athens Medical School, 17 Agiou Thoma str, 11527, Goudi, Athens, Greece Department of Urology, Laiko General Hospital, Athens Medical School, 17 Agiou Thoma str, 11527, Goudi, Athens, Greece Department of Biology and IGSP Center for Systems Biology, Duke University, Durham, NC 27708, USA GrassRoots Biotechnology, 302 E Pettigrew Street, Suite A200, Durham, NC 27701 Departamento de Oncologia, Hospital da Cidade de Passo Fundo, Rua Tiradentes, 295 - Passo Fundo/RS - Cep 99010-260, Brasil Department of Plastic Surgery, Wexham Park Hospital, UK Department of Health Psychology, Aston University, Birmingham, UK Department of Biology, McGill University, 1205 Avenue Docteur Penfield, Montreal, Quebec H3A 1B1, Canada University of Valencia Medical School, Avda Blasco Ibanez 15, Valencia 460101, Spain Department of General Medicine, Emory University School of Medicine 69 Jesse Hill Jr, Drive, S. E. Atlanta, GA 30303, USA Department of Haematology, University College Hospital, Galway, Ireland Department of Gastroenterology, University College Hospital, Galway, Ireland Department of Neurology, Nuremberg Municipal Academic Hospital, Breslauerstrasse 201, 90471 Nuremberg, Germany Department of Nephrology and Hypertension, University Hospital Erlangen-Nuremberg Department of Pediatric Nephrology, Dr. Gharib Ave. Keshavarz Blvd. , Children's Hospital Medical Center, Tehran University of Medical Sciences, 14114, Tehran Department of Nuclear Medicine, Dr. Gharib Ave. Keshavarz Blvd. , Children's Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran Research Institute for Nuclear Medicine, Tehran University of Medical Sciences, Shariati Hospital, North Kargar Ave. 14114, Tehran, Iran Department of Clinical Science at South Bristol (Obstetrics and Gynaecology), University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK Department of Veterinary Basic Science, Royal Veterinary College, Royal College Street, London NW1 0TU Department of Biochemistry and Molecular Biology, Royal Free and University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK Division of Endocrine Surgery, Department of Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213 Department of Radiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Neurology, Academic Medical Center, University of Amsterdam, 1100 DD, Amsterdam, The Netherlands Department of Neurology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, Iowa, 52246, USA Department of Physical Therapy, University of Iowa Carver College of Medicine, Iowa City, Iowa, 52246 Performance Therapies, PC, Ridgeway Drive, Coralville, Iowa, USA Division of General Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, Iowa, 52246, USA Center for Research in the Implementation of Innovative Strategies in Practice (CRIISP) VA HSR&D Center of Excellence, Iowa City VA Medical Center, USA Veterans Administration (VA), Iowa City VA Medical Center, 601 Highway 6 West, Iowa City, Iowa, 52246, USA The Department of Radiology, Barnsley District General, Gawber Road, Barnsley, South Yorkshire, S75 2EP, UK The Medical School, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK Research Assistant, Department of Periodontology, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey DDS, PhD, Private Practice, Ankara, Turkey School of Education, University of Birmingham, UK Department of Emergency Medicine, Military Hospital, Peshawar Road, Rawalpindi-51000, Pakistan Department of Dermatology, PAF Hospital Faisal, Karachi-8, Pakistan Department of Dermatology, Combined Military Hospital, Pakistan Department of Ear, Nose and Throat Surgery, Federal Medical Center, Gombe, Gombe State, Nigeria Department of Surgery, Otorhinolaryngology Unit, Jos University Teaching, Hospital, PMB 2076, Jos, Plateau State, Nigeria Department of Nephrology, Hospital São João, Alameda Prof. Hernâni Monteiro, 4200 - 319 Porto, Portugal Department of Internal Medicine, Hospital São João, Alameda Prof. Hernâni Monteiro, 4200 - 319 Porto, Portugal Department of Hygiene and Epidemiology, University of Porto Medical School, Alameda Prof. Hernâni Monteiro, 4200 - 319 Porto Department of Urology, Singapore General Hospital, Singapore, Singapore 169608, Republic of Singapore Department of Pathology, Singapore General Hospital, Singapore, Singapore 169608, Republic of Singapore Department of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Republic of Singapore NCCS-VARI Laboratory of Translational Cancer Research, Singapore, Republic of Singapore Department of Cardiothoracic Surgery, National Heart Centre, Singapore 168752 Department of Cardiothoracic Surgery, Northern General Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield, S5 7AU, UK NHS Hammersmith and Fulham PCT, 4th Floor, Hammersmith Town Hall Extension, King Street, London, Greater London, W6 9JU, UK Department of Radiology and Imaging, Imam Khomeini Hospital, Keshavarz Boulevard, Medical Sciences/Tehran University, Tehran Department of Pathology, University of Pisa, Via Roma 67, 56126 Pisa, Italy Department of Surgery, University of Pisa, Italy Department of General Surgery, Universitet Hospital Hassan II, Fes Department of Surgery & Biological Sciences, The Aga Khan University Hospital, Stadium road, 3500, Karachi, 74800, Pakistan Department of Neurosurgery, The Aga Khan University Hospital, Stadium road, 3500, Karachi, 74800, Pakistan Department of Rheumatology, Wrightington Hospital, Hall Lane, Appley Bridge, Wigan, Lancashire, WN6 9EP Department of Orthopaedics, Wrightington Hospital, Hall Lane, Appley Bridge, Wigan, Lancashire, WN6 9EP, UK Department of Clinical Research, Wrightington Hospital, Hall Lane, Appley Bridge, Wigan, Lancashire, WN6 9EP, UK Orthopaedic Hospital of Speising, Paediatric Department, A-1130 Vienna, Speisinger Str. 109, Austria School of Medicine, University of Milan, Via Festa del Perdono 7, 20122 Milano, Italy Energy Biosciences Institute, University of California Berkeley, Berkeley CA 94720, USA Department of Orthopaedics and Sports Medicine, North Sydney Orthopaedic and Sports Medicine Centre, 286 Pacific Highway, Crows Nest, Sydney, NSW 2065, Australia Department of Trauma and Orthopaedics, Epsom General Hospital, Dorking Road, Epsom, Surrey, KT18 7EG, UK Department of Plastic and Reconstructive Surgery, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir Department of Gastroenterology, Hinchingbrooke Health Care NHS Trust, Hinchingbrooke Hospital, UK Peninsula College of Medicine and Dentistry Neurology Department, Derriford Hospital, Derriford Road, Plymouth PL6 8DH, UK Neurology Department, Torbay Hospital, Torquay TQ2 7AA, UK Department of Primary Care and Public Health, Imperial College London, London, UK Imperial College Centre for Patient Safety and Service Quality, UK Department of Pancreatobiliary Surgery, University Hospital of Wales, Cardiff CF14 4XW, UK Department of Physiology, Clinical Unit, University of Ioannina Medical Faculty, 13 Solomou Street 452 21 Ioannina, Greece Department of Medicine and Pulmonary Diseases, Grevena State Hospital, 51100 Grevena, Greece School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK Department of Diagnostic Radiology, Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK Department of Medicine, University College of Medical Sciences, Delhi 110001, India Department of Radiology, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark Department of Anaesthesia and Intensive Care Unit, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark Department of Pediatric Surgery, Helen DeVos Children's Hospital, 330 Barclay Avenue NE, Suite 202, Grand Rapids, MI 49503, USA Grand Rapids Medical Education Center Pediatric Residency Program, Michigan State University, Helen DeVos Children's Hospital, 330 Barclay Avenue NE, Suite 300, Grand Rapids, MI 49503, USA Pathology Department, Theagenion Oncologic Hospital, Alexandros Symeonidis Str. 2, 54007 Thessaloniki, Greece ENT, Head & Neck Surgery Clinic, Theagenion Oncologic Hospital, Alexandros Symeonidis Str. 2, 54007 Thessaloniki, Greece The Howard Hughes Medical Institute, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA Department of Orthopaedic Surgery, Juntendo University Shizuoka Hospital, Izunokuni City, Shizuoka 410-2295, Japan Accident and Emergency Department, Colchester University Hospital NHS Foundation Trust, Colchester- CO4 5JL Department of General Surgery/Accident and Emergency, Sheri-Kashmir Instuite of Medical Sciences, Srinagar, Kashmir, India Department of Structural Biology and Genomics, Institut de Ge´ ne´ tique et de Biologie, Mole´ culaire et Cellulaire (IGBMC), Universite´ Louis Pasteur de Strasbourg, France Children's Hospital, Harvard Medical School, Boston, USA Department of Cardiac Surgery, Chest Disease Hospital, Al-Jabriah, Kuwait Department of Orthopaedic Surgery, 12 Octubre Hospital, Av. Córdoba, s/n Madrid, 28041 Department of Radiology, University Hospital Rigshospitalet, DK-2100 Copenhagen, Denmark Centre of Inflammation and Metabolism, Department of Infectious Diseases, University Hospital Rigshospitalet, section M7641, DK-2100 Copenhagen, Denmark Department of Cardiology, University Hospital Rigshospitalet, DK-2100 Copenhagen Department of Cardiothoracic Surgery, University Hospital Rigshospitalet, DK-2100 Copenhagen, Denmark Department of Ophthalmology, James Paget University Hospital NHS Foundation Trust, Lowestoft Road, Gorleston Norfolk, NR31 6LA, UK Department of ENT, Diagnostic and Therapeutic Medical Center Medicina, Barska 12, 30-307 Krakow, Poland Department of Histology, Jagiellonian University, Medical College, Kopernika 7, 31-034, Krakow, Poland Radiology Department, 401 General Army Hospital of Athens, Greece Department of Orthopaedic, Shoulder and Knee Arthroscopy Division, Central Clinic of Athens, Asklipiou, 31 Str, 106-80, Greece Department of Pathology, Cambridge Health Alliance, 1493 Cambridge Street, Cambridge, MA 02139, USA Department of Pulmonary and Critical Care, Cambridge Health Alliance, 1493 Cambridge Street, Cambridge, MA 02139 Department of Medicine, Cambridge Health Alliance, 1493 Cambridge Street, Cambridge, MA 02139, USA Harvard Medical School, USA Hematology/Oncology Unit, Massachusetts General Hospital, 32 Fruit Street, Yawkey 7A, Boston, MA 02114, USA Endocrine Department, National Institutes Of Health, Bethesda, Maryland, 20815, USA Urology Department, Kamkar Hospital, AZAD Medical Sciences University, School of Medicine, Qom Urology Department, Kamkar Hospital, Qom Medical Sciences University, School of Medicine, Qom, Iran Department of Medical Oncology at National Institute of Oncology, Rabat, Morocco Department of Anatomical Pathology, Ibn Sina University Hospital, Rabat, Morocco Department of Thoracic Surgery, Ibn Sina University Hospital, Rabat, Morocco Department of Thoracic Surgery, Hassan II University Hospital, Fes, Morocco Gastrointestinal Endoscopy Unit, Democritus University of Thrace, University General Hospital, Dragana, Greece Department of Neurosurgery, Democritus University of Thrace, University General Hospital, Dragana, 68100 Alexandroupolis, Greece Radiology Department, Democritus University of Thrace, University General Hospital, Dragana, 68100 Alexandroupolis, Greece Department of Neurology, Hospital, Calzada de Tlalpan 4800, Colonia Sección XVI, Tlalpan, C. P. 14080. Distrito Federal, México Department of Ophthalmology, Calzada de Tlalpan 4800, Colonia Sección XVI Department of Internal Medicine, Calzada de Tlalpan 4800, Colonia Sección XVI, Tlalpan, C. P. 14080. Distrito Federal, México Division of Pathology (Diagnostic Molecular Pathology Unit), Kobe University Graduate School of Medicine Institute of Biology, University of Southern Denmark, 5230 Odense M, Denmark Department of Biology, University of Western Ontario, London, Ontario, Canada N6A 5B7 Department of General Surgery, Bradford Royal Infirmary, Bradford, BD9 6RJ, UK Department of Radiology, Bradford Royal Infirmary, Bradford, BD9 6RJ, UK Department of General Surgery, Bradford Royal Infirmary, Bradford, BD9 6RJ, UK Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan Faculty of Health Science, Suzuka University of Medical Science, Suzuka, Japan Department of Pathology, University of Leicester, Robert Kilpatrick Building, Leicester Royal Infirmary, PO Box 65, Leicester LE2 7LX, UK Department of General Surgery, University Hospitals of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK Division of Surgery, Kobe 100 Years Memorial Hospital, 1-9-1 Misaki-cho, Hyogo-ku, Kobe 652-0855, Japan Division of Urology, Kobe 100 Years Memorial Hospital, 1-9-1 Misaki-cho, Hyogo-ku, Kobe 652-0855, Japan Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cyo, Chuo-ku, Kobe 650-0017, Japan Department of Dermatology and Venereology, 1, Georgi Sofiiski str, 1431 Sofia, Bulgaria Department of Neurology, 1, Georgi Sofiiski str, 1431 Sofia, Bulgaria Department of Physiology and Pharmacology, Preclinical Veterinary School, Microvascular Research Laboratories, Bristol Heart Institute, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK Department of Radiology, University of Brescia, Piazzale Spedali Civili 1, 25124, Italy Department of Cardiology, University of Brescia, Piazzale Spedali Civili 1, 25124 Department of Orthopaedic and Trauma Surgery, Insubria University, Viale Borri 57, 21100 Varese Department of Gastroenterology, University Hospitals Leuven, Herestraat 49 - B3000 Leuven, Belgium Department of Surgery, Princess Royal University Hospital, Orpington, BR6 8ND, UK Radiology Department, University General Hospital of Alexandroupolis, Dragana, 68100 Alexandroupolis, Greece Microbiology Laboratory, University General Hospital of Alexandroupolis, Dragana, 68100 Alexandroupolis, Greece Paediatric Surgery Department, University General Hospital of Alexandroupolis, Dragana, 68100 Alexandroupolis, Greece Department of Nuclear Medicine, Düzce University, School of Medicine, Konuralp, Düzce, 81620, Turkey Department of General Surgery, Düzce University, School of Medicine, Konuralp, Düzce, 81620, Turkey IVI Castello´ n, Castello´ n 12004, Spain CEFIVA, Oviedo 33011, Spain FIVAP, Santa Cruz de Tenerife 38204, Spain IBILAB, Palma de Mallorca 07011, Spain IVI Alicante, Alicante 03015, Spain IVI Madrid, Madrid 28023, Spain GINEMED, Sevilla 41001, Spain Health Economics and Outcomes Research, Merck, S. L. (an affiliate of Merck KGaA, Darmstadt, Germany), Maria de Molina, 40, 28006 Madrid, Spain Laboratory of Experimental Medicine, Universite´ Libre de Bruxelles, B-1070 Brussels, Belgium Department of Pathology, Medical University of Warsaw, 5 Chalubinskiego Street, 02-004 Warszawa, Poland Department of Gastroenterology, Diabetes and Internal Medicine, Medical University of Warsaw, 1a Banacha Street; 02-097 Warsaw, Poland Department of Nephrology, Dialysis Therapy and Internal Medicine, Medical University of Warsaw, 1a Banacha Street, 02-097 Warsaw, Poland Department of Nephrology, Institute of Transplantology, Medical University of Warsaw, 59 Nowogrodzka Street, 02-006 Warszawa, Poland Department of Radiology, Democritus University of Thrace, University General Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece Endoscopy Unit, Democritus University of Thrace, University General Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece Department of Gastroenterology and Hepatology, Military General Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece Nuclear Medicine Division, Radiology Department, Medical Science School, University of Campinas, Campinas, S. P. , Brazil Endocrinology Division, Internal Medicine Department, Medical Science School, University of Campinas, Campinas, S. P. , Brazil Department of Neurology, Zurich University Hospital, 8091 Zurich, Switzerland Department of ENT- HNS, Zurich University Hospital, 8091 Zurich, Switzerland Next Generation Sequencing Group, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany Deep Sequencing Group - SFB655, Biotechnology Center TU Dresden, Tatzberg 47-49, 01307 Dresden, Germany Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany Department of Nutrition, University of California at Davis, CA, USA A' Laboratory of Pathologic Anatomy, Agiou Thoma 17, 115 27 Goudi, Laiko General Hospital, Medical School, University of Athens, Greece Second Department of Propedeutic Surgery, Agiou Thoma 17, 115 27 Goudi, Laiko General Hospital, Medical School, University of Athens, Greece Department Of General Surgery, Queen Elizabeth II Hospital, UK Division of Neuroradiology, Department of Radiology, Texas Children's Hospital, Baylor College of Medicine, 6621 Fannin Street, Houston, Texas 77030, USA Neuro-Spine Center, Division of Pediatric Neurosurgery, Department of Neurosurgery, Texas Children's Hospital, Baylor College of Medicine Department of Surgery, Queen Mary's Hospital, Sidcup, Kent DA146LT, UK Department of Radiology, 424 Military General Hospital, Thessaloniki, Greece Department of Pathology, 424 Military General Hospital, Thessaloniki, Greece Department of Gastroenterology and Hepatology, 424 Military General Hospital, Thessaloniki, Greece Department of Surgery, 424 Military General Hospital, Thessaloniki, Greece Department of Endocrinology, 424 Military General Hospital, Thessaloniki, Greece Arthritis Research Campaign National Primary Care Centre, Keele University, Staffordshire ST5 5BG, UK Service of Anaesthesiology and Palliative Care, University Hospital of Insubria, Viale Borri 57, 21100 Varese, Italy Department of Radiology, University Hospital of Insubria, Viale Borri 57, 21100 Varese, Italy Institute of Pathology, Medical Faculty, University of St Cyrill and Methodius, Street Vodnjanska bb, Skopje, 1000, Republic of Macedonia Research Department of Infection and Population Health, Division of Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK Department of Internal Medicine, Taipei County Hospital, Taipei County, Taiwan (R.O.C.) Department of Family Medicine, Taipei County Hospital, Taipei County, Taiwan (R.O.C.) Institute of Pathology, Medical University Graz, Auenbruggerplatz 25, 8036 Graz Division of Pulmonology, Department of Internal Medicine, Medical University Graz, Auenbruggerplatz 20, 8036 Graz, Austria 4th Orthopaedic Department, General Hospital Asklipieion Voulas, V. Paulou 01 Str, 166-73, Athens, Greece Department of Pharmaceutical Chemistry, University of California, San Francisco, 1700 4th Street, San Francisco, CA 94158, USA Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka, Japan Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, Japan Division of Gastroenterology, Department of Internal Medicine, Aristotle University, Hippokration Hospital, 49 Konstantinoupoleos Str 54642, Thessaloniki, Greece Department of Pathology, Shizuoka City Shizuoka Hospital Department of Surgery, Shizuoka City Shizuoka Hospital, 10-93 Ohtemachi Aoi-ku, Shizuoka 420-8630 First Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Ring Road, N. Efkarpia, 56403, Thessaloniki, Greece Department of Radiology, Faculty of Medicine, Federal University of Rio de Janeiro. Rua Professor Rodolpho Paulo Rocco, 255. Cidade Universitária. CEP 21941-913. Rio de Janeiro, Brazil CDPI- Clínica de Diagnóstico por Imagem, Centro Médico Barrashopping, Avenida das Américas, 4666, grupos 302A, 303, 307, 325, 326. CEP 22631-004. Barra da Tijuca. Rio de Janeiro, Brazil MedImmune Research, Granta Park, Cambridge CB21 6GH, UK Roche Pharma Research and Early Development (pRED), Roche Glycart AG, Schlieren, Switzerland Roche Pharma Research & Early Development ( pRED), Discovery Oncology, Germany Roche Pharma Research & Early Development (pRED), Large Molecule Research, Nonnenwald 2, D-82372 Penzberg, Germany Department of Anatomy, Medical Faculty, Aristotle University of Thessaloniki, Thessaloniki, Greece The Weatherall Institute for Molecular Medicine, University of Oxford, The John Radcliffe Hospital, UK The Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford, OX1 3RE, UK Department of Prosthodontics, Faculty of Dentistry, Suleyman Demirel University, Isparta, 32200, Turkey Orthopaedic Department, Avenue Hospital, Melbourne, Australia Medical School, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece Orthopaedic Department, General Hospital of Veria, Veria, 59100, Greece Alaska Department of Fish and Game, Fairbanks, AK, USA Polar Science Center, APL/University of Washington, Seattle, WA, USA Greenland Institute of Natural Resources, Nuuk, Greenland Department of Social Medicine, University of Sao Paulo, Avenida Bandeirantes, 3900 - Monte Alegre, 14. 048-900 - Ribeirao Preto SP, Brazil Department of Orthopaedics, General Hospital of Kavala, 62, Amerikanikou Eruthrou, Stavrou Street, 65201 Kavala, Greece Department of Pathology, Evgenideio Hospital, 20 Papadiamantopoulou Str, Athens. 11528, Greece Department of Urology, Athens University Medical School, LAIKO Hospital, 17 Agiou Thoma str. , Athens, 11527, Greece Seth G S Medical College and KEM hospital, Parel, Mumbai 400012, India Department of Neurology, Kennemer Gasthuis, Boerhaavelaan 22, 2035 RC, Haarlem, The Netherlands Department of Medical Oncology, National Kyushu Cancer Center, Minami-ku, Fukuoka, Japan Department of Urology, Jichi Medical University Hospital, 3311-1 Yakushiji, Shimotsuke, Tochigi, 3290498, Japan Institute of Microbiology, University Hospital and University of Lausanne, 1011 Lausanne, Switzerland Infectious Diseases Service, Kantonsspital Bruderholz, University of Basel, 4101 Bruderholz, Switzerland Smith Kettlewell Eye Research Institute, 2318 Fillmore St, San Francisco, CA 94115, USA Department of Ophthalmology, California Pacific Medical Center, 2340 Clay St. 5th Floor, San Francisco, CA 94115, USA Department of Hygiene & Epidemiology, University of Ioannina School of Medicine, University Campus, 45110, Ioannina, Greece Department of Pathology San Joaquin General Hospital, 500 West Hospital Road French Camp, CA 95231, USA Department of Internal Medicine San Joaquin General Hospital, 500 West Hospital Road French Camp, CA 95231, USA Department of Surgery San Joaquin General Hospital, 500 West Hospital Road French Camp, California, CA 95231 Department of Radiology, Faculty of Medicine, Fluminense Federal University, Rua Marquês do Paraná, 303. CEP 24. 033. 900. Niterói. Rio de Janeiro, Brazil Service of Diagnostic Radiology, Clementino Fraga Filho Universitary Hospital, Rua Prof. Rodolpho Paulo Rocco, 225. CEP 21. 941. 913. Cidade Universitária. Rio de Janeiro, Brazil St George's Hospital, Tooting, London, UK Queen Elizabeth II Hospital, Welwyn Garden Hospital, 9 Wexner Building, 2 Strype Street, London, N1 3LJ, UK Moorfield Eye Hospital, City road, London EC1V 2PD, UK Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK QTL Genomics Research Center, National Institute of Agrobiological Science, Kannondai 2-1-2, Tsukuba, Ibaraki 305-8602, Japan Centre for Infectious Diseases and Microbiology and the University of Sydney at Westmead Hospital, Darcy Road, Westmead, NSW 2145, Australia Plant Genomic Network Research Team, RIKEN Plant Science Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan Sequence Technology Team, RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan RIKEN BioResource Center, RIKEN Tsukuba Institute, Koyadai 3-1-1, Tsukuba, Ibaraki 305-0074, Japan Faculty of Bio-Science, Nagahama Institute of Bio-Science and Technology, 1266 Tamura, Nagahama, Shiga 526- 0829 Gene Discovery Research Team, RIKEN Plant Science Center, Koyadai 3-1-1, Tsukuba, Ibaraki 305-0074, Japan Crop Research Informatics Laboratory, International Rice Research Institute, PO Box 933, Manila 1099, Philippines Plant Science Center, RIKEN, Yokohama 230-0045, Japan National Institute of Genetics, Mishima 411-8540, Japan Research Institute for Bioresources, Okayama University, Kurashiki 710-0046, Japan School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China Bioengineering Centre of RAS, 60-letiya Oktyabrya prosp. , 7/1, Moscow 117312, Russia Department of Plant Biology, University of Georgia, Athens, GA 30602, USA Plant Breeding Laboratory, Division of Agronomy and Horticulture Science, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502 Division of Reproductive and Developmental Sciences, The University of Edinburgh, Royal Infirmary of Edinburgh, UK Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, People's Republic of China Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India Department of Ophthalmology, University Massachusetts Medical School, Worcester, MA, USA Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA Department of Ophthalmology, University of California San Diego, San Diego, CA, USA Department of Dermatology, Indiana University, USA University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh EH10 5HF Institute of Structural and Molecular Biology, Centre for Translational and Chemical Biology, The University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, UK Medical Genetics Section, University of Edinburgh Centre for Molecular Medicine, Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK Department of Genetics and Genomics, Genzyme Corporation, a Sanofi Company, Framingham, MA 01701 Department of Pharmacology, Genzyme Corporation, a Sanofi Company, Waltham, MA 02451, USA MRC Toxicology Unit and Department of Cancer Studies and Molecular Medicine Hodgkin Building, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK Chemical Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK Section of Experimental Therapeutics, Leeds Institute of Molecular Medicine, St James's University Hospital, UK MRC Cancer Cell Unit, Hutchinson MRC Research Centre, Hills Road, Cambridge CB22 0XZ, UK Department of Cardiology, Toho University Ohmori Hospital, Tokyo, Japan Department of Cardiology, Toho University Sakura Hospital, Sakura, Japan Japan Foundation for Cardiovascular Research, 2-30-17 Narashinodai, Funabashi 274-0063, Japan Department of Pathology, Toho University Sakura Hospital, Sakura, Japan Department of Cardiology, Funabashi-Futawa Hospital, Funabashi, Japan Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka Kazusa DNA Research Institute, 2-6-7 Kazusa-kamatari, Kisarazu, Chiba 292-0818, Japan Department of Zoology, Institute for Emerging Infections, James Martin 21st Century School, University of Oxford, Oxford OX1 3PS, UK Department of Cardiology, Lund University Hospital Department of Cardiology, Aarhus University Hospital, Aalborg Hospital, Aalborg University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Dudley Road, Birmingham B18 7QH, UK AstraZeneca Research and Development, Mo¨ lndal, Sweden Astellas Pharma Inc. , Tokyo, Japan Amgen Inc. , Thousand Oaks, CA, USA Karolinska University Hospital Solna, Stockholm, Sweden Sundsvall Hospital, Sundsvall, Sweden Hospices Civils de Lyon and Université Lyon-1, Lyon MED-EL Headquarters, Innsbruck, Austria Department of Hearing Implant Sciences, Shinshu 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Medicine, Matsumoto, Japan ENT Department, University Hospital of North Staffordshire, Stoke-on-Trent, UK Department of Surgery, Intensive Care Unit, University Hospital of Valladolid, Valladolid, Spain Department of Pharmacology, School of Medicine, University Complutense of Madrid, 28040 Madrid, Spain Department of Physiology, University of Valladolid, Valladolid, Spain Global Clinical Research, Schering-Plough Research Institute, Molenstraat 110, PO Box 20, Oss, The Netherlands Huntington Reproductive Center, Westlake Village, CA Center for Reproductive Medicine, UZ Brussel, Brussels, Belgium Department of Reproductive Medicine and Gynecology, University Medical Center, Utrecht, The Netherlands Research Data and Quantitative Sciences, Schering-Plough Research Institute, Oss, The Netherlands Faculty of Tropical Medicine, Mahidol University, Bangkok Polish Academy of Sciences, Institute of Dendrology, 5 Parkowa Street, Ko´ rnik 62-035, Poland Institute of Plant Genetics, National Research Council, Sesto Fiorentino (Firenze) 50019, Italy Laboratoire 'Caracte´risation Ge´nomique des Plantes', Faculte´ des Sciences, Universite´ Saint-Joseph, Campus Sciences et Technologies, Lebanon De´partement Ecologie et Gestion de la Biodiversite´, CERSP, UMR 7204, Muse´um National d'Histoire Naturelle, 61 rue Buffon, Paris 75005, France Renal Unit, Dumfries and Galloway Royal Infirmary, Dumfries DG1 4AP, UK National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA Department of Cardiology, University Hospital Lausanne—CHUV, Rue du Bugnon 46, CH-1011 Lausanne Royal Veterinary College, London Swiss Tropical Institute, Basel, Switzerland Federal Veterinary Office, Schwarzenburgstrasse 155, CH-3003 Bern, Switzerland USDA, ARS, Pacific Basin Agricultural Research Center, 64 Nowelo Street, Hilo, HI 96720, USA Atlantic Health Promotion Research Centre, Dalhousie University, Halifax, Nova Scotia, Canada B3J 3T1 Departments of Pharmaceutical Sciences and Innovation Studies, Utrecht University, Utrecht, The Netherlands Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, United Kingdom University Hospital of Lausanne, Lausanne, Switzerland NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK Department of Molecular Biology and Biotechnology, University of Kalyani, Kalyani 741235, Nadia, India Present address: Regional Muga Research Station, Central Silk Board, Boko 781 123, Assam, India Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America Max Planck Institute for Biology of Ageing, Gleueler Straße 50a, 50931 Cologne, Germany Department of Zoology, Edward Grey Institute, Oxford University, Oxford OX1 3PS, UK Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK School of Biological Sciences, University of East Anglia, Norwich, 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Department of Surgery, Southampton General Hospital, Tremona Road, Southampton, UK Department of Colorectal Surgery, King's College Hospital, Denmark Hill, London, UK Department of Surgery, Salisbury District Hospital, Salisbury, Wiltshire SB2 8BJ, UK Department of Pediatrics, University of Bern, Inselspital, CH-3010 Bern, Switzerland Institute for Infectious Diseases, University of Bern, CH-3010 Bern, Switzerland Colon Cancer Genetics, Institute of Cell and Molecular Science, Bart's and the London Medical School, Whitechapel, London, UK Experimental Pathology Laboratory, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3PX, UK Department of Histopathology, University of Nottingham, Queen's Medical Centre, Nottingham, UK Division of Cardiology, Department of Medicine, University Health Network, Toronto, Ontario, Canada Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada The Centre for Applied Genomics and Program in Genetics and 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USA SAC, King's Buildings, West Mains Road, Edinburgh EH9 3JG Department of Reproductive Medicine, St Mary's Hospital, Manchester M13 OJH Department of Biology (Area 3) and Hull York Medical School, University of York, Heslington, York YO10 5DD, UK Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 300 George Street, Suite 770J, New Haven, CT 06511, USA Molecular Biometrics LLC, New Haven, CT, USA Molecular Biometrics LLC, Montreal, Quebec, Canada Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK Department of Physiology and Pharmacology, Children's Health Research Institute-Lawson Health Research Institute Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland Department of Biochemistry, University of Cambridge, Cambridge, UK Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK Laboratory of Genes and Development, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK Rigshospitalet, Copenhagen, Denmark Erasmus Medical Centre, Thoraxcenter, Ba583a, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands Kardiologische Gemeinschaftspraxis und Praxisklinik, Munich, Germany Cardialysis BV, Rotterdam Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland Royal Brompton Hospital, London, UK Schweizerisches Herzzentrum—Inselspital, Bern, Switzerland Freie Universita¨ t Berlin, Institute for Biology - Neurobiology, Ko¨nigin-Luise-Strasse 28/30, 14195 Berlin, Germany Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, UK Carson Watts Consulting, King, NC, USA Philip Morris International R&D, Philip Morris Products S. A. , Neuchâtel, Switzerland Department of Urology, Lukas Hospital, Preussenstrasse, Neuss 41464, Germany Department of Urology, HELIOS Hospital, Pieskower Strasse, Bad Saarow 15526 Department of Geosciences and Geography, University of Helsinki, PO Box 64 (Gustaf H a¨llstro¨min katu 2a), 00014 Helsinki Institute of Biotechnology, University of Helsinki, PO Box 56 (Viikinkaari 9), 00014 Helsinki, Finland Department of Geological Sciences, Indiana University, 1001 East 10th Street, Bloomington, IN 47405, USA Oeschger Centre for Climate Change Research, University of Bern, Za¨ hringerstrasse 25, 3012 Bern, Switzerland Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biology, University of Oslo, PO Box 1066, Blindern 0316, Oslo, Norway Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, CA 93106, USA Department of Radiology, The Hillingdon Hospital NHS, Trust, Uxbridge UB8 3NN, UK Department of Colorectal Surgery, The Hillingdon Hospital NHS, Trust, Uxbridge UB8 3NN, UK Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre (GBRC), University of Glasgow, 120 University Place, Glasgow G12 8TA, UK Reproductive and Maternal Medicine, University of Glasgow, 10 Alexandra Parade, Glasgow G31 2ER, UK Centre for Reproductive Biology, The Queen's Medical Research Centre, University of Edinburgh, Edinburgh EH16 4TY, UK The Institute for Computational Engineering and Sciences, the University of Texas at Austin, Austin TX 78712, USA Center for Reproductive Medicine, First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou 510080, People's Republic of China Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine and Infertility, Weill Cornell Medical College of Cornell University, 1305 York Avenue, New York, NY 10021 University of Medicine Gr T Popa Iasi, Iasi, Romania Kuratorium für Heimdialyse, Nuernberg, Germany Hospital Marques de Valdecilla, Universidad de Cantabria, Santander, Spain Fresenius Medical Care, Germany Clin. Nephrol. Hosp. Dr. Carol Davila, Bucharest, Romania Fresenius NephroCare, Krakow, Poland Klinikum Coburg, Coburg, Germany Almada-NMC-Centro Médico Nacional, Lisbon, Portugal Present address: Mothers and Babies Research Centre, Hunter Medical Research Institute, School of Biomedical Sciences, University of Newcastle, Newcastle, NSW 2310, Australia Animal and Agricultural Science, University of Adelaide, Roseworthy, SA 5005, Australia Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, SA 5005, Australia Present address: Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK Kazusa DNA Research Institute, 2-6-7 Kazusa-kamatari, Kisarazu, Chiba 292-0818, Japan Centre for Carbohydrate Recognition and Signalling, Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus C, Denmark 3. Dpto. de Microbiologia, Facultad de Biologia, Universidad de Sevilla, Avda. Reina Mercedes 6, Sevilla, Spain Division of Symbiotic Systems, National Institute for Basic Biology, National Institute for Natural Sciences, Okazaki, Japan NITE Genome Analysis Center, Department of Biotechnology, National Institute of Technology and Evolution (NITE), 2-10-49 Nishihara, Shibuya-ku, Tokyo 151-0066, Japan Laboratory of Microbiology, Faculty of Fisheries, Hokkaido University, 3-1-1 Minato-cho, Hakodate 041-8611, Japan Subsurface Geobiology Advanced Research Team (SUGAR) Team, Extremobiosphere Research Program, Institute of Biogeosciences, JAMSTEC, Yokosuka, Kanagawa 237-0061 Microbial Genome Research Group, Extremobiosphere Research Program, Institute of Biogeosciences, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Yokosuka, Kanagawa 237-0061, Japan Department of Biological Sciences, Chicago State University, Chicago, IL 60628, USA Department of Mathematics, Statistics and Computer Science, University of Illinois at Chicago, Chicago, IL 60607-7045, USA Department of Mathematics, The Chinese University of Hong Kong, Shatin Department of Biotechnology and Bioinformatics, Kuvempu University, Jnanasahyadri, Shimoga 577 451, India Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India Research Unit for Immunoinformatics, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan Laboratory for Immunogenomics, RIKEN Research Center for Allergy and Immunology, Japan Laboratory of Genome Technology, Department of Human Genome Research, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba 292-0818, Japan McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N. Broadway, BRB Room 527, Baltimore, MD 21205, USA National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi 110067, India Department of Biological Sciences, University of Maryland Baltimore County (UMBC), 1000 Hilltop Road, Baltimore, MD 21228, USA Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK Structural Genomics Consortium, University of Toronto, MaRS South Tower, 7th Floor, 101 College St, Toronto, Ontario, Canada M5G 1L7 Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, NIH, USA Institute of Clinical Chemistry, Department of Pathobiochemistry, Otto-von-Guericke University, Magdeburg, Germany Institute of Medical Biochemistry and Molecular Biology, Ernst-Moritz-Arndt University, Greifswald, Germany Division of Cardiology, University Hospital Magdeburg, Otto-von-Guericke University, Leipzigerstr. 44, 39120 Magdeburg, Germany Department of Pharmacology and Toxicology, Dresden University of Technology, Germany Department of Clinical Chemistry and Laboratory Medicine, Dresden University of Technology, Germany Department of Vascular Endothelium and Microcirculation, Dresden University of Technology, Germany Institute of Biometrics, Otto-von-Guericke University, Magdeburg, Germany Carcinogenesis Division, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104- 0045, Japan Department of Bioinformatics and Genomes, Graduate School of Information Science, Nara Institute of Science and Technology, Takayama, Ikoma, Nara 630-0101, Japan Department of Environmental Health Science, University of Georgia, EHS Building, Athens, GA 30602 Georgia Genomics Facility, University of Georgia, 110 Riverbend Road, Athens, GA 30602, USA University of Alaska Museum, 907 Yukon Drive, Fairbanks, AK 99775 Institute of Bioinformatics, Davidson Life Sciences, University of Georgia, Athens, GA 30602, USA Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045 Division of Biological Chemistry and Drug Discovery, The College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK Center for Marine Science, University of North Carolina Wilmington, 5600 Marvin Moss Lane, Wilmington, NC 28409, USA Department of Biological Sciences, University of North Carolina Wilmington, 601 South College Road, Wilmington, NC 28403-3915, USA Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 0SR, UK CNC, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK MRC Epidemiology Unit, Institute of Metabolic Science, UK MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK Institute of Cytology and Genetics, SDRAS, Novosibirsk 630090, Russia Center for Bone Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden Department of Clinical Health Psychology, University of Tilburg, Tilburg, The Netherlands Department of Internal Medicine, Endocrine Section, and EMGO Institute, Free University Medical Center Amsterdam, Amsterdam, The Netherlands PopGen Biobank, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany Institute of Clinical Molecular Biology, Christian-Albrechts University Kiel, Kiel, Germany Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands Tuberculosis Reference Laboratory (TRL), Henan Provincial Centers for Disease Control and Prevention, Zhengzhou, Henan 450016, China Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149 State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100176, China Queensland Mycobacterium Reference Laboratory, Pathology Queensland, Central Laboratory, Royal Brisbane and Women's Hospital, Herston Road, Herston QLD 4029, Australia Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, UK Department of Pharmaceutics and Pharmacy Practice, School of Pharmacy, University of Nairobi, Kenya Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research (Coast), PO Box 230, 80108 Kilifi, Kenya Wellcome Trust Centre for Clinical Tropical Medicine, Faculty of Medicine, Imperial College, Norfolk Place, London W2 1PG, UK Pharmacy Department, Pharmacy and Prescribing Support Unit, Western Infirmary, NHS Greater Glasgow and Clyde, Glasgow G11 6NT, UK The Consortium for National Health Research (CNHR ), PO Box 29832, Nairobi 00202, Kenya Department of Surgical and Perioperative Sciences, Section for Sports Medicine, Umea˚ University, Umea˚ 901 85, Sweden Metabolic Disease Group, The Wellcome Trust Sanger Institute, Cambridge CB10 1SA Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Section for Medicine, Umea˚ University Hospital, Umea˚ 901 87, Sweden Department of Community Medicine and Rehabilitation, Section for Geriatric Medicine, Umea˚ University Hospital, Umea˚ 901 87, Sweden Department of Public Health and Clinical Medicine, Section for Nutritional Research, Umea˚ University, Umea˚ 901 85, Sweden Department of Community Medicine and Rehabilitation, Section for Rehabilitation Medicine, Umea˚ University Hospital, Umea˚ 901 87, Sweden National Heart and Lung Institute, Imperial College, London, UK Clinical Trials and Evaluation Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK Hoˆ pital Lariboisiere, Assistance Publique-Hopitaux de Paris, Universite´ Paris Diderot, INSERM U942, 2 Rue Ambroise Pare´, 75475 Paris Cedex 10, France GVM Hospitals of Care and Research, Cotignola, Italy Faculty of Medicine, University of Sydney, Sydney, Australia Klinik fu¨r Innere Medizin III, Universita¨t des Saarlandes, Homburg/Saar, Germany University Medical Center Groningen, University of Groningen, Groningen, The Netherlands The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA Biomedicum Helsinki, Research Program in Molecular Medicine, University of Helsinki, Finland Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland School of Medicine and Pharmacology, University of Western Australia, Perth 6009, Australia Departments of Medicine and Endocrinology, University of Melbourne, Melbourne 3084, Australia Department of Medicine, Jewish General Hospital, McGill University, Montreal, Canada H3T 1E2 Department of Clinical Science at North Bristol, University of Bristol, Bristol BS10 5NB MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol BS8 2BN, UK Department of Clinical and Biomedical Sciences, The University of Melbourne, Barwon Health, Geelong 3220, Australia Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Oxford OX3 7LD, UK University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Brisbane 4102, Australia Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK Menzies Research Institute, Hobart 7000, Australia Garvan Institute of Medical Research, Sydney 2010, Australia Division of Immune Cell Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK Laboratoire de Pharmacologie de la Synapse, CNRS UMR 8619, Universite´ Paris-Sud, 91405 Orsay Cedex, France Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK Division of Paediatric Surgery, M. G. M Medical College & M. Y. Hospital, Indore - 452001, India Department of Surgery, M. G. M Medical College & M. Y. Hospital, Indore - 452001, India Scientific Institute for Quality of Healthcare (114 IQ healthcare), Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen, The Netherlands Department of Plant Sciences, University of California, One Shields Ave. , Davis, CA 95616, USA Dipartimento di Scienze Agrarie ed Ambientali, Universita` degli Studi di Perugia, Borgo XX giugno 74, 06100 Perugia, Italy Institute for Photonics and Nanotechnology, C. N. R. (Consiglio Nazionale delle Ricerche), Via Valleggio 11, Como 22100, Italy Department of Surgical and Morphologic Sciences, University of Insubria, Viale Borri 57, Varese 21100, Italy C. N. I. S. M. (Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia), University of Insubria, Via Valleggio 11, Como 22100, Italy German Heart Institute Berlin (DHZB), Berlin, Germany Center for Cardiovascular Research (CCR), Charite- Universitaetsmedizin Berlin, Germany Institute of Gender in Medicine (GiM), Charite-Universitaetsmedizin Berlin, Hessische Str. 3-4, 10115 Berlin, Germany Laboratory of Molecular Biology and Stem Cell Engineering, Cardiovascular Department, National Institute of Biostructures and Biosystems, University of Bologna, S. Orsola—Malpighi Hospital (Pavilion 21), via Massarenti 9, Bologna 40138, Italy Equip de Proliferació i Senyalització Cel. lular, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Department of Biology, University of Rochester, Rochester, United States Department of Developmental and Cell Biology, University of California Irvine, Irvine, United States Institució Catalana de Recerca i Estudis Avançats, Barcelona Department of Pathology and Laboratory Medicine, Keck School of Medicine, University of Southern California, Los Angeles, United States Department of Physiology and Biophysics, University of California Irvine, Irvine, United States Cardiology Department, St Antonius Hospital Nieuwegein, PO Box 2500, 3430 EM Nieuwegein, The Netherlands Anesthesiology Department, Hospital General Universitario Gregorio Maran˜o´ n, Madrid, Spain Department of Human Anatomy and Cell Biology, Facultad de Medicina de Badajoz, Badajoz, Spain Cardiology Department, Hospital General Universitario Gregorio Maran˜o´ n, C/ Dr Esquerdo, 46, 28007 Madrid, Spain Pathology Department, Hospital General Universitario Gregorio Maran˜o´ n, Madrid, Spain Center for Population Studies, National Heart, Lung, and Blood Institute, Bethesda, MA, USA Broad Institute of MIT and Harvard, Cambridge, MA, USA Department of Radiology, Tufts-New England Medical Center, USA Medical College of Georgia, Agusta, GA, USA Department of Medicine, Boston University School of Medicine, USA Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas at Houston, Houston, TX, USA Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, MI, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Genetics, Children's Hospital Boston, Boston, MA, USA Department of Medicine, Columbia University, New York, NY, USA Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA Department of Epidemiology and Preventive Medicine, Stritch School of Medicine, Loyola University, Maywood, IL UNC Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, USA Pacific Health Research Institute, Honolulu, HI, USA Division of Cardiology, George Washington University Division of Biology and Medicine, Brown University, USA School of Nursing, University of Mississippi Medical Center, Jackson, MS, USA Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Division of Clinical Epidemiology, Case Western Reserve University, Cleveland, OH, USA Center for Complex Disease Genomics, McKusick- Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S1A8 Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G1L7 Ontario Human Induced Pluripotent Stem Cell Facility, Toronto, Ontario, Canada M5G1L7 Department of Biochemistry and Molecular Biology, Pennsylvania State College of Medicine, Hershey, PA 17033, USA Laboratory of DNA Damage Signaling, Department of Late Effect Studies, Radiation Biology Center, Kyoto University, Yoshida-konoe, Sakyo-ku, Kyoto 606-8501, Japan UMR8200 CNRS, Univ Paris-Sud, Institut Gustave Roussy, 114 rue Edouard Vaillant, Villejuif 94805, France Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford University, Palo Alto, CA 94305 Medical Genetics, Department of Pediatrics, Federico II University, Naples, Italy The Open University, Milton Keynes, UK Telethon Institute of Genetics and Medicine (TIGEM), 80131 Naples, Italy Department of Radiological Services, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA Editor-in-Chief, National Cancer Institute Physician Data Query (PDQ) Screening and Prevention Editorial Board, Bethesda, MD, USA Department of Clinical and Experimental Medicine and Surgery 'F. Magrassi', A. Lanzara', Second University of Naples, Naples, Italy Department of Health Science, Chair of Radiology, University of Molise, Campobasso, Italy Departments of Molecular and Clinical Endocrinology and Oncology, University of Naples 'Federico II', Naples, Italy INSERM UMR-S 631, Marseille, France Innate Pharma, 117 Avenue de Luminy - BP 30191, 13276 Marseille, CEDEX 09, France Assistance Publique - Hôpitaux de Marseille, Hôpital de la Conception, 13385 Marseille, France CNRS, UMR 6102, Marseille, France Department of Radiology, District General Hospital, Southport PR8 6PN, UK Regional Spinal Injuries Centre, District General Hospital, Southport PR8 6PN, UK Department of Urology, District General Hospital, Southport PR8 6PN, UK Copenhagen Wound Healing Center, Bispebjerg Hospital, Bispebjerg bakke 23, 2400 Copenhagen NV, Denmark Novozymes A/S, Krogshoejvej 36, 2880 Bagsvaerd, Denmark Department of Microbiological Surveillance and Research, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, 671 Jaebongro, Dong-gu, Gwangju 501-757, Republic of Korea Centro Malattie Genetiche Cardiovascolari, Area Trapiantologica, IRCCS Fondazione Policlinico San Matteo, Piazzale Golgi 19, 27100 Pavia, Italy CVpath Institute, 19 Firstfield Road, Gaithersburg, MD 20878, USA UMR 698 Inserm, Paris 7-Denis Diderot University, Xavier Bichat Hospital, 46 rue Henri Huchard, 75018 Paris, France Experimental Cardiology Laboratory, UMCU, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands Centre for Environmental Policy, Imperial College London, London, UK Department of Microbiology, University of Stellenbosch, South Africa Institute of the Environment, University of Minnesota, St. Paul, MN, USA School of Biological Sciences, Indian Institute of Technology Delhi, Delhi, India Institute of Bioproduct Development, Universiti Teknologi, Johore Bahru, Malaysia Thayer School of Engineering, Dartmouth College, Hanover, USA Department of Agricultural and Biological Engineering, Pennsylvania State University, University Park, PA, USA Department of Science, Technology and Society, Utrecht University, Utrecht, The Netherlands University of Campinas, Campinas, Brazil Department of Process Engineering, University of Stellenbosch, Stellenbosch, South Africa Department of Biotechnology, Delft University of Technology, Delft, The Netherlands Department of Surgical Sciences, University of Bergen, Bergen, Norway the Swedish Hip Arthroplasty Register, Registercentrum VGR, Sweden Department of Clinical Laboratories, Yokohama City University Hospital, Yokohama Section of Surgical Pathophysiology, the Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark Tissue Typing Laboratory, Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark Department of Surgery, Dalhousie University, Halifax, Canada Orthopaedics Department, Lovisenberg Diaconal Hospital, Oslo Orthopaedics Department, Akershus University Hospital, Loerenskog Orthopaedics Department, Martina Hansens Hospital, Baerum Orthopaedic Centre, Oslo University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Trauma and Reconstructive Surgery, Asklepios Clinic, St. Georg, Hamburg, Germany Centre for Health and Social Economics, Institute of Health and Welfare, Helsinki, Finland Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland Laboratory of Bioinformatics and Systems Biology, Maria Sklodowska- Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5, 02-781 Warsaw Department of Gastroenterology and Hepatology, Medical Center for Postgraduate Education, Warsaw, Poland Department of Gastroenterology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of 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A. , Boulevard du Rectorat, 27b, Sart-Tilman B22, 4000 Lie`ge, Belgium MedImmune Research, Granta Park, Cambridge CB21 6GH, UK Tigran Technologies AB, Medeon Science Park, Malmo¨, Sweden Malmo¨ University Hospital, Malmo¨, Sweden Clinic of Cardiovascular Diseases, Vilnius University, Vilnius Centre of Pulmonology and Allergology, Vilnius University Hospital Santarisˇkiu˛ klinikos, Vilnius, Lithuania Clinic of Chest Diseases, Allergology and Radiology, Vilnius University, Vilnius, Lithuania Vilnius College of Higher Education, Vilnius, Lithuania Department of Mathematical Statistics, Vilnius Gediminas Technical University, Vilnius, Lithuania Laboratory of Clinical Immunology at the Centre of Laboratory Diagnostics, Vilnius University Hospital Santarisˇkiu˛ klinikos, Vilnius, Lithuania PACMeR (Panhellenic Association for Continual Medical Research), Athens, Greece Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden Department of Medical Sciences, Clinical Chemistry, University of Uppsala, Sweden Department of Public Health and Caring Sciences/ Clinical Nutrition and Metabolism, University of Uppsala, Uppsala, Sweden Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden Department of Trauma & Orthopaedics, Barnet Hospital, Hertfordshire, UK Department of Orthopaedic Surgery, Sendai Medical Center, Sendai, Japan Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan Department of Surgical Sciences, University Hospital, Uppsala, Sweden Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Naples, Italy Department of Oncology, Cancer Research UK Cambridge Research Institute, University of Cambridge, LiKaShing Centre, Cambridge, UK Department of Environmental Science, University of Naples 2, Caserta, Italy Division of Clinical and Metabolic Genetics, Hospital for Sick Children Research Institute, Toronto, Ontario Department of Orthopaedic Surgery, Tohoku Rosai Hospital, Sendai Miyagi, Japan Institute for Molecular Science of Medicine, Aichi Medical University, Japan Department of Pathology, Akita University School of Medicine, Akita, Japan Department of Pediatrics, Akita University School of Medicine, Akita, Japan Department of Orthopedic Surgery, Akita University School of Medicine, Japan National Board of Forensic Medicine, Department of Forensic Chemistry, University Hospital, 581 85 Linko¨ping, Sweden Department of Neuroscience, Unit of Pharmacology, Uppsala University, BMC, Box 593, 751 24 Uppsala, Sweden Centre for Clinical Research, Uppsala University, Central Hospital, 721 89 Va¨ stera˚ s, Sweden Department of Oncology, University Hospital, Sweden Department of Medical Sciences, Clinical Chemistry, University Hospital Department of Neuroscience/Speech and Language Pathology, Medical Faculty, Uppsala University, Sweden Institute of Clinical Sciences/Paediatrics, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden Institute of Neuroscience and Physiology/Speech and Language Pathology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden Department of General Surgery, School of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey Department of Physiology, School of Medicine, Ankara University, Ankara, Turkey Department of Pathology, School of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden Department of Orthopaedic Surgery, Shinko Kakogawa Hospital, Japan Department of 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T. 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Mistral, 34112 Frontignan, France Centre de dialyse de Sète, Néphrologie Dialyse St Guilhem, 34204 Sète, France RD - Néphrologie and Groupe Rein et HTA, EA3127, Institut Universitaire de Recherche Clinique IURC-UM1, 104, rue de la Galéra, Ecole Nationale Supérieure de Chimie, 34090 Montpellier, France Service de Néphrologie, Hôpital de La Conception - Université Aix-Marseille, 13005 Marseille, France Epidemiology and Biostatistics Department, EA 2415, IURC - Montpellier University I, Montpellier, France Renal Unit, Lister Hospital DST/NRF Centre of Excellence at the Percy FitzPatrick Institute, University of Cape Town, Rondebosch 7701, South Africa Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK Division of Nephrology, Department of Medicine, University of Wu¨rzburg, Germany Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong Department of Clinical Neurosciences, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London SE5 8AF, UK Centre for Ultrastructural Imaging, King's College London, London SE1 1UL, UK Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo, Chiba, Japan Division of Microbiology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kiyotake, Miyazaki 889-1692, Japan Division of Bioenvironmental Science, Frontier Science Research Center, University of Miyazaki, 5200 Kiyotake, Miyazaki 889-1692, Japan Department of Microbiology, Faculty of Medicine, Kagawa University, 1750-1 Miki-cho, Kita-gun, Kagawa 761-0793, Japan Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan Department of Parasitology and Immunology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770- 8503, Japan Department of Plant Genome Research, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba 292-0818, Japan Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama, Kanagawa 226-0026, Japan Institute of Plant Physiology, Russian Academy of Sciences, Botanicheskaya str. 35, Moscow 127276, Russia Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan Bridgepoint Collaboratory for Research and Innovation, Bridgepoint Health, University of Toronto, Toronto, Ontario, Canada Public Health Services, Capital District Health Authority, Halifax, Nova Scotia, Canada Faculty of Health Professions, School of Nursing, Dalhousie University, Halifax, Nova Scotia Department of Psychiatry, IWK Health Centre, Halifax, Nova Scotia, Canada Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, USA Abteilung Biopsychologie, Fakulta¨ t fu¨ r Psychologie, Ruhr-Universita¨ t Bochum, 44780 Bochum, Germany FB Biowissenschaften, J. W. Goethe-Universita¨ t Frankfurt, Siesmayerstr. 70, 60054 Frankfurt am Main, Germany Gynaecological Oncology, Royal Adelaide Hospital, South Australia, Australia South Australian Research and Development Institute, Turretfield Research Centre, Rosedale, South Australia 5350, Australia Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia Present address: Australian Stem Cell Centre, University of Queensland, Brisbane QLD 4072, Australia Basic Medical Sciences and Clinical Developmental Sciences, St. George's, University of London, UK Brain and Mind Institute, Ecole Polytechnique Fe´de´rale de Lausanne, EPFL, Lausanne, Switzerland Anecova Inc. , Lausanne Centre for Reproductive Medicine, UZ Brussel, Brussels, Belgium Centre for Outcomes Research and Laboratory for Experimental Surgery, UZ Brussel, Brussels, Belgium Institut fu¨r Nutztiergenetik, FLI, Mariensee, Neustadt, Germany Stiftung Tiera¨rztliche Hochschule, Klinik fu¨r Rinder, Reproduktionsmedizinische Einheit der Kliniken, Hannover, Germany Institut National de Recherche Agronomique, INRA University of Geneva, Geneva, Switzerland Instituto Valenciano de Infertilidad (IVI), Valencia, Spain Department of Orthopedics, Kumaran Hospital Pvt Ltd, Poonamalle High Road, Chennai - 600 006, Tamil Nadu, India Rutgers University, 134 Thompson Hall, New Brunswick, NJ 08901, USA Queensland Institute of Medical Research, Brisbane, Queensland 4029 Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA Asthma Research Group, Windsor, ON, Canada University of Windsor University of Western Ontario, London, ON, Canada N6A4V2 Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands Department of Systems Biology, Harvard Medical School, 4 Blackfan Circle, HIM 564, Boston, MA 02115, USA Wellcome Trust Centre for Cell Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh, EH9 3JR, UK International Rice Research Institute, Los Ban˜ os, Philippines Indian Agricultural Research Institute, New Delhi, India Department of Anesthesiology, University of Virginia Health System, PO Box 800710, Charlottesville, VA 22908, USA University of Newcastle, Newcastle Bone and Joint Institute, Royal Newcastle Centre, PO Box 664J, Newcastle, NSW 2300, Australia Adviesbureau E. 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and Policy, University of Delaware, Lewes, DE 19958, USA Akvaplan-niva. , Fram Centre for Climate and the Environment, Norway Institute of Archaeology and Antiquity, University of Birmingham, Birmingham B15 2TT, UK Stroke and Dementia Research Centre, St George's University of London, London SW17 0RE, UK Institute of Life Science and Natural Resources, College of Life Sciences and Biotechnology, Institute of Life Science and Natural Resources, Korea University, Seoul 136-713, Republic of Korea Plant Genomics Laboratory, Department of Applied Plant Sciences, Kangwon National University Laboratory for Biosensing, Qingdao Institute of Bioenergy & Bioprocess Technology, and Key Laboratory of Bioenergy, Chinese Academy of Sciences, 189 Songling Road, Qingdao 266101, People's Republic of China Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea Department of Epidemiology and Public Health, University College London, 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A Centre for Reproductive Medicine, Clinica Valle Giulia Department of Obstetrics and Gynecology, North Shore University Hospital, NYU School of Medicine, Manhasset, NY 11030, USA Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100083, People's Republic of China Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Headington, Oxford OX3 7LD, UK Department of Endocrinology, St Bart's Hospital, University of London, London, UK Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK Howard Hughes Medical Institute, National Center for Behavioral Genomics, and Department of Biology Brandeis University, Waltham, United States Healthcare and Energy Materials Laboratory, Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore Department of Medicine, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK Harvard Medical School, Center for Health and the Global Environment, 401 Park Drive, 2nd Floor East, Boston, MA 02215 Harvard Medical School, Mount Auburn Hospital Walk-In Center, USA Department of Cardiology, University Hospital of Basel, Basel Department of Cardiology, Erasmus MC, Rotterdam, the Netherlands Department of Microbiology and Immunology, The University of British Columbia, 350 Health Sciences Mall, Vancouver, BC, V6T 1Z4, Canada Michael Smith Laboratories, The University of British Columbia, 2185 East Mall, Vancouver, BC, V6T 1Z4, Canada Division of Gastroenterology & Hepatology, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, H0262, MC: 5244, Stanford, CA, 94305, USA Department of Microbiology and Immunology, Stanford University, 299 Campus Drive, Stanford, CA 94305 School of Psychological Sciences, The University of Melbourne, Carlton, VIC 3010, Australia Queensland Brain Institute, The University of Queensland, St Lucia, QLD 4072, Australia UQ Centre for Clinical Research, The University of Queensland, Herston, QLD 4029, Australia Dartmouth College, Department of Psychological & Brain Sciences, 6207 Moore Hall, Room 349, Hanover, NH 03755, USA Duke University, Department of Psychology & Neuroscience, Institute for Genome Sciences & Policy, USA NIDA Clinical Trials Network, Delaware Valley Node, Philadelphia, PA, USA Department of Psychiatry, University of Pennsylvania, 600 Public Ledger Building, 150 South Independence Mall, West, Philadelphia, PA 19106, USA Structure and Motion Laboratory, The Royal Veterinary College, North Mymms, Hatfield, Herts AL9 7TA, UK Division of Cardiology, University of California, San Francisco, CA, USA Cardiology, Department of Experimental and Applied Medicine, University of Brescia, Brescia, Italy Department of Heart Diseases, Medical University, Clinical Military Hospital, Wrocław, Poland Athens University Hospital, Athens, Greece University of California, San Diego Medical Center, San Diego, CA, USA University Medical Center Groningen, Groningen, Netherlands Department of Cardiology, University Hospital Maastricht, Maastricht, The Netherlands Department of Cardiology, Gentofte Hospital, University of Copenhagen, 2009 Hellerup, Denmark Department of Cardiology, J. 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Goethe University, Frankfurt, Germany Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada Department of Medicine, University of Wisconsin, Madison, WI, USA Department of Infectious Disease Epidemiology, Imperial College London, St. Mary's Hospital, Norfolk Place, London W2 1PG, UK Institute of Zoology, Zoological Society of London, Regent's Park, London NW1 4RY, UK Beth-Israel Deaconess Cancer Center and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA Molecular and Cell Biology Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California, USA Department of Orthopaedics, Government Medical College, Srinagar, Jammu and Kashmir, India Universita¨t Flensburg, Institut fu¨r Biologie und ihre Didaktik Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA Centre for the Environment, School of Natural Science, Trinity College, Dublin 2 Aquaculture and Catchment Management Services, Marine Institute, Newport, County Mayo, Ireland Department of Zoology, Ecology and Plant Science, University College Cork, Ireland Department of Applied Sciences, Dundalk Institute of Technology, Dundalk, Ireland School of Marine Science and Engineering, University of Plymouth, Drake Circus, Plymouth PL4 8AA UK Sir Alister Hardy Foundation for Ocean Science, Plymouth, UK MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK Department of Orthopedics, Oskarshamn Hospital, Oskarshamn, Sweden Orthopaedic Research Unit, Prince Charles Hospital, Queensland Institute of Health and Biomedical Innovation, Queensland University of Technology Australian Orthopaedic Association National Joint Replacement Registry, Adelaide, Australia Department of Medical Oncology, St Vincent's University Hospital, Dublin, Ireland Vascular Research Lab, IIS-Fundacion Jimenez Diaz-Autonoma University of Madrid, Spain Inserm Unit 698, Cardiovascular Remodelling, Paris 7, Denis Diderot University, Hoˆ pital X. Bichat, 46 rue Henri Huchard, 75018 Paris, France Hoˆ pital Henri Mondor and U-PEC, France Department of Surgery, Medicine Faculty, Charles University, Pilsen, Czech Republic Karolinska Institute, Stockholm, Sweden St George's Hospital Medical School, London Department of Pathology, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, USA The Randall Division of Cell and Molecular Biophysics and the Cardiovascular Division, King's College London, BHF Centre of Research Excellence, London Institute of Cardiovascular Science, University College London, London, UK Yannis Protonotarios Medical Center, Naxos Island, Greece Unit of Inherited Cardiovascular Diseases, Heart Center of the Young and Athletes, First Department of Cardiology, University of Athens, Athens, Greece Mary Lyon Centre, Medical Research Council, Harwell Science and Innovation Campus, Harwell, Oxfordshire OX11 0RD The University of Edinburgh Centre for Cardiovascular Science, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK Mammalian Genetics Unit, Medical Research Council, Harwell Science and Innovation Campus, Harwell, Oxfordshire OX11 0RD, UK NHS Kidney Care, UK Department of Vascular Surgery, Clinic Schwabing, Munich, Germany Department of Histology and Microscopical Anatomy, University of Munich, Munich, Germany Institute for Prevention of Cardiovascular Diseases, University of Munich, Munich, Germany Department of Biostatistics, University of Iowa, Iowa City, IA, USA INSERM-U999, Universite´ Paris-Sud XI, Hoˆ pital Marie Lannelongue, 133 ave de la Re´sistance, 9230 Le Plessis Robinson, France De´partement de Recherche Me´dicale, Remodelage tissulaire et fonctionnel: signalisation et physiopathologie CNRS-UMR8162, Le Plessis Robinson, France Center for Spatial Information Science and System, George Mason University, 6301 Ivy Lane, Greenbelt, MD 20770, USA Department of Geography, San Diego State University, San Diego, CA 92182-4493, USA Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, A11, Datun Rd, Anwai, Beijing 100101, China College of Applied Sciences and Humanities, Beijing Union University, Beijing 100083, China Division of Molecular and Cellular Biology, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan Department of Neurobiology and Genetics, University of Wu¨ rzburg Department of Ecology and Evolutionary Biology, Yale University, 165 Prospect Street, New Haven, CT 06520, USA Biodiversity, Macroecology and Conservation Biogeography Group, University of Go¨ttingen, Bu¨ sgenweg 2, 37077 Go¨ttingen, Germany Nees Institute for Biodiversity of Plants, University of Bonn, Meckenheimer Allee 170, 53115 Bonn, Germany THRC Tuebingen Hearing Research Center and Department of Otorhinolaryngology, Tuebingen University, Tuebingen, Germany Institute of Electron Microscopy, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany Department of Pediatrics, Clinical Sciences Lund, Lund University, Lund Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK INSERM UMRS 937, Pierre and Marie Curie University (UPMC, Paris 6) and Medical School, Paris F-75634, France Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY Department of Medicine II, Johannes Gutenberg-University Mainz, Langenbeckstr. 1, Mainz 55131, Germany European Academy of Bolzano, Institute for Mummies and the Iceman, Viale Druso 1, 39100 Bolzano, Italy Center for NanoSciences, Ludwig-Maximilians-Universita¨ t Mu¨ nchen, Schellingstraße 4, 80799 Munich, Germany Department of Earth and Environmental Sciences, Ludwig-Maximilians-Universita¨ t Mu¨ nchen, Theresienstraße 41, 80333 Munich, Germany Deutsches Museum, Museumsinsel 1, 80538 Munich Max Planck Institute for Gravitational Physics (Albert Einstein Institute), Am Mühlenberg 1, 14476 Golm School of Mathematical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK Department of Biochemistry, La Trobe University, Plenty Road, Bundoora 3086 Victoria, Australia Hannover Medical School, Institute of Virology, 30625 Hannover, Germany Division of Molecular Biosciences, Department of Life Sciences, Imperial College, London SW7 2AZ, UK German Primate Center, Kellnerweg 4, 37077 Göttingen Department of Chemistry, University of Natural Resources and Life Sciences, A-1190 Vienna, Austria Institut Pasteur, G´en´etique des G´enomes Bact´eriens - 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Petrarca, Naples, Italy G. EN. E. R. A Centre for Reproductive Medicine, Clinica Valle Giulia, Via G. De Notaris 2, 00197 Rome, Italy Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Old Addenbrookes Site, Cambridge CB2 1GA, UK Department of Respiratory Medicine, St James University Hospital, Beckett Street, Leeds, LS9 7TF, UK School of Informatics, University of Edinburgh, Edinburgh ED8 9AB, UK Magdalen College, Oxford OX1 4AU Adelard Institute, Manchester M29 7FZ, UK Faculty of Biotechnology, University of Wrocław, ul. Tamka 2, 50137 Wrocław, Poland Department of Veterans Affairs, Geriatric Research, Education, and Clinical Center, South Texas Health Care System, USA Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, USA Department of Pharmacology and Clinical Neuroscience, Umea˚ University, Umea˚ , Sweden Magdalen College, Oxford OX1 4AU, UK Adelard Institute, Manchester M29 7FZ, UK Department of Pediatrics, San Joa˜ o Hospital, Portugal Laboratoire de Glycobiologie Structurale et Functionelle, USTL, Lille Laboratory for Membrane Trafficking, Center for Human Genetics, University of Leuven and Department for Molecular and Developmental Genetics, VIB, B-3000 Leuven, Belgium Laboratory for Molecular Diagnosis, Center for Human Genetics, University of Leuven, B-3000 Leuven, Belgium Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, The Cell Microscopy Center, Utrecht, The Netherlands Pediatric Endocrinology Division, Children's Hospital, University of Bonn, Bonn German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany Max Planck Institute for Molecular Genetics Center for RNA Biology, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA MRC Centre for Neurodegeneration Research, Department of Neuroscience, King's College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF VIRxSYS Inc. , 200 Perry Parkway, Gaithersburg, MD 20877, USA Genetic Disease Research Branch, National Human Genome Research Institute, National Institute of Health, Bethesda, MD 20892-4472, USA Division of Neurosciences, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5 Center for Human Genome Variation, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708 Division of Neurology, Department of Medicine, Duke University Medical Center Division of Medical Genetics, Institute for Human Genetics, University of California, San Francisco, CA 94143, USA Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE Medical Genetics, Medical University of Vienna, Wa¨ hringer Gu¨ rtel 18 - 20, 1090 Vienna, Austria Center for NanoSciences, Ludwig-Maximilians-Universita¨t Mu¨nchen, Schellingstrasse 4, 80799 Munich, Germany Department of Earth and Environmental Sciences, Ludwig-Maximilians-Universita¨t Mu¨nchen, Theresienstraße 41, 80333 Munich, Germany European Academy of Bolzano, Institute for Mummies and the Iceman, Italy Center of Smart Interfaces, TU Darmstadt, Petersenstrasse 32, 64287 Darmstadt, Germany Structure and Motion Laboratory, The Royal Veterinary College, North Mymms, Hatfield, Herts AL9 7TA, UK Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA Houston IVF, Memorial Hermann Memorial City Hospital, Houston, TX 77024, USA Department of Pathology, Baylor College of Medicine, USA Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA Mechanical Engineering Department, Cornell University, Ithaca, NY 14853, USA Epidemiology and Biostatistics Unit, Catholic University of the Sacred Heart, Rome, Italy Department of Cardiology, Catholic University of the Sacred Heart, Campobasso, Italy Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy Department of Medicine, University of Oulu, Finland Division of Cardiac and Vascular Sciences, St George's, University of London, London, UK Department of Surgery, International Medical Centre, Istiklal Cad. No: 196 33100 Mersin, Turkey Department of Physical Medicine and Rehabilitation, University of Welfare and Rehabilitation, Tehran, Iran Department of Dermatology, Tehran University of Medical Sciences, Imam Khomeini Hospital, Gharib street, Tehran, Iran Department of Physical Medicine and Rehabilitation, Army University of Medical Sciences, 501 Hospital, Etemadzadeh Street, Western Fatemi Street, Tehran, Iran Department of Physical Medicine and Rehabilitation, Semnan University of Medical Sciences, Tehran, Iran Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, UK Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, UK Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA Institute of Human Nutrition and Food Science, Christian-Albrechts University, Düsterbrooker Weg 15-17, 24221 Kiel, Germany The Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA The Department of Genetics, UCL Institute of Ophthalmology, London, UK SUNY Eye Institute, Buffalo, NY, USA Human Oncology and Pathogenesis Program and Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA Clinic for Cardiac Surgery, University of Zurich, Zurich, Switzerland Department of Cardiac Surgery, Leipzig Heart Center, University of Leipzig, Leipzig, Germany Department of Anaesthesiology and Intensive Care Medicine II, Leipzig Heart Center, University of Leipzig, Struempellstrasse 39, 04289 Leipzig, Germany Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, New York, NY 12983, USA Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20852 Rockville, MD, USA Sta¨dtisches Klinikum Karlruhe GmbH, Moltkestrasse 90, 76133 Karlsruhe, Germany Chu de Lille, 2, avenue Oscar Lambret, 59037 Lille, France Berufsgenossenschaftliches Universita¨tsklinikum Bergmannsheil GmbH, Bu¨rkle-de-la-Camp. Platz 1, 44789 Bochum, Germany Cardiovascular Department, Hoˆ pital de la Tour, 1 JD Maillard, 1217 Meyrin, Switzerland Universita¨tsklinikum Freiburg, Abt. Kardiologie und Angiologie, Hugstetter Str. 55, 79106 Freiburg i. Br. , Germany Hoˆ pital prive´ de Parly II le Chesnay, 21 rue Moxouris, 78150 Le Chesnay, France Antonius Ziekenhuis Nieuwegein, Koekoekslaan 1, 3435 CM Nieuwegein, Netherlands St. Agnes-Hospital Bocholt, Germany Maastricht University Medical Centre, 6202 AZ Maastricht, Netherlands Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK Electrophysiology Department, HerzGefa¨ssZentrum Zu¨rich, Klinik Im Park, Seestrasse 220, 8027 Zu¨rich Freeman Hospital, High Heaton, Newcastle upon Tyne NE7 7DN, UK EastbourneHospital, King's Drive, Eastbourne BN21 2UD Rikshospitalet, Oslo Universitetssykehus, Sognsvannsveien 20, Oslo, Norway Hull&East Yorkshire NHS Trust, Castle Hill Hospital, UK Department of Radiology, Women and Child Hospital, Van, Turkey Department of Obstetrics and Gynecology, School of Medicine, Yuzuncu Yil University, Van, Turkey Centre for Immunity, Infection and Evolution, University of Edinburgh, Ashworth Laboratories, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK Boyd Orr Centre for Population and Ecosystem Health, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, South Africa The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK Western Ecological Research Center, US Geological Survey, c/o Marine Science Institute, University of California School of Botany, University of Melbourne, Parkville, Victoria 3010 EcoHealth Alliance, USA Department of Animal Biology and Conservation Science, University of Ghana, Legon, Accra, Ghana Animal Health and Veterinary Laboratories Agency, New Haw, Weybridge, Surrey KT15 3NB STEPS Centre, Institute for Development Studies, University of Sussex, Brighton BN1 9RE, UK Disease Dynamics Unit, University of Cambridge, Madingley Road, Cambridge CB3 OES, UK US Centers for Disease Control and Prevention - Kenya Office, Nairobi, Kenya Division of Evolutionary Biology, Zoological Institute, University of Braunschweig, Braunschweig Department of Biology, Colorado State University, Fort Collins, CO 80523, USA Institute of Zoology, Zoological Society of London, Regent's Park, London NW1 4RY, UK Wildlife Division of the Forestry Commission, Accra, Ghana Centre for African Wetlands, University of Ghana, PO Box LG 67, Legon, Accra, Ghana Drug Applied Research Center, Tabriz University (Medical Sciences), Pashmineh, Daneshgah Street, Tabriz, Iran Department of Radiology, Tabriz University (Medical Sciences), Imam Reza Hospital, Daneshgah Street, Tabriz Department of Physical Medicine and Rehabilitation, Tabriz University (Medical Sciences), Imam Reza Hospital, Daneshgah Street, Tabriz Department of Orthopedics, Tabriz University (Medical Sciences), Shohada Hospital, Gholshahr, Tabriz, Iran Young Researchers Club, Tabriz Islamic Azad University, Tabriz Islamic Azad University Complex, Tabriz, Iran University of Florida College of Medicine-Jacksonville, Jacksonville, FL, USA Department of Cardiovascular Science, University of Sheffield, Sheffield, UK Uppsala Clinical Research Center, Uppsala University, Dag Hammarsko¨ ldsva¨g 14B, Science Park, Uppsala SE-751 85, Sweden Department of Cardiology, A˚ rhus University Hospital, A˚rhus, Denmark Department of Cardiology, Lund University, Lund Department of Cardiology, University Hospital Brno Bohunice, Bohunice, Czech Republic Heart Institute University of Sa˜o Paulo Medical School, Sa˜o Paulo, Brazil Duke Clinical Research Institute, Durham, NC, USA Cardiovascular Center, University Hospital Zurich, Zurich The Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands Erasmus University Rotterdam, Postbus 1738, 3000 DR Rotterdam, The Netherlands Catholic University of Parana, Curitiba, Brazil, 2689 Iguassu Ave, Curitiba 80240 030, Brazil Centre for Applied Conservation Research, Department of Forest Sciences, University of British Columbia, 2424 Main Mall, Vancouver, British Columbia, Canada V6T 1Z4 Department of Biological Science, Florida State University, 319 Stadium Drive, Tallahassee, FL 32306-4295, USA Institute of Biological and Environmental Sciences, School of Biological Sciences, Zoology Building, University of Aberdeen, Tillydrone Avenue, Aberdeen AB24 2TZ, UK Department of Protein Design, Adnexus, A Bristol-Myers Squibb R&D Company, Waltham, MA 02453, USA Peninsula National Institute for Health Research Clinical Research Facility, Peninsula Medical School, Barrack Road, Exeter EX2 5DW, UK Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK Genetics of Complex Traits, Peninsula Medical School, Institute of Biomedical and Clinical Science, Magdalen Road, Exeter EX1 2LU, UK MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK Department of Renal Medicine, King's College London School of Medicine, London, UK Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, NE-50, Cleveland, OH 44195, USA Department of Medical and Molecular Biosciences, University of Technology Sydney, New South Wales 2007, Australia CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA Department of Physiology and Pharmacology, University of Bristol, Bristol, UK Department of Cardiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK Department of Medicine, University College London, London, UK Department of Surgery and Cancer, Imperial College London, London, UK Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Bogor, West Java, Indonesia Reproductive Biology Unit, Junior Research Group of Primate Sexual Selection, German Primate Centre, Go¨ttingen, Germany Department of Psychology, Centre for Comparative and Evolutionary Psychology, University of Portsmouth, Portsmouth, UK De´partement Ecologie, Centre National de la Recherche Scientifique, Physiologie et Ethologie, Strasbourg, France Institute of Biology, Faculty of Bioscience, Pharmacy and Psychology, University of Leipzig, Leipzig, Germany Department of Primatology, Junior Research Group of Primate Kin Selection, Max Planck Institute for Evolutionary Anthropology, Leipzig Courant Research Centre 'Evolution of Social Behaviour', Georg-August-Universita¨ t Go¨ttingen, Go¨ttingen, Germany Entomology, Royal British Columbia Museum, Victoria, British Columbia, Canada V8W 9W2 Department of Forestry Science, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4 Biodiversity Institute of Ontario, University of Guelph, Guelph, Ontario, Canada N1G 2W1 Research Centre, Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada K1A 0C6 Center for Reproductive Medicine, Universitair Ziekenhuis (UZ) Brussel, Brussels, Belgium Fertility Clinic, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark Institut de Ge´ne´tique et de Biologie Mole´culaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, BP 10142, Illkirch Cedex, CU de Strasbourg F-67404, France Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University Hospital Zurich, Switzerland Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria 3168, Australia Department of Human Genetics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong, University of Science and Technology, 1095 JieFang Avenue, Wuhan 430030, People's Republic of China Imperial College Department of Chemical and Systems Biology, Stanford University School of Medicine, CCSR, Rm 3145A, 269 Campus Drive, Stanford, CA 94305-5174, USA National Institute of Aquatic Resources, Technical University of Denmark, Charlottenlund Slot, 2920 Charlottenlund The Niels Bohr Institute, The Niels Bohr International Academy, Blegdamsvej 17, 2100, Copenhagen, Denmark IFISC (UIB-CSIC ), Instituto de Física Interdisciplinar y Sistemas Complejos, Campus Universitat de les Illes Balears, 07122 Palma de Mallorca Birmingham and Midland Eye Centre, Birmingham Department of Public Health, NHS Brent, London HA0 4UZ, UK Department of Primary Care and Public Health, Imperial College London, London W6 8RP, UK NIHR CLAHRC for Northwest London, Imperial College London, London SW10 9NH, UK Applied Research Unit, NHS Brent, London HA0 4UZ, UK Brentfield Medical Practice, London NW10 8TF Department of Anaesthesia, Norfolk and Norwich University Hospital, Norwich NR4 7UY, UK Department of Radiology, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham NG5 1PB, UK University College London Hospitals, London NW1 2BU, UK Department of Trauma and Orthopaedics, Norfolk and Norwich University Hospital, Norwich NR4 7UY, UK The Fowler Kennedy Sport Medicine Clinic, The University of Western Ontario, Ontario Orthopaedic Research Unit, Box 180, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK Department of Orthopaedic Surgery, Amphia Hospital, Breda, the Netherlands Department of Trauma and Orthopaedics, Freeman Hospital, High Heaton, Newcastle upon Tyne, UK Department of Orthopedic Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA. Radiology, University of Munich (LMU), Campus Grosshadern, Munich, Germany Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, The Netherlands Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, SA 5005, Australia Department of Systematic and Evolutionary Botany, University of Vienna, Rennweg 14, A-1030 Vienna, Austria School of Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia, Canada Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, the Netherlands Department of Stomatology, First People's Hospital of Chenzhou, Chenzhou, China. Orthopaedic Biomechanics Laboratory, Excelen Center for Bone and Joint Research and Minneapolis Medical Research Foundation, Minneapolis, MN, USA Institute of Anatomy, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark Orthopaedic Research Laboratory, Department of Orthopedic Surgery, Aarhus University Hospital, Aarhus, Denmark Department of Radiology, Innlandet Hospital Trust, Elverum, Norway. Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA Rudolf Peierls Centre for Theoretical Physics, University of Oxford, 1 Keble Road, Oxford OX1 3NP, UK Astronomy Department, MS 249-17, California Institute of Technology, Pasadena, CA 91125, USA Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021 Resource Ecology Group, Wageningen University, Droevendaalsesteeg 3a, 6708 Wageningen, The Netherlands Department of Chemistry, 6128 Burke Laboratory, Dartmouth College, Hanover, NH 03755, USA Department of Chemical Engineering and Chemical Technology, Imperial College, University of London, London SW7 2BY, UK London Centre for Nanotechnology and Department of Electronic and Electrical Engineering, University College London, Torrington Place, London WC1E 6BT, UK Theory and Modelling, Department of Physics, Chemistry and Biology (IFM ), Linköping University, SE-58183 Linköping, Sweden Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, CCSR Building, Room 3145, Stanford, CA 94305-5174, USA London Centre for Nanotechnology and Department of Electronic and Electrical Engineering, University College London, Torrington Place, London WC1E 6BT, UK Department of Earth Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EQ, UK Department of Orthopedics, Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden Department of Obstetrics and Gynaecology, University of Zimbabwe, Harare, Zimbabwe Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20892, USA Pharmaceutical Institute, University of Kiel, 24116 Kiel, Germany University of Plymouth, Plymouth FRF-FNRS, MARE CENTER, University of Lie`ge, Lie`ge, Belgium Department of Biological Sciences, University of Notre Dame, Indiana, United States of America Division of Life Sciences, Department of Cell Biology and Neuroscience, and Consortium for Risk Evaluation with Stakeholder Participation (CRESP), Nelson Biological Laboratories, Rutgers University, Piscataway, NJ, USA Department of Ecology, Evolution, and Environmental Biology, Columbia University, New York, NY 10027 Department of Environmental and Occupational Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA Sackler Institute for Comparative Genomics, American Museum of Natural History, New York, NY 10024, USA Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USA Section of Neurology, Virginia Mason Medical Center, Seattle, WA 98101, USA Center for Neurogenetics & Neurotherapeutics, University of Washington, Seattle, WA 98195, USA Translational Research Program, Benaroya Research Institute at Virginia Mason Institute of Internal Medicine, Novosibirsk, Russian Federation National Institute of Public Health, Praha, Czech Republic Jagiellonian University, Krakow, Poland Department of Epidemiology and Public Health, University College London Institute of Cardiology, Kaunas, Lithuania Conservation and Genome Resource Bank for Korean Wildlife, Seoul National University, Seoul, South Korea Ocean Committee, Korean Federation for Environmental Movements, Seoul, South Korea Marine Mammal Institute and Department of Fisheries and Wildlife, Oregon State University, Newport, OR 97365 Department of Genetics, University of Cambridge, UK Department of Orthopaedics and Traumatology, Gulhane Military Medical Academy, 06018 Etlik, Ankara, Turkey Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK Department of Epidemiology and Public Health, University College London, London, UK INSERM, U1018, Centre for Research in Epidemiology and Population Health, Hoˆ pital Paul Brousse, Baˆt 15/16, 16 Avenue Paul Vaillant Couturier, F-94807 VILLEJUIF CEDEX, France Centre de Ge´rontologie, Hoˆ pital Ste Pe´rine, AP-HP, France National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU Department of Intensive Care Medicine, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium Department of Animal Studies, U. S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 Department of Obstetrics and Gynaecology, St. George's Hospital, London, UK Shafa Hospital, 15 Khordad Ave, Rasht, Iran 41939 - 55599 MRC Centre for Reproductive Health, The University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ Department of Biological Sciences, Michigan Technological University, Houghton, MI 49931 Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland Clinic for Cardiology, University Hospital Zurich, Switzerland Department of Radiology, University Hospital Zurich, Switzerland Unit´e Mixte de Recherche 619, Biologie du Fruit, Institut National de la Recherche Agronomique (INRA Bordeaux), Universit´es de Bordeaux National Institute of Vegetable and Tea Science (NIVTS), National Agriculture and Food Research Organization, 360 Kusawa, Ano, Tsu, Mie 514-2392, Japan Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba 292-0818, Japan Rheumatology and Hematology, Tohoku University Hospital, 1-1 Seiryo, Aoba-ku, Sendai 980-8574, Japan DNA-Chip Development Center for Infectious Diseases, Research Institute for Microbial Diseases, Suita, Osaka, Japan Department of Molecular Genetics, Research Institute for Microbial Diseases, Suita, Osaka, Japan Center for Advanced Science and Innovation, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan Juntendo Koshigaya Hospital, 560 Fukuroyama, Koshigaya, Saitama 343-0032, Japan NITE Bioresource Information Center, Department of Biotechnology, National Institute of Technology and Evaluation, 2-49-10 Nishihara, Shibuya-ku, Tokyo 151-0066, Japan Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan International Center for Biotechnology, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan Department of Bioactive Molecules, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan Kitasato Institute for Life Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 252-0373, Japan Nagase & Co. Ltd, Research and Development Center, 2-2-3 Murotani, Nishi- ku, Kobe, Hyogo 651-2241 Division of Applied Biological Sciences, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Takeda-4, Kofu, Yamanashi 400-8511, Japan Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan NITE Biological Resource Center (NBRC), Department of Biotechnology, National Institute of Technology and Evaluation, 2-5-8 Kazusakamatari, Kisarazu, Chiba 292-0818, Japan Tohoku Regional Office, National Institute of Technology and Evaluation, 4-5-18 Higashisendai, Miyagino-ku, Sendai, Miyagi 983-0833, Japan Bioresource Laboratories, Mercian Corp. , Japan Biotechnology Research Center, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK Kodak Research Laboratories, Eastman Kodak Company, Rochester, NY 14650, USA Graduate Institute of Medical Sciences, School of Medicine, Taipei Medical University, Taipei 110, Taiwan, Republic of China Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, 2147 Burlington Engineering Labs, Raleigh, NC 27695-7115, USA Cardiovascular Research Center, National Yang-Ming University, Taipei 112, Taiwan, Republic of China Center for Nanoscale Science and Engineering, North Dakota State University, 1805 Research Park Drive, Fargo, ND 58102, USA Energy Science Division, Argonne National Laboratory, Argonne, IL 60439, USA Division of Cardiology, Taipei Veterans General Hospital, Taipei 112, Taiwan, Republic of China Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27606 Department of Pathology, Sisli Etfal Research and Training Hospital, Istanbul, 81080, Turkey Department of General Surgery Sisli Etfal Research and Training Hospital, Istanbul, 81080, Turkey Department of Mechanical and Manufacturing Engineering, Dublin City University, Dublin, Republic of Ireland Trinity Centre for Bioengineering, School of Engineering, Trinity College Dublin, Dublin, Republic of Ireland Department of Anesthesiology and Intensive Care Medicine, Charité University Berlin, Campus Virchow Klinikum, Augustenburgerplatz 1, 13353 Berlin, Germany Centre de Recherches sur la Cognition Animale, CNRS, Universite´ Paul-Sabatier (UMR 5169), Toulouse, France The Danish Hip Arthroplasty Register and Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark Department of Orthopaedic Surgery and Traumatology, Clinical Institute, Odense University Hospital, University of Southern Denmark, Odense, Denmark Department of Clinical Epidemiology, Aarhus University Hospital, Århus Australian Orthopaedic Association National Joint Replacement Registry, Adelaide, Australia Centre for Brain and Cognitive Development, Birkbeck, University of London, London, UK Department of Mechanical Engineering, Imperial College, London Department of Health Science Research, Qatar Science and Technology Park, Qatar Foundation, Doha, Qatar Institute of Medical Statistics and Epidemiology, Munich Technical University, Munich, Germany Karolinska Institutet, Department of Clinical Sciences at Danderyd Hospital, Stockholm, Sweden Swedish Hip Arthroplasty Register, Göteborg, Sweden Department of Anatomy, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic the Lundbeck Centre for Fast-track Hip and Knee Arthroplasty, Copenhagen The Lundbeck Foundation for Fast Track Hip and Knee Surgery, Copenhagen, Denmark Oslo Sports Trauma Research Center, Oslo, Norway Division of Pathology, University of Oslo, and Oslo University Hospital Rikshospitalet, Oslo, Norway Institute of Neuroscience, University of Oregon, 1254 University of Oregon, Eugene, OR 97403, USA Biologic and Materials Sciences, University of Michigan, USA Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan School of Geography, University of Nottingham, Sir Clive Granger Building, Nottingham NG7 2RD, UK Museum of Comparative Zoology and Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA School of Agriculture, Food Science and Veterinary Medicine, University College, Ireland Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) at the Institute for Genetics, University of Cologne, Zülpicher Str 47a, 50674 Cologne, Germany Present address: Department of Mechanical Engineering, Washington State University, Vancouver, WA 98686, USA Department of Mechanical Engineering, Columbia University, 500 W 120th Street, New York, NY 10027 RARAF, Columbia University, 136 S. Broadway, Irvington, NY 10533, USA Department of Animal and Plant Sciences, University of Sheffield, UK Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520-8106, USA Simmons Comprehensive Cancer Center, Department of Biochemistry, and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA Department for Cardiology, University Medical Centre Ljubljana, Zaloška cesta 7, 1000 Ljubljana, Slovenia Poison Control Centre, University Medical Centre Ljubljana, Zaloška cesta 7, 1000 Ljubljana, Slovenia Department of Zoology and Biodiversity Research Center, University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia, Canada V6T 1Z4 Section of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032 Cardiovascular Genetics Division, University of 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Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK Duke University Medical Center, 932 Morreene Road, MS 3333, Durham, NC 27705, USA The Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool, L69 3BX, UK Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT Medecine de la Reproduction, Hoˆ pital Femme Me`re Enfants, Bron, France Clinica las Condes, Santiago Robinson Institute, University of Adelaide, Australia MSD, The Netherlands Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin 2, Ireland Department of Ecology and Evolutionary Biology, Graduate School of Life Sciences, Tohoku University, Aramaki-Aoba 6-3, Aoba-ku, Sendai 980-8578, Japan Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Seiryo-machi 4-1, Aoba-ku, Sendai 980-8575, Japan Faculty of Health Sciences, Jinnah Medical College, Karachi, Pakistan Department of Biological & Biomedical Sciences, Faculty of Health Sciences, The Aga Khan University, Karachi, Pakistan Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Edinburgh EH4 2XU, UK Genomic Medicine Group, Fundacion Publica Galega de Medicina Xenomica, Spanish National Genotyping Center (CeGen)-USC, Centro de Investigacion Biomedica en Red de Enfermedades Raras, Hospital Clinico, Santiago de Compostela, Galicia, Spain Department of Gastroenterology, Hospital Clinic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona, Catalonia Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, East Melbourne, VIC 3002, Australia Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands Familial Cancer Laboratory, Queensland Institute of Medical Research, Herston Q4006, Australia Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Science of Czech Republic, Prague 14220, Czech Republic Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria, Australia Section of Cancer Genetics, Institute of Cancer Research, Sutton SM2 5NG, UK Division of Genetics and Molecular Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA Department of Clinical Pharmacology, Oxford University, Old Road Campus Research Building, Oxford OX3 7DQ, UK Cancer Research UK Laboratories, Strangeways Research Laboratory, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland Bioinformatics, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK Department of Family Medicine-Research Division, Case Western Reserve University, 11001 Cedar Avenue, Cleveland, OH 44106-7136, USA Institute of Medical Genetics, School of Medicine, Cardiff University, UK Division of Imaging Sciences, King's College London BHF Centre, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK Division of Cardiology, King's College London BHF Centre, The Rayne Institute, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK Montreal Heart Institute, Montreal, Quebec, Canada Ospedale Regionale di Treviso, Piazzale Ospedale, Treviso, Italy Southlake Heart Rhythm Program, Southlake Regional Health Centre, 105-712 Davis Drive, Newmarket, Ontario, Canada L3Y 8C3 Royal Jubilee Hospital, Victoria, British Columbia, Canada Hamilton Health Sciences Centre, Hamilton, Ontario, Canada Haukeland University Hospital, Bergen, Norway Casa di Cura Santa Maria, Bari, Italy Hospital General Universitario Gregorio Maran˜o´ n, Madrid, Spain San Raffaele Hospital, Milan, Italy Cardiology Department, Ferrarotto Hospital, University of Catania, Via Citelli 6, 95124 Catania, Italy Centre Hospitalier de Compie`gne, Compie`gne Institut de Cardiologie et de Pneumologie de Que´bec/Que´bec Heart and Lung Institute, Laval University, 2725 Chemin Sainte-Foy, Que´bec, QC, Canada G1V-4G5 Centre Hospitalier Re´gional et Universitaire de Lille, EA2693, Lille F-59019, France Cliniques Universitaires St Luc de Bruxelles, Brussels, Belgium Department of Ophthalmology, St James' s University Hospital, Leeds LS9 7TF, UK Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK Gene Tech Lab, 146/1, Shadman Jail Road, Lahore, Pakistan Department of Ophthalmology, St Thomas' Hospital, London, UK Anatomy and Embryology Department, Al- Azhar University, Cairo, Egypt Department of Ophthalmology, Marmara University Medical School, Istanbul, Turkey Department of Obstetrics and Gynaecology, King Edward Medical University, Lahore Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, 10 Center Drive - Room 12N226, Bethesda, MD 20892-1906, USA Department of Clinical Physiology/CVM, Faculty of Health Science, Linko¨ ping University, Sweden Department of Internal Medicine, Sunderby Hospital, Lulea˚, Sweden Division of Paediatrics, Department of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Queen Silvia Children´s Hospital, SE-416 85 Gothenburg, Sweden Department of Cardiology, University Hospital, Lund University, Sweden OPTIMA, Department of Physiology, Anatomy and Genetics, University of Oxford, UK Department of Pathology, University Hospital Eppendorf, Hamburg, Germany Department of Radiology, University Hospital Eppendorf, Hamburg, Germany Department of Cardiology/Electrophysiology, University Hospital Eppendorf, University Heart Center, Martinistr. 52, D-20246 Hamburg, Germany Lipid Research Clinic, The University of Iowa, Iowa City, IA, USA Inserm UMRS 587, Paris, France De´ partement de Neuroscience, Unite´ de Ge´ ne´ tique et Physiologie de l'Audition, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris cedex 15, France Colle` ge de France, 75005 Paris, France Institut Curie CNRS, France CNRS URA 2185, Paris, France Plate-Forme de Biophysique des Macromole´ cules et de leurs Interactions, Institut Pasteur, 75015 Paris, France Plant Gene Expression Center, US Department of Agriculture/Agricultural Research Service, Albany, CA 94710, USA Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina Instituto de Ingeniería Genética y Biología Molecular (INGEBI-CONICET), Vuelta de Obligado 2490, Piso 2, C1428ADN, Buenos Aires, Argentina Department of Plant and Microbial Biology, University of California at Berkeley, 800 Buchanan Street, Albany, CA 94710, USA Neurobiology-Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD 20892 Institute of Biotechnology, University of Helsinki, Helsinki, Finland Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA Department of Orthopedic Surgery, Fukushima Rosai Hospital, 3-Numajiri, Tsuzura-machi, Uchigo, Iwaki 973-8403, Japan Calpain Project, Department of Advanced Science for Biomolecules, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan Laboratory of Comparative Genomics, Graduate School of Information Science, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara 630-0192, Japan Kitasato Institute for Life Science, Kitasato University, 5-9-1 Shirogane, Minato-ku Tokyo 108-8641, Japan Division of Microbiology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kiyotake, Miyazaki 899-1692, Japan Frontier Science Research Center, University of Miyazaki, 5200 Kiyotake, Miyazaki 899-1692, Japan National Institute for Basic Biology, National Institutes of Natural Sciences, Nishigonaka 38, Myodaiji, Okazaki 444-8585 Department of Bacteriology, National Institute for Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Niigata 956-8603, Japan Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kasiwanoha, Kashiwa, Chiba, 277-8561, Japan Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai, Miyagi 981-8555, Japan National Research Institute of Brewing, 3-7-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-0046, Japan Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1, Higashi, Tsukuba, Ibaraki 305-8566, Japan Department of Pediatrics, Emory University School of Medicine, 105-R Whitehead Medical Research Building, Atlanta, GA 30322, USA Department of Pathology, Epithelial Pathobiology Unit, Emory University School of Medicine, 105-F Whitehead Medical Research Building, Atlanta, GA 30322, USA Division of Bioenvironmental Science, Frontier Science Research Center, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889-1692, Japan Kitasato Institute for Life Sciences, Kitasato University, Kitasato 1-15-1, Sagamihara, Kanagawa 228-8555, Japan Graduate School of Systems Life Sciences, Kyushu University, Hakozaki 6-10-1, Higashi-ku, Fukuoka 812-8581 Division of Microbiology and Oral Infection, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-7-1, Nagasaki 852-8588, Japan Department of Computational Biology, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwanoha 5-1-5, Chiba 277-8561, Japan Graduate School of Genetic Resources Technology, Kyushu University, Hakozaki 6-10-1, Higashi-ku, Fukuoka 812-8581, Japan Department of Microbiology, School of Dentistry, Aichi-Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan School of Life Sciences, Fudan University, Shanghai, PR China National Center for Gene Research and Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 500 Caobao Road, Shanghai 200233, PR China College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, PR China Department of Botany, National Museum of Nature and Science, Japan Department of Biology, Keio University, 4-1-1 Hiyoshi, Kohoku, Yokohama 223-8521, Japan Center for Gene Research, Nagoya University, Chikusa, Nagoya 464-8602, Japan Graduate School of Humanities and Sciences, Ochanomizu University, 2-1-1 Otsuka, Bunkyo, Tokyo 112-8610, Japan Kazusa DNA Research Institute, 2-6-7 Kazusa-kamatari, Kisarazu, Chiba 292-0818, Japan National Institute of Agrobiological Sciences, Kannon-dai 2-1-2, Tsukuba, Ibaraki 305-8602, Japan Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK Department of Biological Sciences, Graduate Schools of Science and Engineering, Tokyo Metropolitan University, Minamiohsawa, Hachioji, Tokyo 192-0397, Japan Graduate School of Life Sciences, Tohoku University, Katahira, Aoba-ku, Sendai 980-8577, Japan Kazusa DNA Research Institute, 2-6-7 Kazusa-kamatari, Kisarazu, Chiba 292-0818, Japan Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium Department of Mathematics, University of Michigan, Ann Arbor, MI 48109, USA Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA Frontier Laboratories of Value Creation, Sapporo Breweries Ltd, Yaizu, Shizuoka 425-0013, Japan Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center, Japan Research Laboratories of Brewing Technology, Asahi Breweries, Ltd, Moriya, Ibaraki 302-0106, Japan Department of Fermentation, Faculty of Applied Bio-Science, Tokyo University of Agriculture, Setagaya-ku, Tokyo 156-8502, Japan Research Institute, Gekkeikan Sake Co. , Ltd, Kyoto 612-8385 General Research Laboratory, Kiku-Masamune Sake Brewing Co. , Ltd, Kobe, Hyogo 658-0026, Japan R&D Planning Division, Products Development Center, Suntory Holdings Ltd, Kawasaki, Kanagawa 211-0067, Japan Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581 Gunma Industrial Technology Center, Maebashi, Gunma 379-2147, Japan Food Technology Research Center, Hiroshima Prefectural Technology Research Institute, Hiroshima 732-0816, Japan School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo 650-8530, Japan National Research Institute of Brewing, Higashi-hiroshima, Hiroshima 739-0046, Japan General Research Laboratory, Ozeki Corporation, Nishinomiya, Hyogo 663-8227, Japan Research and Development Department, Hakutsuru Sake Brewing Co. , Ltd, Kobe, Hyogo 658-0041, Japan Brewing Society of Japan, Kita-ku, Tokyo 114-0023, Japan Kagoshima Prefectural Institute of Industrial Technology, Kagoshima 899-5105, Japan Department of Applied Molecular Bioscience, Yamaguchi University Graduate School of Medicine Central Laboratories for Frontier Technology, Kirin Holdings Co. , Ltd, Yokohama, Kanagawa 236-0004, Japan National Institute of Technology and Evaluation, Shibuya-ku, Tokyo 151-0066, Japan Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa 226-8501, Japan Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan Nihonsakari Co. , Ltd, Nishinomiya, Hyogo 662-8521, Japan Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan Food Research Center, Aichi Industrial Technology Institute, Nagoya, Aichi 451-0083, Japan Department of Biotechnology, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan National Institute of Plant Genome Research (NIPGR), Aruna Asaf Ali Marg, New Delhi 110 067, India Plant Genomic and Breeding Research Institute, Seoul National University, Seoul 151-921, Republic of Korea Rural Development Administration, Gyeonggi 441-770, Republic of Korea Department of Plant Science and Research Institute for Agriculture and Life Sciences, Seoul National University, San 56-1, Sillim-dong, Gwanak-gu, Seoul 151-921, Republic of Korea Departamento de Biología Celular, Facultad de Biología, Universidad de Sevilla, Avda Reina Mercedes s/n, 41012 -Sevilla, Spain Instituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla and CSIC, Avda Américo Vespucio, 49, 41092-Sevilla, Spain Institute of Food Biotechnology and Genomics, National Academy of Science of Ukraine, Ukraine Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Corrensstrasse 3, D-06466 Gatersleben, Germany Molecular Population Genetics Group, Temasek Life Sciences Laboratory, National University of Singapore, 1 Research Link, Singapore 117604, Republic of Singapore Molecular Plant Physiology, Institute of Environmental Biology, Utrecht University, Padualaan 8, 3584CH Utrecht, The Netherlands Institute of Biological Sciences, University of Wales, Aberystwyth, Edward Llwyd Building, Ceredigion SY23 3DA, UK Department of Geriatrics, the First Affiliated Hospital, Third Military Medical University, Chongqing, China Department of Microbiology and Molecular Genetics, Michigan State University, USA Department of Molecular Biology, Umeå University, Umeå, S-901 87, Sweden Doseepnazratm, Ietanltyof Botany, University of Jammu, Jammu 180003, India Signaling Pathway Research Unit, RIKEN Plant Science Center, Yokohama, Kanagawa, Japan Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143001, India Department of Molecular Medicine and Pathology, University of Auckland, 85 Park Rd, Auckland, 1142, New Zealand Infectious Diseases & Immunity, Department of Medicine, Imperial College London, Hammersmith Campus, London, W12 0NN Microbiology, Department of Medicine, Imperial College London, South Kensington Campus, London, SW7 2AZ Department of Biology, National University of Ireland Maynooth, Maynooth, Ireland Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland School of Natural Sciences, Trinity College Dublin, Dublin 2, Ireland Teagasc Crops Research Centre, Ireland University of Rochester, Rochester, NY, USA Spreewaldklinik, Burg, Germany Klinik am See, Rehabilitation Center for Cardiovascular Diseases, Germany Department of Medical Biometry and Epidemiology, University Medical Centre, Hamburg, Germany CRV Clinical Department, Boston Scientific, Diegem Klinik Augustinum, Munich, Germany Department of Family Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan Department of Oncology/ Hematology, National Cancer Center Hospital East, Kashiwa, Japan Department of Biomechanical Engineering, Faculty of Mechanical, Maritime, and Materials Engineering, Delft University of Technology, Delft, the Netherlands Howard Hughes Medical Institute, Baltimore, Maryland, USA Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA School of Public Health, Johns Hopkins University, Baltimore, Maryland Cardiovascular Institute, University of Colorado, Denver, CO, USA Department of Emergency and Cardiovascular Medicine, Institute of Medicine, Sahlgrenska Academy, Go¨ teborg University, Go¨ teborg, Sweden III Division of Cardiology, Medical University of Silesia, Katowice, Poland Instituto FLENI, Buenos Aires National Heart and Lung Institute, Imperial College London, London, UK Cardiovascular Research Program, University of Toronto, Ontario, Canada Myasnikov Institute of Cardiology, Moscow, Russia Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA Cardiology, Department of Experimental and Applied Medicine, University of Brescia, Italy Department of Cardiology, La Pitie´-Salpe´trie`re Hospital, Paris, France Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA Departamento de Enfermedades Cardiovasculares, Hospital Clinico Pontificia Universidad Cat o´lica de Chile, Santiago de Chile, Chile Klinik fu¨r Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universita¨tsklinikum des Saarlandes, Homburg, Germany Myogen/Gilead Inc. , Westminster, CO, USA Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA San Francisco Medical Center, University of California, San Francisco, California Flinders University Department of Nutrition and Dietetics, Adelaide SA 5001, Australia Department of Rehabilitation and Aged Care, Repatriation General Hospital, Daw Park SA 5041 Flinders University Department of Rehabilitation and Aged Care, Adelaide SA 5001, Australia Department of Microbiology and Immunology, Virginia Commonwealth University, Box 980678, Richmond, VA 23298, USA Molecular therapeutics section, Medical Oncology Branch, National Cancer Institute, Building 10 - Room 13N248, National Institutes of Health, USA School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, UK Conservation and Research Center, Taipei Zoo, Taipei 11656, Taiwan, Republic of China School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK Department of Biochemistry, Molecular Biology & Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA MRC Centre for Outbreak Analysis and Modelling, Imperial College London, Department of Infectious Disease Epidemiology, St Mary's Campus, London W2 1PG, UK Department of Plant Biology, University of California, Davis, 1 Shields Avenue, Davis, CA 95616, USA Department of Urology, Sapporo Medical University, Sapporo, Japan Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan Section of Bacterial Pathogenesis, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Japan Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Komaba 3-8-1, Meguro-ku, Tokyo 153-8902, Japan Department of Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan Genome Research Center, NODAI Research Institute, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan Center for Biological Resources and Informatics, Tokyo Institute of Technology, 4250-B65, Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan Department of Biological Information, Tokyo Institute of Technology, 4250-B65, Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan Department of Medical Oncology, Prince of Wales Hospital, Randwick, NSW 2031, Australia Prince of Wales Clinical School, University of NSW, Kensington, NSW 2052, Australia School of Women's and Infants' Health, University of Western Australia, King Edward Memorial Hospital, 374 Bagot Road, Subiaco, WA 6008, Australia School of Surgery, University of Western Australia, Crawley 6009, Australia Department of Gynecology and Obstetrics, The Sixth Affiliated Hospital of SUN YAT-SEN University, Guangzhou, PR China Family 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Britain Institute fu¨r Clinical and Experimental Medicine (IKEM), Prague, Czech Republic CHU de Nancy, Nancy, France UZ Leuven, Leuven Odense University Hospital, Odense, Denmark Hospital Clinic Barcelona, Barcelona, Spain National Institute of Cardiology, Warsaw, Poland Cardiocenter, 3rd Faculty of Medicine, Charles University Prague, Czech Republic Institute for Molecular Bioscience and Division of Molecular Cell Biology, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78227, USA Department of Public Health and General Practice, NTNU, Trondheim 7006, Norway Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim 7006, Norway Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, NTNU, Trondheim 7006, Norway Molecular Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India Complementary Medicine, Peninsula Medical School, University of Exeter, Exeter, UK Brain Disease Research Centre, Korea Institute of Oriental Medicine, Korea Institute for Experimental and Clinical Pharmacology and Toxicology, University Hospital Eppendorf, Hamburg, Germany Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany Cardiovascular Research Center and Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg 20246, Germany Department of Medical Biometry and Epidemiology, University Hospital Eppendorf, Hamburg, Germany Department of Physiology, University of Veterinary Medicine Hannover, Hannover, Germany Institute for Lasertechnology, Ulm, Germany Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic Institute of Cellular and Integrative Physiology, University Hospital Eppendorf, Hamburg, Germany Institute for Forensic Medicine, University Hospital Eppendorf, Hamburg Division of Immune Cell Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK SA Pathology, Women's and Children's Hospital, North Adelaide, South Australia 5006, Australia Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK Cambridge Institute of Medical Research, University of Cambridge, Cambridge CB2 2XY, UK Department of Paediatrics, The University of Adelaide, Adelaide, SA 5000 Laboratory for Tissue Engineering, Charite´, University Medicine Berlin, Campus Mitte, Berlin, Germany Department of Cardiology and Pneumology, University Medicine Berlin, Germany Berlin - Brandenburg Center for Regenerative Therapies, University Medicine Berlin, Germany Sanofi Aventis, R&D, Frankfurt, Germany Department of Cardiology, University Hospital Maastricht, Maastricht, The Netherlands Division of Clinical 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W. Goethe University, Theodor-Stern-Kai 7, D 60590 Frankfurt, Germany Population Health Research Institute, McMaster University, Hamilton, Canada Gentofte Hospital, University of Copenhagen, Hellerup, Denmark University of Washington, Seattle, WA, USA Graduate School of Horticulture, Chiba University, Matsudo, Chiba 271-8510, Japan University Hospital Essen, Essen, Germany Elisabethinen University Teaching Hospital, Linz, Austria University of Pittsburgh, Scaife Hall 564, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA Department of Dermatology, Medical University of Graz, Graz, Auenbruggerplatz 8, A-8036 Graz, Austria Department of Dermatology, University of L'Aquila, L'Aquila, Italy University of Nebraska Medical Center, 988106 Nebraska Medical Center, Omaha, NE 68198-8106, USA Department of Cardiology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria Department of Cardiology, University of Goettingen, Goettingen, Germany Department of Cardiology, Papworth Hospital, Cambridge CB23 3RE, UK Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY Medical Department, Novartis Pharmaceuticals UK Ltd, Frimley Business Park, Camberley, Surrey GU16 7SR, UK Novartis Pharma AG, Fabrikstrasse 4, CH-4056 Basel, Switzerland Microvascular Research Laboratories, Department of Physiology and Pharmacology, School of Veterinary Sciences, Bristol Heart Institute, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada Developmental and Stem Cell Biology Program and Ontario Human Induced Pluripotent Stem Cell Facility, The Hospital for Sick Children, 101 College Street, Toronto, ON, M5G 1L7, Canada Department of Dermatology, Yale Medical School, New Haven, CT 06520, USA Department of Anesthesiology, Saint-Luc Hospital Medical School, Université Catholique de Louvain, Avenue Hippocrate 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Department of Plant Molecular Biology, University of Lausanne, Biophore Building, DBMV, CH-1015 Lausanne, Switzerland Department of Medicine, McMaster University, 1200 Main Street West Hamilton, ON, L8N 3Z5, Canada Faculty of Medical and Human Sciences, School of Pharmacy, University of Manchester Advanced Science and Technology Research Group, Mitsubishi Research Institute, Inc. , 2-3-6 Otemachi, Chiyoda-ku, Tokyo 100-8141, Japan Gene Discovery Research Team, RIKEN Plant Science Center, Koyadai 3-1-1, Tsukuba, Ibaraki 305-0074, Japan Division of BioResource, Frontier Science Research Center, University of Miyazaki, Miyazaki 889-2192, Japan Laboratory of Plant Molecular Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan Experimental Farm, Kyoto University, Takatsuki, Osaka 569-0096, Japan Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido 060-8589, Japan Sequence Technology Team, RIKEN 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I. T. Scheme VII M, Kolkata 700 054, India Institute for Advanced Biosciences, Keio University, Japan Department of Computational Biology, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8561, Japan Department of Bioinformatics and Genomes, Graduate School of Information Science, Nara Institute of Science and Technology, Japan Departments of Medicine and Surgery, Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, E/CLS 608, Boston, MA 02215, USA Department of Medical Biophysics, University of Toronto, 27 King's College Circle, Toronto, ON, M5S 1A1, Canada Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada Department of Anaesthesia, Royal Cornwall Hospital Trust, Royal Cornwall Hospital, Truro, Cornwall TR1 3LJ, UK Kenya Medical Research Institute/Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Kilifi, Kenya LKS Faculty of Medicine, Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China Rheumatology Unit, Department of Medicine at the Karolinska, University Hospital Solna, SE-17176 Stockholm, Sweden Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK Liverpool School of Tropical Medicine, Liverpool, UK INDEPTH Network, Accra, Ghana Department of Paediatrics, University of Oxford, Oxford OX3 9DU, UK Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7LJ, UK Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam School of Infection and Immunity, College of Medical and Dental Sciences, University of Birmingham, UK School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK Division of Orthopaedic Surgery, McMaster University, Hamilton, Ontario, Canada Department of Epidemiology and Public Health, UCL, London Division of Community Health Sciences, St George's, University of London, UK Department of Primary Care and Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK Centre de Ge´rontologie, Hoˆ pital Ste Pe´rine, AP-HP, Paris, France INSERM U1018, Centre for Research in Epidemiology and Population Health, Hoˆ pital Paul Brousse, Villejuif Cedex, France Embrapa Pecuaria Sul, Brazil Research School of Biology, The Australian National University, Canberra ACT 0200, Australia School of Public Health, Imperial College UK Department of Microbiology and Infection Control, University Hospital of North Norway, Norway Department of Medical Biology, Faculty of Medicine, University of Tromsø Department of Pharmacy, Faculty of Medicine, University of Tromsø, 9037 Tromsø, Norway Genøk-Center for Biosafety, Research Park, 9294 Tromsø Norwegian Institute of Public Health, Nydalen, 0403 Oslo, Norway Department of Opthalmology, Hereford County Hospital, Hereford HR1 2ER, UK Department of Cardiology, Hereford County Hospital, Hereford HR1 2ER, UK HIV Care and Treatment Centre, Haydom Lutheran Hospital, Mbulu, Tanzania Faculty of Medicine, University of Oslo, Oslo, Norway Department of Infectious Diseases, Oslo University Hospital, Ulleval, Oslo, Norway Department of Microbiology, Oslo University Hospital, Ulleval, Oslo, Norway Centre for Development Studies, University of Agder, Kristiansand, Norway Research Unit, Sorlandet Hospital HF, Kristiansand Medical Department, University Hospital of North Norway, Tromso, Norway Institute of Clinical Medicine, University of Tromso, Tromso, Norway School of Biological and Chemical Sciences, Queen Mary, University of London, United Kingdom Instituto de Biología, Universidad de Antioquia, Medellín, Colombia Centre d'Investigation Clinique de Nancy CIC-P 9501, INSERM, CHU de Nancy, Nancy-University, F-54201 Dommartin-le`s-Toul, France INSERM U698, Cardiovascular Haematology, Bio-Engineering and Remodelings, Paris 7 Denis Diderot University, Bichat- Claude Bernard Hospital, 46 rue Henri Huchard, F-75877 Paris Cedex 18, France Yale University School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, 300 George Street, Suite 770J, New Haven, CT 06511, USA Kardiologische Praxis, Dessau, Germany Department of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, Saarland University Hospital, Kirrberger Strasse 1, 66424 Homburg/Saar, Germany Department of Cardiology, Angiology and Pneumology, Klinikum Coburg GmbH, II, Medizinische Klinik, Coburg, Germany Department of Internal Medicine—Herz-Kreislauf-Zentrum, Segeberger Kliniken GmbH, Bad Segeberg, Germany Klinikum Dortmund gGmbH, Medizinische Klinik Mitte—Cardiology, Dortmund, Germany Herzzentrum Brandenburg, Bernau, Germany Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany Department of Internal Medicine—Cardiology and Angiology, Evangelisches Krankenhaus Bielefeld, Bielefeld, Germany Klinikum Universita¨t Mu¨nchen—Großhadern, Med. Klinik & Poliklinik I, Mu¨nchen NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital Clinica delle Malattie Infetive e Tropicali, Modena, Italy Division of Infectious Diseases, Jewish General Hospital, McGill University, Montreal, Quebec, Canada Department I of Internal Medicine, Clinical Trials Centre Cologne, ZKS Köln, BMBF 01KN1106, Center for Integrated Oncology CIO Köln Bonn, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Germany Department of Infectious Diseases and Microbiology, Maisonneuve-Rosemont Hospital, Faculty of Medicine, University of Montreal, Quebec, Canada Department of Microbiology-Immunology and Infectious Diseases, University of Calgary, Canada Cardiology Department, Arrhythmia Section, Hospital Clinic, Thorax Institute, University of Barcelona, Villarroel, 170, Barcelona, 08036 Catalonia, Spain Department of Internal Medicine, University of Florence and Regional Centre for Hereditary Endocrine Tumors, Unit of Metabolic Bone Diseases, University Hospital of Careggi, Viale G Pieraccini 6, 50139 Florence, Italy Departments of Mechanical and Aerospace Engineering and Orthopaedics, Case Western Reserve University, Cleveland, OH, USA University Hospital of Schleswig-Holstein, Campus Luebeck, Department of Surgery, Ratzeburger Allee 160, D-23538 Luebeck, Germany Section of Orthopaedic Surgery, Department of Surgical Sciences Department of Orthopaedic Surgery, Norwegian Arthroplasty Register, Haukeland University Hospital, Bergen Department of Orthopaedic Surgery, Lovisenberg Deaconal Hospital, Oslo Orthopaedic Department, Oslo University Hospital, University of Oslo, Oslo, Norway Department of Orthopaedic Surgery, Akershus University Hospital, Lørenskog The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen Department of Surgical Sciences, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway Department of Clinical Sciences and Orthopedics, Lund University, Department of Orthopedics, Skåne University Hospital, Malmö, Sweden Department of Orthopedics, Falun Central Hospital and Center for Clinical Research Dalarna, Falun Center for Rheumatic Diseases, Yokohama City University Medical Center, Japan Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, the Netherlands Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia Department of Orthopaedics, Rijnstate Hospital, Arnhem, the Netherlands 1146 N Pavilion Department of Immunology, Duke University, Durham, NC 27710, USA 1146 N Pavilion Department of Medicine, Division of Cellular Therapy, Duke University Medical Center, Durham, NC 27710 Department of Bioinformatics, Erasmus MC, University Medical Center Rotterdam, the Netherlands Department of Orthopaedics, Harold K Dunn Orthopaedic Research Laboratory, University of Utah, Salt Lake City, UT, USA Department of Orthopaedics, Skåne University Hospital, Malmö Department of Radiology, University Medical Center, Johannes Gutenberg University Mainz, Germany Department of Orthopaedics, Tergooiziekenhuizen, Hilversum, the Netherlands Department of Research, Development and Education, Sint Maartenskliniek, Nijmegen Department of Spine Surgery, Faculty of Health Sciences, Linköping University, Linköping Department of Medical and Health Sciences, Linköping University, Linköping Department of Clinical Neuroscience and Rehabilitation/Physiotherapy, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden Department of Physiotherapy and Occupational Therapy, Sahlgrenska University Hospital, Gothenburg Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen Department of Computer Science and Automation, Indian Institute of Science, Bangalore 560 012, India Research Unit for Immunoinformatics, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Kanagawa 230- 0045, Japan Department of Biotechnology and Bioinformatics, Kuvempu University, Jnanasahyadri, Shimoga 577 451, India Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India Department of Medical Informatics, National Defense Medical College, Saitama 359-8513, Japan Department of Human Genome Technology, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba 292-0818, Japan Laboratory for Immunogenomics, Research Center for Allergy and Immunology, RIKEN, Yokohama Institute, Japan McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N. Broadway, BRB Room 527, Baltimore, MD 21205 Department of Pathology, Sarcoma Center Berlin-Brandenburg, Germany Department of Hematology, Oncology and Palliative Care, Sarcoma Center Berlin-Brandenburg, Helios Klinikum Bad Saarow, Bad Saarow Department of Orthopedic Oncology, Sarcoma Center Berlin-Brandenburg, Helios Klinikum Berlin-Buch, Berlin Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, Assam 784 028, India Department of Computer Science and Engineering, Tezpur University, Tezpur, Assam 784 028, India Department of Mathematical Sciences, Tezpur University, Tezpur, Assam 784 028, India Japan International Center of Agricultural Sciences, Ibaraki 305-8686, Japan RIKEN Plant Science Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK Redpath Museum and Department of Biology, McGill University, 859 Sherbrooke Street West, Montreal, QC H3A 2K6, Canada Duke University Marine Laboratory, Nicholas School of the Environment and Earth Sciences, 135 Duke Marine Lab Road, Beaufort, NC 28516-9721, USA Department of Cardiology, Bedford Hospital NHS Trust, Kempston Road, Bedford, MK42 9DJ, UK Department of Acute Medicine, Ipswich Hospital NHS Trust, UK Department of Prosthodontics, Faculty of Dentistry, Süleyman Demirel University, 32200, Isparta, Turkey Department of Anesthesiology, University of Toledo, College of Medicine, 3000 Arlington Avenue, Toledo, OH 43614, USA Department of Medical Microbiology and Immunology, University of Toledo, College of Medicine, 3000 Arlington Avenue, Toledo, OH 43614, USA Department of Pathology, University of Toledo, College of Medicine, 3000 Arlington Avenue, Toledo, OH 43614, USA Department of Dermatology, University of Toledo, College of Medicine, 3000 Arlington Avenue, Toledo, OH 43614, USA Department of Orthodontics, Rheinische Friedrich-Wilhelms-University, Bonn, Germany Department of Orthodontics, Johannes-Gutenberg University, Mainz, Germany Department of Operative Dentistry and Periodontology, Johannes-Gutenberg University, Mainz, Germany Department of Biochemistry, University of Catania, Catania Department of Experimental and Clinical Pharmacology, University of Catania, Catania, Italy Department of Pediatrics, University of Catania, Catania, Italy Department of Neurosurgery, Firat Universitesi, Tip Fakultesi, Firat Tip Merkezi, Beyin Cerrahi Klinigi, 23200, Elazig, Turkey Department of Radiology, Policlinico San Matteo - University of Pavia, Pavia (27100), Italy Section of Neurosurgery, King Khalid National Guards Hospital, Jeddah, Saudi Arabia University of Nottingham, Faculty of Medicine and Health Sciences, Medical School, Queen's Medical Centre, UK Department of Medical Oncology, Pitié-Salpêtrière Hospital Group, Paris, France Department of Medical Oncology, National institute of Oncology, Rabat, Morocco Department of Surgery, Yeovil District Hospital Foundation Trust, Higher Kingston, Yeovil, Somerset Department of Surgery, Sapienza University of Rome, Andrea Hospital, Italy Department of Neurology, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK A&E Department, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK Department of Gastroenterology, Royal Blackburn Hospital, UK University of Manchester, Oxford Road, Manchester, M13 9PL, UK Department of Gastroenterology, Rochdale Infirmary Department of Orthopaedic Surgery, Iizuka Hospital, Iizuka, 820-8505, Fukuoka, Japan Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Fukuoka, Japan Laboratory of Tropical Crop Improvement, Katholieke Universiteit Leuven, Kasteelpark Arenberg 13, B-3001 Leuven, Belgium Centre of the Region Hana´ for Biotechnological and Agricultural Research, Institute of Experimental Botany, Sokolovska´ 6, Olomouc CZ-77200, Czech Republic Research Associate, Tampa General Hospital, Florida Gulf to Bay Anesthesiology Associates, PA, Tampa, Florida, USA Department of Cardiovascular Medicine, Cairo University Hospital, Cairo, Egypt, Visiting Scholar at Tampa General Hospital, Florida Gulf to Bay Anesthesiology Associates, PA, Tampa, Florida, USA Department of Orthopaedic Surgery, Darrent Valley Hospital, Darftford, London, UK Department of Orthopaedic Surgery, Guy's and St Thomas's Hospital, London, UK Department of Pathologym, Istanbul University, Cerrahpasa Medical Faculty, Kocamustafapasa, Turkey Department of Radiology, Chi-Mei Medical Center, 901 Chung Hwa Road, Yung Kang City, Tainan, Taiwan 710 Department of Neurosurgery, Chi-Mei Medical Center Clinical and Molecular Genetics, Institute of Child Health, University College London, London WC1N 1EH Department of Medical and Molecular Genetics, King's College London, London SE1 9RT, UK Department of Clinical Surgical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad, West Indies Department of Home Science, University of Rajasthan, Jaipur 302004, India Department of Orthopaedics, Gulhane Military Medical Academy, Etlik, Ankara, Turkey Department of Radiology, Faculty of Medicine, Firat University, Turkey Department of Cardiology, S¸ifa Hospital, Erzurum, Turkey Department of Cardiovascular Surgery, Faculty of Medicine, Firat University, 23119, Elazig, Turkey Department of Pathology, National Hospital Organization Mito Medical Center, 280 Sakuranosato, Ibaraki, 311-3193 Central Clinic of Athens - Diagnostic and Treatment Center, Asklepiou 31 str, 106-80 School of Natural Sciences, University of Western Sydney, Penrith, New South Wales 1797, Australia National Oceanography Centre, University of Southampton, Southampton, UK Integrative Biology Section, University of Texas at Austin, Austin, TX Orthodontics, Faculty of Dentistry, 2/F Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong SAR, China Dental Department, Doha-Qatar Hamad Medical Corporation, Doha, Qatar Department of Physiology, Anatomy and Genetics, University of Oxford Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast BT9 7BL, UK Department of Molecular and Cellular Biology, University of Cape Town, Rondebosch, South Africa Department of Orthopaedics and Traumatology, Goztepe Research and Training Hospital, Fahrettin Kerim Gokay street. Kadikoy/ Istanbul post code 34722, Turkey School of Computer Science and Electronic Engineering, University of Essex, Colchester CO4 3SQ, UK Department of Physics, University of Strathclyde, UK University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Institute of Reproductive Medicine, University of Mu¨nster, Mu¨nster, Germany Prince Henry's Institute of Medical Research, Level 4, 43-51 Kanooka Grove, Clayton, Victoria, 3168 Australia Service de Ne´phrologie, Universite´ Claude-Bernard Lyon 1, Hoˆpital Edouard-Herriot, Lyon, France Service de Ne´phrologie, Hopital Calmette, Lille, France Department of Nephrology, Fukuoka Red Cross Hospital, Fukuoka, Japan Division of Nephrology, Showa University School of Medicine, Tokyo The Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan Department Of Orthopaedics, James Cook University Hospital, Middlesbrough, TS4 3BW, UK Department of Cellular Pathology, Lincoln County Hospital, Greetwell Road, Lincoln, United Kingdom, LN 2 5 QY Department of Colorectal Surgery, Scunthorpe General Hospital, Cliff Gardens, Scunthorpe, North Lincolnshire, United Kingdom, DN 15 7 BH Faculty of Life and Health Sciences, University of Ulster, Jordanstown Campus, Shore Rd, Newtownabbey BT37 0QB, Northern Ireland Department of General Surgery, Daisy Hill Hospital, Newry BT35 8DR, Northern Ireland Department of Anatomy, Melaka Manipal Medical College (Manipal Campus), Manipal University, Manipal, Karnataka, India Department of Anatomy, Kasturba Medical College, Manipal University, Manipal, Karnataka, India Department of Anatomical Sciences, St. Matthew's University School of Medicine, P. O. Box 30992 SMB KY1-1204, Grand Cayman, Cayman Islands, BWI Department of Anatomy, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India Hubrecht Institute-KNAW & University Medical Center Utrecht and Interuniversity Cardiology Institute of The Netherlands, 3584 CT Utrecht, The Netherlands Plant Science Center, RIKEN, Yokohama, Kanagawa 230-0045 Department of Biology, Graduate School of Science, Kobe University, 1-1 Rokkodai, Kobe 657-8501, Japan State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing 100052, People's Republic of China Department of Chemistry, Yale University, USA Department of Medicine, Musgrove Park Hospital, UK Department of Anatomy, Medical School, Aristotle University of Thessaloniki, P. O. Box: 300, 54124 Thessaloniki, Greece Department of General Surgery, Santa Maria Nuova Hospital, ASL 10 Firenze, Italy Department of Radiology, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria Department of Urology, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria Radiology Department, Democritus University of Thrace, University General Hospital Dragana, 68100 Alexandroupolis, Greece Gastrointestinal Endoscopy Unit, Democritus University of Thrace, University General Hospital Dragana, 68100 Alexandroupolis, Greece Transplantation Unit, Gazi University Medical Faculty, Ankara, Turkey Department of Anesthesia and Reanimation, Gazi University Medical Faculty, Ankara Biotechnology and Biological Sciences Research Council, Polaris House, North Star Avenue, Swindon, Wiltshire SN2 1UH School of Chemistry and Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess St, Manchester M1 7DN Department of Pathology, Maulana Azad Medical College and Lok Nayak Hospital, Bahadur Shah Zafar Marg, New Delhi -110002, India Department of Surgery, University Hospital of Ioannina, School of Medicine, Ioannina, Greece Department of Emergency Medicine, University Hospital of South Manchester, Southmoor Road Wythenshawe, M23 9LT, UK Department of Anaesthetics, Central Manchester & Manchester Childrens University Hospitals NHS Trust, Oxford Road, Manchester, M13 9WL, UK Department of Ophthalmology, University of Medical Sciences, Długa 1/2, 61-848 Poznań Department and Clinic of Tropical and Parasitic Diseases, University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznań, Poland Department of Surgery, Faculty of Medicine, Sri Lanka Department of Pediatric Surgery IMS, BHU, Varanasi - 221005 Department of ENT, IMS, BHU, India Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka Department of General Surgery, Scunthorpe General Hospital, Scunthorpe DN15 7BH, UK Department of Endoscopy and Motility Unit, G. Gennimatas General Hospital, Thessaloniki, Greece Universite´ Paris Decartes, Sorbonne Paris Cite´, Paris, France CNRS, UMR8104, Paris INSERM, U1016, Institut Cochin, Paris, France INSERM, UMR1033, Universite´ de Lyon, Lyon, France Respiratory Intensive Care Unit, Western Galilee Hospital-P. O. B. 21, Nahariya 22100, Israel Internal Medicine B Department, Ziv Medical Center, P. O. B. 1008, Safed 13100, Israel Department of Internal Medicine, IJsselland Hospital, Capelle aan den IJssel, The Netherlands Department of General Surgery, Leighton Hospital, Mid Cheshire Hospitals NHS Foundation Trust, Crewe, CW1 4QJ, UK Department of Internal Medicine, Interbalkan European Medical Center, Asklipiou 10, 570 01 Pylaia, Thessaloniki, Greece Propedeutic Surgical Department, AHEPA University Hospital, Aristotle's University of Thessaloniki, St. Kiriakidi 1, 546 36 Thessaloniki, Greece Department of Surgery, Interbalkan European Medical Center, Asklipiou 10, 57 001 Pylaia, Thessaloniki, Greece First Propedeutic Surgical Clinic, AHEPA Hospital, Aristotle University, S. Kiriakidi1, Thessaloniki, 54636, Greece Department of Pathology, AHEPA Hospital, Aristotle University, S. Kiriakidi1, Thessaloniki, 54636, Greece First Propedeutic Department of Internal Medicine, AHEPA Hospital, Aristotle University, S. Kiriakidi1, Thessaloniki, 54636 Department of Clinical Surgery, Trinity Centre, Trinity College Dublin and St. James's Hospital, Ireland Mercy Ruan Neurology Clinic, Des Moines, IA 50314, USA Department of Neurology, NB-302, Baylor College of Medicine, USA Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA Membrane Biology Laboratory, VA Greater Los Angeles Healthcare System, West LA Medical Center, 11301 Wilshire Boulevard, Building 113, Room 324, Los Angeles, CA 90073, USA and David Geffen School of Medicine, UCLA Division of Neonatal Medicine, Department of Pediatrics, New York University Medical Center, Tisch Hospital/ Bellevue Medical Center, USA Division of Neonatal Medicine, Department of Pediatrics, Stony Brook University School of Medicine, Health Science Tower 11-060, Stony Brook, NY 11794, USA Department of Orthopaedics, Royal Hobart Hospital, Liverpool St, Hobart, Tasmania 7000, Australia Department of Surgery, Launceston General Hospital, Charles Street, Launceston, Tasmania 7000, Australia ENT Department, Basildon Hospital, Essex, SS16 5NL, UK Colchester General Hospital, Essex, CO4 5JL, UK Centre for Research into Ecological and Environmental Modelling, School of Mathematics and Statistics, University of St Andrews, St Andrews, Fife KY16 9LZ, UK Department of Aquaculture and Fish Biology, Ho´lar University College, Ha´ eyri 1, 550 Sauða´ rkro´kur, Iceland School of Biology, Scottish Oceans Institute, University of St Andrews, St Andrews, KY16 8LB, UK Department of Ecology and Evolution, State University of New York, Stony Brook, NY 11794-5245, USA Department of Urology, General Hospital of Agia Olga, Athens, Greece Department of Urology, University Hospital of Patras, Patra, Greece Department of Urology, General Hospital of Chios Skilitseio, Chios, TK 82100 Department of Pediatrics, Nobles Hospital, Isle of Man, IM4 4RJ Department of Pediatrics, Glan Clwyd Hospital Bodelwyddan, Rhyl, Denbighshire, LL18 5UJ, UK General Surgery Department, Central Middlesex Hospital, Acton Lane, Park Royal, NW10 7NS and Imperial College, London Haydom Lutheran Hospital, P. O. Mbulu, Haydom via Mbulu, Tanzania Department of Paediatrics, St. -Franziskus-Hospital, Robert-Koch-Str. 55, D-59227 Ahlen, Germany Department of Medicine, The Civil Hospital (Baba-e-Urdu Road), Karachi (74400), Pakistan Department of Surgery, The Aga Khan University Hospital (Stadium Road), Pakistan Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, UK National Heart and Lung Institute, Imperial College, London, UK Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Germany Centre for Clinical and Basic Research, IRCCS San Raffaele, Rome, Italy Cardiovascular Research Centre, Mount Sinai School of Medicine, New York, NY, USA Institute for Molecular and Cellular Physiology, Hannover Medical School, Hannover, Germany Pathology Laboratory [Stichting Laboratoria voor Pathologie en Medische Microbiologie (Stichting PAMM)], Michelangelolaan 2, 5623 EJ, Eindhoven, The Netherlands Department of Neonatology, Máxima Medical Center, PO Box 7777, 5500 MB, Veldhoven, The Netherlands Orthopaedic Hospital of Speising, Paediatric Department, Vienna, Austria Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and, AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital, Vienna, Austria Orthodontics, Faculty of Dentistry, The University of Hong Kong, 2/F, 34 Hospital Road, Sai Ying Pun, Hong Kong SAR, PR China Department of Medicine, St. Luke's - Roosevelt Hospital, Columbia University College of Physicians and Surgeons, 1000 Tenth Ave New York, NY 10019, USA Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada Pediatric Centre for Weight and Health, Stollery Children's Hospital, Edmonton, AB, Canada Department of Hematology, Clínica Universidad de Navarra, Pamplona, Spain Department of Nuclear Medicine, Clínica Universidad de Navarra, Spain Department of Oncology, Clínica Universidad de Navarra, Pamplona, Spain Department of Endoscopy and Motility Unit, G. Gennimatas General Hospital of Thessaloniki, Ethnikis Aminis 41, Thessaloniki, Greece Department of Medicine, Division of Infectious Diseases, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY 10305, USA National Institute of Cardiovascular Diseases, Bratislava, Slovakia Cardiology Department, Masaryk Hospital, Usti nad Labem, Czech Republic Cardiocenter, Third Faculty of Medicine, Charles University Prague, Czech Republic National Institute of Public Health, Prague, Czech Republic Department of Urology, University Hospital of South Manchester Foundation NHS trust, Wythenshawe Hospital, Southmoor Road, Manchester, M13 0DP Department of Urology, Narita Red Cross Hospital, Japan Department of Radiology, Asahi General Hospital, 1326, i, Asahi-shi, Chiba 289-2511, Japan Department of Radiology, Saitama Red Cross Hospital, 8-3-33, Kamiochiai, Chuo-ku, Saitama-shi, Saitama 338-8553, Japan Department of Radiology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, USA School of Physical Education and Sport, University of Sa˜o Paulo, Sa˜o Paulo, SP 05508-900, Brazil Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA Haematology Department Laiko General Hospital of Athens, 17 Agiou Thomas St. GR-15727 Goudi, Athens, Greece Cardiac Department, Laiko General Hospital of Athens, 17 Agiou Thomas St. GR-15727 Goudi, Athens Gulhane Military School of Medicine, General Dr. Tevfik Sag˘lam Cad. Etlik/Ankara Department of Orthopaedics and Traumatology, Dumlupinar University School of Medicine, Tavsanli yolu 10. km. 43270, Kutahya, Turkey Department of Haematology and University Hospital of Heraklion, Heraklion, Crete, Greece Department of General Medicine, Sri Ramachandra University, Chennai, Tamil Nadu, India Cell Biology Laboratories, Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK Department of Orthopaedics and Trauma, Altnagelvin Area Hospital, 700 Glenshane Road, Londonderry, Northern Ireland, BT47 6SB, UK Department of Psychology, Karlstad University, SE-651 88, Karlstad, Sweden Department of Internal Medicine, University of Tennessee College of Medicine, Chattanooga 960 East Third Street, Suite 208, TN 37403, USA Department of Internal Medicine, Kita-Kyusyu General Hospital, 5-10-10, Yukawa, Kokura-minami-ku, Kitakyusyu-shi, Fukuoka 800-0257, Japan Department of Respiratory Medicine, Chugoku Rosai General Hospital, 1-5-1, Hiro-tagaya, Kure-shi, Hiroshima 737-0193, Japan Department of Obstetrics and Gynecology, Sri Ramachandra University, Chennai, India Department of General Medicine, Sri Ramachandra University, Chennai Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco Department of Pediatrics, Monmouth Medical Center, 300 Second Avenue, Long Branch, New Jersey Department of Medicine, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, USA Athens Medical International, Lykavittou 6, Kolonaki, Athens, Greece Department of Radiology, Gulhane Military Medical Academy, Ankara, Turkey Federal University of Vale do São Francisco, Faculty of Medicine, Av. José de Sá Maniçoba, S/N - CEP: 56304-917 - Petrolina/PE, Brazil Federal University of Ceará, Faculty of Medicine, Rua Aleandre Baraúna 949, Brazil Institute of Psychiatric Rehabilitation Villa S. Agata, Via Rimembranze 36, 89131 Gallina, Reggio Calabria, Italy Department of Orthopedics and Trauma, University of Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany Department of Surgery and Trauma, University of Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany Department of vascular surgery, Lincoln County Hospital, Greetwell Road, Lincoln, LN2 5QY Interdisciplinary Tinnitus Treatment and Research Center, University of Regensburg, Germany Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstrasse 84, 93053 Regensburg Department of Otorhinolaryngology, University of Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany Department of Medicine, University of Tennessee, College of Medicine, 975 East Third Street, Suite 94, Chattanooga, TN 37403, USA Department of Orthopaedics, Government Hospital for Bone and Joint Surgery Barzullah, Srinagar, 190005, India Department of Surgery, Hospital of St. Raphael, 1450 Chapel Street, New Haven, CT 06511, USA Department of Radiology, Faculty of Medicine, Fluminense Federal University Department of Medical Biotechnology and Legal Medicine, Division of Radiological Science, University of Palermo, Interdepartmental Unit for Hepatic Neoplasia Group, Via del Vespro 129, 90127 Palermo, Italy Department of Clinical Medicine and Emerging Pathologies, Division of Internal Medicine and Hepatology, University of Palermo, Interdepartmental Unit for Hepatic Neoplasia Group, Via del Vespro 129, 90127 Palermo, Italy Department of Oncology, Division of General and Oncological Surgery, University of Palermo, Interdepartmental Unit for Hepatic Neoplasia Group, Italy Biomedical Department of Internal and Specialised Medicine, Division of Gastroenterology and Hepatology, University of Palermo, Interdepartmental Unit for Hepatic Neoplasia Group, Via del Vespro 129, 90127 Palermo, Italy Department of Cardiology, Dalin Tzu Chi General Hospital, 2, Min-Sheng Road, Dalin, Chia-Yi County, Taiwan Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital Dou-Liou Branch, Taiwan Department of Internal Medicine, National Cheng Kung University Hospital, 138, Sheng-Li Road, Tainan, Taiwan State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, China Parkinson's Disease and Movement Disorders Center of Boca Raton, 951 NW 13th Street, Bldg. 5-E, Boca Raton, Florida 33486, USA Parkinson's Disease and Movement Disorders Center, University of South Florida, 4 Columbia Drive, Suite 410, Tampa, Florida 33606, USA Movement Disorders Program, Medical College of Georgia, Augusta, Georgia 30912, USA Department of Radiology, Mayo General Hospital, Castlebar, Co. Mayo, Ireland Department of Surgery, Mayo General Hospital, Castlebar, Co. Mayo, Ireland Department of Surgery, Kas¸ State Hospital, Antalya Department of Surgery, Faculty of Medicine, Yüzüncü Yil University Graduate program in Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China National Institute of Biological Sciences, Beijing, China Graduate program in School of Life Sciences, Peking University, Beijing, China Department of Orthopaedic and Trauma Surgery, Insubria University, Viale Borri 57, 21100 Varese, Italy Institute of Healthy Ageing and Department of Genetics, Evolution & Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK Doheny Eye Institute, University of Southern California, Los Angeles, CA 90033, USA Department of Botany, Rhodes University, PO Box 94, Grahamstown 6140, South Africa Centre for Applied Mathematics and Computational Science, Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata- 700064 Laboratory of Pathology, General Hospital G. Papanikolaou, Thessaloniki, Greece Department of Thoracic and Cardiovascular Surgery, General Hospital G. Papanikolaou, Thessaloniki, Greece Department of Radiology, General Hospital G. Papanikolaou, Thessaloniki, Greece Department of General Medicine, Virgen de las Nieves University Hospital (Avenida Fuerzas Armadas), Granada (18012), Spain Department of Dermatology, San Cecilio University Hospital (Avenida Doctor Oloriz 18), Granada (18012), Spain Department of Urology, San Cecilio University Hospital (Avenida Doctor Oloriz 18), Granada (18012) Department of Neurosurgery Elazig, Firat Universitesi, Tip Fakultesi, Firat Tip Merkezi, Beyin Cerrahi Klinigi, 23200, Elazig, Turkey Department of Dental Sciences and Surgery, University of Bari, P. zza Giulio Cesare n. 11, Bari, 70124, Italy Department of Nuclear Medicine, University of Munich - Grosshadern, Marchioninistrasse 15, D-81377 Munich, Germany Institute of Clinical Radiology, University of Munich - Grosshadern, Marchioninistrasse 15, D-81377 Munich, Germany Medical Department 2, University of Munich - Grosshadern, Marchioninistrasse 15, D-81377 Munich, Germany Third Department of Pneumonology, Sismanoglio General District Hospital, Athens, Greece Department of Pneumonology, Army General Hospital, Athens, Greece Department of General Surgery, Port-Fouad General Hospital, Al-Obour Street- Port-Fouad, 11361 Department of Gynecology and Obstetrics, Burdwan Medical College and Hospital, Burdwan, West Bengal Department of Pediatrics Medicine, Burdwan Medical College and Hospital, Burdwan, West Bengal, India Division of Cellular and Molecular Medicine, St George's, University of London, London SW17 0RE, UK School of Pharmacy, University of London, UK Department of Orthopaedic Surgery, Taksim Education and Research Hospital, Siraselviler Street No: 112, Postal code: 34433, Beyoglu, Istanbul, Turkey New York College of Osteopathic Medicine, Old Westbury, NY 11568, USA Department of Surgery, Lutheran Medical Center, USA Department of Medicine, Central Hospital, Warri, Delta State, Nigeria Department of Obstetrics and Gynaecology, Faculty of Medicine, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria Department of Radiology, University of Cincinnati Medical Center, 234 Goodman St. , ML 0761, Cincinnati, Ohio 45267 Department of Trauma and Orthopaedics Morriston Hospital, United Kingdom Department of Thoracic Surgery, Chest Disease Hospital, Al-Jabriah, P. O. Box. 718, Kuwait Bacteriology and Mycology, Institute for Infectious Diseases and Zoonoses, Department of Veterinary Sciences, LMU Munich, Germany Fraunhofer Institute for Cell Therapy and Immunology, Cell Technology/GLP, Perlick Strasse 1, 04103 Leipzig, Germany Haematology, Norfolk and Norwich University Hospitals NHS Foundation Trust Department of Diagnostic Radiology, Interbalkan Hospital, 10 Asklipiou st, 57001 Pylaia, Thessaloniki, Greece Department of Medical Oncology, Interbalkan Hospital, 10 Asklipiou st, 57001 Pylaia, Thessaloniki, Greece Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074 Department of Cellular Pathology, Medway Maritime Hospital, Gillingham, ME7 5NY, UK Department of Pathology, Shizuoka City Shimizu Hospital, Miyakami 1231 Shimizu-Ku, Shizuoka 424-8636, Japan Department of Pediatrics, Al Ameen Medical College, Athani Road, Bijapur - 586108 Hematology Unit, Hospital Infante D. Pedro, EPE, Avenida Artur Ravara, 3814-501 Aveiro, Portugal 1st Department of Propaedeutic Surgery, Hippocrateion Hospital, Athens Medical School, Q. Sophia114, 11527, Athens, Greece 2nd Department of Surgery, 417 NIMTS (Military Veterans' Fund Hospital), Greece Mapi Consultancy, Lyon, France Medical Affairs, Fresenius Biotech GmbH, München, Germany Department of Surgery, Nottingham University Hospitals NHS Trust, Nottingham, UK Cardiology Department, St. Peter's Hospital/St. George's, Chertsey, UK St. Elisabeth Klinik, Saarlouis, Germany Cardiology Department, Russels Hall Hospital, Dudley, UK Cardiology Department, Universita¨tsklinikum Wu¨rzburg, Germany Cardiology Department, Barzilai Medical Centre, Ashkelon, Israel Good Hope Hospital, Sutton Coldfield, UK Department of Microbiology, A. H. E. P. A. University Hospital of Thessaloniki, Aristotle's University of Thessaloniki, Thessaloniki, Greece 1st Propedeutic Surgical Clinic, A. H. E. P. A. University Hospital, Aristotle's University of Thessaloniki, Thessaloniki, Greece Department of Orthopaedic Surgery, Deventer Hospital, Nico Bolkesteinlaan 75, 7416 SE Deventer, The Netherlands Department of Family Medicine and Public Health Sciences, Wayne State University, 1100, W. University Drive, Rochester Hills, Michigan 48307, USA Department of Surgery, Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey Department of Trauma & Orthopaedics, Tameside General Hospital, Fountain street, Ashton-Under-Lyne, OL6 9RW, United Kingdom Department of Radiology, Chinese PLA General Hospital, Fuxing Road 28, Beijing, 100853, China Department of Ultrasound, Chinese PLA General Hospital, Fuxing Road 28, Beijing, 100853, China Clinical Division of Nanlou, Chinese PLA General Hospital, Fuxing Road 28, Beijing, 100853, China Department of Radiology, Sunderland Royal Hospital, Kayll Road, Sunderland SR4 7TP, UK Department of General Surgery, Sunderland Royal Hospital, Kayll Road, Sunderland SR4 7TP, UK Institute of Biomedicine and Centro de Investigacio´n Biome´dica en Red de Enfermedades Hepa´ticas y Digestivas (CIBERehd), University of Leo´n, 24071 Leo´n, Spain Department of Animal Health, University of Leo´n, 24071 Leo´n, Spain Department of Urology, Evagelismos General Hospital of Athens, Ipsilandou 45-47, 10676, Athens, Greece Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Iran Department of Gastroenterology, Second Department of Internal Medicine, Ippokration Hospital, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki, 54624, Greece Department of Medicine, University of Tennessee, College of Medicine, Chattanooga, USA Non-communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK Division of Medical Biochemistry, Research Center of CHUQ, L'H oˆtel Dieu de Que´bec Hospital and Faculty of Medicine, Laval University, Quebec, QC, Canada Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan Department of Pathology, Hinchingbrooke Hospital, Huntingdon, PE29 6NT, UK Department of Trauma and Orthopaedic Surgery, Hinchingbrooke Hospital, Huntingdon, PE29 6NT, UK Department of Orthopaedic Surgery, 12 Octubre Hospital, Av. Andalucia s/n, Madrid, 28045, Spain St Paul's Eye Unit, The Royal Liverpool University Hospital, Prescot Street, Liverpool, Merseyside, UK Department of Dermatology, Radboud University Nijmegen Medical Center, René Descartes dreef 1, P. O Box 9101, 6525 GL, Nijmegen, The Netherlands Department of Internal Medicine, Rosalind Franklin University of Medicine & Sciences, Chicago Medical School, North Chicago, Illinois, USA Department of Medicine, Blackpool Victoria Hospital, Blackpool, Lancashire, UK Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran 14197, Iran Department of Pediatric Intensive Care Unit, University Hospital of Heraklion, Heraklion, Crete, Greece Department of Pathology, Ibnsina Hospital, Agdal/Riad, Rabat-10000, Morocco Department of Radiotherapy, National Institute of Oncology University of Ioannina, Department of Physics, University Campus, 45110, Ioannina, Greece University of Ioannina School of Medicine, Department of Hygiene & Epidemiology, University Campus, 45110, Ioannina, Greece Department of Family and Community Medicine, University of Missouri, MA 303 Medical Sciences Building, Columbia, MO 65212, USA Unite´ de recherche en ge´ ne´ tique humaine et mole´ culaire, Centre de recherche de l'Hoˆ pital Saint-Franc¸ ois d'Assise, Universite´ Laval, Que´ bec, QC, Canada G1L 3L5 Department of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8M5 Department of Pathology, Hôpital Tenon, 75020 Paris, France Department of Gynecology, Hôpital Armand-Trousseau, France National Institute of Oncology, IbnSina Teaching Hospital, Rabat, Morocco Department of Pathology, Hassan II Teaching Hospital, Fez Department of Urology, Hassan II Teaching Hospital, Fez Department of Urology, Jichi Medical University MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, UK Department of Oral and Dental Science, University of Bristol, Bristol, UK Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK Department of Clinical Biochemistry, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark Department of Orthopaedics, Mayday Hospital, 530 London Road, Croydon, CR 7 7 YE, UK Department of Orthopaedics, Kingston Hospital, Galsworthy Road, Kingston-upon-Thames, Surrey, KT 2 7 QB, UK Department of Clinical Radiology, Mubarak Al-Kabeer Hospital, Kuwait Division of Surgery I, Department of Surgery, Central Hospital of Bolzano, L. Böhler Street 5, I-39100 Bolzano (BZ), Italy Division of Internal Medicine, Department of Medicine, Central Hospital of Bolzano, L. Böhler Street 5, I-39100 Bolzano (BZ), Italy Department of Anaesthesia, Ulster Hospital, United Kingdom/Northern Ireland Department of Anaesthetics, Antrim Area Hospital, 45 Bush Road, Antrim, BT41 4RD, United Kingdom/Northern Ireland Department of Surgery, University of Melbourne, Australia Department of Medicine, University of Melbourne, Austin Hospital, Austin Health, 145-163 Studley Road, Heidelberg, Victoria, 3084 Ludwig Institute for Cancer Research, University of Melbourne, Austin Hospital, Austin Health, 145-163 Studley Road, Heidelberg, Victoria, Australia, 3084 Department of Radiology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH 44109, USA Department of Family Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH 44109, USA Department of Surgery, Istanbul Education and Research Hospital, Turkey Department of Surgery, Diyarbakir Education and Research Hospital, Op. Dr. Seref Inaloz Caddesi 21400, Diyarbakir Department of Head and Neck Surgery, Gent University, 9000 Gent, Belgium Department of Radiology, AZ Sint-Lucas Hospital, 9000 Gent, Belgium Department of Internal Medicine, Michigan State University/KCMS, 1000 Oakland Dr, Kalamazoo, Michigan 49008, USA Department of Anatomy, Centre for Basic Sciences, Kasturba Medical College, Manipal University, Manipal, Karnataka, India- 576104 Department of Neurodegenerative Disease, UCL Institute of Neurology, PO Box 59, Queen Square, London WC1N 3BG, UK Division of Immune Cell Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK Division of Developmental Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK Department of Urology, Colchester General Hospital, Turner Road, Colchester, Essex, CO4 5JU, UK Department of Hepatogastroenterology, Hospices Civils de Lyon, Hotel Dieu, 1 place de l'Hôpital, 69288 Lyon Cedex 02, France and University Claude Bernard Lyon 1, Lyon, France Department of Internal Medicine, Châlon sur Saône Hospital, 71321 Chalon sur Saône, France Department of Internal Medicine, Hospices Civils de Lyon, Hotel Dieu, 1 place de l'Hôpital, 69288 Lyon Cedex 02, France and University Claude Bernard Lyon 1, Lyon, France Department of Radiology, Hospices Civils de Lyon, Croix Rousse Hospital Department of Biosciences, Aarhus University, Aarhus, Denmark Department of Natural Resources Science, University of Rhode Island, Kingston, RI 02881, USA Department of Invasion Ecology, Institute of Botany, Academy of Sciences of the Czech Republic, Pr u˚honice CZ 252 43, Czech Republic Smithsonian Environmental Research Center, PO Box 28, Edgewater, MD 20137, USA Royal London Hospital, Whitechapel Road, London E1 1BB, UK MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 0QH Department of Pathology, Creighton University Medical Center, Omaha, NE 68131, USA Unit of Stereotactic Radiosurgery, Galliera Hospital, Mura Delle Cappuccine 14, 16128 Genova, Italy Unit of Neurosurgery, Galliera Hospital, Mura Delle Cappuccine 14, 16128 Genova, Italy Department of Endocrinology, Galliera Hospital, Mura Delle Cappuccine 14, 16128 Genova, Italy Department of Oral Biology, Leeds Dental Institute, University of Leeds, Clarendon Way, Leeds LS2 9LU Faculty of Life Sciences and School of Dentistry, Manchester Academic Health Sciences Centre, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK Department of General Surgery, El Sahel Educational Hospital, Cairo, Egypt Department of Trauma and Orthopaedics, Medway Maritime Hospital, Medway, ME7 5NY, UK Internal Medicine, Suny Upstate Medical University, NY 13210, USA Department of Oral and Maxillofacial Surgery, Sri Kumaran Hospital, 1, Link Road, Kottur Gardens, Chennai 600085, India Department of Genetics and Genomic Sciences, Program for Inherited Metabolic Diseases, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, New York 10029, USA Department of Pediatrics, Division of Pediatric Cardiology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1201, New York, New York 10029, USA Department of Zoonotic and Tropical Diseases, Medical University of Warsaw, ul. Wolska 37, 01-201 Warsaw Department of Histopathology, CHU Hassan II, 30000, Fez National Institute of Oncology, Rabat, Morocco Department of Urology, CHU Hassan II, 30000, Fez, Morocco Department of Urology, District General Hospital, Southport PR8 6PN Department of Radiology, District General Hospital, Southport PR8 6PN, UK Regional Spinal Injuries Centre, District General Hospital, Southport PR8 6PN Thoracic Surgery Department, Sismanoglio General Hospital, 1 Sismanogliou Street, 15126 Marousi, Athens, Greece Department of Biosurgery and Surgical Technology, Imperial College London, Imperial College Healthcare NHS Trust at St Mary's Hospital, London, UK Second Cardiac Surgical Department, Evangelismos General Hospital, Ipsilantou Street 45-47, Athens, 106767, Greece Department of Pediatric Surgery IMS, BHU, Varanasi-221005, Uttar Pradesh, India Department of Surgery, SN Medical College, India Department of Anatomical Pathology, Ibn Sina University Hospital, Rabat, Morocco Department of Thoracic Surgery, Ibn Sina University Hospital, Rabat, Morocco Department of Hearing Implant Science, Shinshu University School of Medicine, Matsumoto, Japan Department of Thoracic and Cardiovascular Surgery, Athens Naval and Veterans Hospital, Deinokratous 70 Kolonaki, Athens, Greece Department of Pediatric Medicine, King Abdulaziz Medical City, Riyadh, 11426, Saudi Arabia Department of Pathology & Laboratory Medicine, King Abdulaziz Medical City Riyadh, 11426, Saudi Arabia King Saud bin Abdulaziz University for Health Sciences, College of Medicine, Riyadh, 11426, Saudi Arabia King Abdullah International Medical Research Center, Molecular Biology, King Abdulaziz Medical City, Riyadh, 11426, Saudi Arabia Pathology, Stanford University School of Medicine, USA Department of Surgery, Hospital of St. Raphael, 1450 Chapel Street, New Haven, CT 06511, USA Department of Histopathology, Lincoln County Hospital, Lincoln Department of Surgery, Lincoln County Hospital, Lincoln, UK Department of Cardiac Surgery, University Hospital of Santiago de Compostela, 15706, La Choupana SN, Spain Department of Anatomy, Kasturba Medical College, Manipal, India Department of Anatomy, Asian Institute of Medicine, Science and Technology, Sungai Petani, Kedah, Malaysia Department of Anatomy, Melaka Manipal Medical College, Manipal, India Department of Anatomy, Mamata Medical College, Khammam, India Department of Emergency Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, MEB Room 104, New Brunswick, NJ, USA Obstetrics and Gynecology Department, Medamerican Medical Center, Kadikoy-Istanbul, Turkey Neurosurgery Department, American Hospital, Guzelbahce Sk. No: 20, 34365 Nisantasi - Istanbul, Turkey Istanbul Pathology Center, Valikonagi Cd. No: 125, 34365 Nisantasi - Istanbul, Turkey Department of Otolaryngology, Osaka Central Hospital, Osaka City, Osaka, Japan Department of Otolaryngology, Hyogo College of Medicine, Nishinomiya City, Hyogo University Clinical Centre of Kosova, Department of Otolaryngology, Mother Theresa n. n. , 10000 Prishtina, Republic of Kosova University Clinical Centre of Kosova, Department of Anesthesiology and Intensive Care, Mother Theresa n. n. , 10000 Prishtina, Republic of Kosova Istanbul University, Medicine Faculty Radiology Department, Istanbul, Turkey Radiology Department, American Hospital, Guzelbahce Sk. No: 20, 34365 Nisantasi - Istanbul, Turkey Neurosurgery Department, Pendik State Hospital, Istanbul, Turkey Department of Neurosurgery, Pamukkale University School of Medicine, Bursa cd. No:119, Kinikli, 20070, Denizli, Turkey Department of Neurosurgery, Pendik State Hospital, Dr. Orhan Maltepe cd. No:17, Pendik, 34890, Istanbul Department of Urology, District General Hospital, Southport PR8 6PN, UK Department of Radiology, District General Hospital, Southport PR8 6PN, UK Regional Spinal Injuries Centre, District General Hospital, Southport PR8 6PN, UK Department of Obstetrics & Gynecology, Lady Hardinge Medical College and Smt Sucheta Kriplani Hospital, New Delhi 110 001, India Department of Obstetrics & Gynecology, Princess Alexandra Hospital, Harlow, Essex, CM20 1QX, UK Neuroradiology Department, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, West Midlands, UK Oncology Department, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, West Midlands, UK Canadian Registered Nurses Association of B. C. , Vancouver Coastal Health Authority, 2755 Arbutus Street, Vancouver, B. C. , Canada Department of Pathology and Laboratory Medicine, Heather Pavilion, Vancouver General Hospital, Vancouver, B. C. , Canada Department of Medical Cannabis Research, The Green Cross Society of BC, 2127 Kingsway, Vancouver, B. C. , V5N 2T4, Canada Department of Medicine, Norfolk and Norwich University Hospital, Norwich, UK Institute of Pathology, University Hospital Giessen and Marburg, Location Marburg, Baldingerstrasse, 35033 Marburg, Germany Centre for Molecular Medicine, University College London, London, UK Department of Surgery, Barnet General Hospital, London, UK Department of Rheumatology, City Hospital, Birmingham, UK Department of Pharmacognosy, Institute of Pharmaceutical Sciences, Karl Franzens University Graz, Universita¨tsplatz 4, A-8010 Graz, Austria Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, 29 - 39 Brunswick Square, London WC1N 1AX, UK Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, Karl Franzens University Graz, Universita¨tsplatz 1, A-8010 Graz, Austria Department of Medical Microbiology, Royal Free Hospital, University College London, Rowland Hill Street, London NW3 2PF, UK Department of Orthopaedics, The First Affiliated Hospital, Xinjiang Medical University, China Orthopaedic Laboratory, Clinic Medical Research Institution, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, NO. 3 Qingchun Road, Hangzhou, 310016, Zhejiang Province, China Department of Internal Medicine, Gulhane Military Medical Academy, Tevfik Saglam Street, Ankara, 06010, Turkey Department of Pathology, Inonu University Faculty of Medicine, Malatya-Elazig Street Malatya, 44069 Department of Hematology, Inonu University Faculty of Medicine, Malatya-Elazig Street, Malatya, 44069 Department of Surgery, Sri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9 Burns and Plastics Surgery Department, Morriston Hospital, Morriston, Swansea, Wales, SA6 6NL, UK Surgical Department, Chesterfield Royal Hospital, Chesterfield Road, Chesterfield, S44 5BL, UK Department of Histopathology, Royal Brompton and Harefield NHS Trust, Harefield, Middlesex, UB9 6JH, UK Department of Respiratory Medicine, Heatherwood and Wexham Park Hospitals NHS Foundation Trust, King Edward VII Hospital, Windsor, Berkshire, SL4 3DP, UK Department of Medical Education, Florida Hospital East Orlando Medical Plaza, 7975 Lake Underhill Road, Suite 200, Orlando, FL 32822, USA Unit of Oral and Maxillofacial Surgery, UCL Eastman Dental Institute, 256 Grays Inn Road, London, WC1X 8LD, UK Department of Endodontics, School of Dentistry, Aristotle University, Thessalonica, 541 23, Greece Department of Oral Surgery, Surgical Implantology and Radiology, School of Dentistry, Aristotle University, Agiou Dimitriou Street, Thessalonica, 541 24, Greece Private Dentist, Thessalonica, Greece Department of Surgery, University College School, Gower Street, London, WC1E 6BT, UK Head and Neck Centre, University College London Hospital, 253 Euston Road, London, NW1 2BU, UK Department of Dermatology, Leeds General Infirmary, Leeds, UK Department of Breast and Oncoplastic Surgery, Leeds General Infirmary, Leeds LS1 3EX, UK Addenbrooke's University Hospital, Cambridge, UK Highland NHS Trust, Inverness, Scotland, UK Department of Cardiology, Army Veterans Hospital, Athens University of Cambridge, Cambridge, UK Centre for Digestive Diseases, Queen Mary, University of London, E1 2AT, UK NHS Highlands, Belford, UK Department of Surgery, General Hospital, Port-of-Spain, Trinidad, West Indies Department of Anaesthesia and Intensive Care Medicine, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK Department of General Medicine, Sri Ramachandra University, Porur, Chennai-600116, Tamil Nadu Department of Radiology, St. Claraspital, Kleinriehenstrasse 30, CH-4016 Basel, Switzerland Pathology Viollier, Jacob Burckhardt-Strasse 86, Postfach, CH-4002 Basel Department of Surgery, St. Claraspital, Kleinriehenstrasse 30, CH-4016 Basel, Switzerland Urology Unit, St. Claraspital, Kleinriehenstrasse 30, CH-4016 Basel, Switzerland Department of Orthopaedics and Trauma Surgery, University of Thessaly, Larissa Department of Radiology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis (Dragana), 68100, Greece Laboratory of Pediatric Endocrinology, BoNetwork, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy Department of Pediatrics, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy Pathology Department, Papageorgiou Hospital, Thessaloniki, Greece 2nd Academic ORL Department, Papageorgiou Hospital, Thessaloniki, Greece Department of Gastroenterology, University of California Irvine Medical Center, 101 The City Drive, Orange CA 92868, USA Department of General Surgery, University of California Los Angeles Medical Center, 200 UCLA Medical Plaza, Los Angeles, CA 90095, USA Department of Internal Medicine, University of California Davis Health System, 4860 Y Street, Sacramento, California 95817, USA Chia-Yi Christian Hospital and Institute of Biomedical Science, National Chung-Cheng University, No. 539, Chung-Shiao Rd, Chia-Yi City, Taiwan Department of Surgery, Chia-Yi St Martin De Porres Hospital and Institute of Biomedical Engineering, National Chiao-Tung University, No. 565, Sec 2, Da-Ya Rd, Chia-Yi City, Taiwan Department of Pathology, Sismanoglion General Hospital, Brilissia, Athens, Greece First Department of General Surgery, Pireaus General Hospital Tzaneio, Piraeus, Athens, Greece Pendeli Children's Hospital, Palaia Pendeli, Athens, Greece Department of Anatomy, Nursing Faculty, University of Athens, Athens, Greece Department of Urology, University of Florida, Gainesville, FL, USA Department of Urology, Aichi Medical University School of Medicine, Nagakute-cho, Aichi 480-1195, Japan Department of Family Medicine, Cukurova University Faculty of Medicine, Balcali 01330, Adana, Turkey Department of Orthopedics and Traumatology, Medical Faculty of Istanbul University, Istanbul Department of Orthopedics and Traumatology, Goztepe Research and Training Hospital, Istanbul, Turkey Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan Faculty of Medicine, University of Prishtina, Prishtina, Kosovo Orthopaedic Department, University Clinical Center, Prishtina, Kosovo Department of Trauma Surgery, Community Hospital Reutte, Reutte, 6600, Austria Department of Radiology, Medical University Innsbruck, Anichstrasse 35, Innsbruck, 6020, Austria Department of Urology, Medical University Innsbruck, Anichstrasse 35, Innsbruck, 6020, Austria Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA Department of Veterinary Services, Ministry of Agriculture, Putrajaya, Malaysia Universiti Putra Malaysia, Serdang, Selangor, Malaysia Department of Veterinary Services, Veterinary Research Institute, Ipoh, Perak, Malaysia Department of Pathology, Cancer Institute, Imam-Khomeini Hospital, Blouvar Keshavarz Street, Tehran University of Medical Sciences, Tehran, 1136746911, Iran Department of Oral and Maxillofacial Pathology, Faculty of Dentistry and Dental research center, Mashhad University of Medical Sciences, Mashhad, postal code:91735, Iran Department of Oral Medicine, Faculty of Dentistry and Dental research center, Mashhad University of Medical Sciences, postal code:91735, Iran Department of Oral Medicine, Faculty of Dentistry and Dental research center, Vakilabad Blvd, Mashhad, postal code:91735, Iran Geriatrics Division, AIIMS, New Delhi 110029, India 1st Orthopaedic Department of Evangelismos Hospital, Athens, Greece Department of Neurosurgery, Patras University Hospital, Greece Department of Radiology, Patras University Hospital, 26500 Rion, Patras, Greece Department of Internal Medicine, Patras University Hospital, 26500 Rion, Patras, Greece Department of Rheumatology, Musgrove Park Hospital, Taunton, TA1 5DA, UK Scientific Institute for Quality of Healthcare, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of General Practice and Health Services Research, University of Heidelberg Hospital, Heidelberg, Germany Address reprint requests to: Joachim Szecsenyi, AQUA-Institute for Applied Quality Improvement and Research in Healthcare, Goettingen, Germany AQUA-Institute for Applied Quality Improvement and Research in Healthcare, Goettingen, Germany Department of Pathology, 18101 Lorain Avenue, Fairview Hospital, USA Department of Urology, Wirral University Teaching Hospital, Wirral, Merseyside, UK Department of General Surgery, Hinchingbrooke NHS Trust Hospital, Huntingdon, PE29 6NT, UK Department of Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, 333 Cedar Street, 3FMP New Haven, Connecticut, 06520, USA Department of Paediatrics, Institute of Child Health, IRCCS Burlo Garofolo and University of Trieste, Trieste, Italy Department of Surgery, Sahel Educational Hospital, Cairo, Egypt Department of Orthopaedics, The Fourth Affiliated Hospital, Xinjiang Medical University, Xinjiang, 830002 Orthopaedic laboratory, Clinic Medical Research Institution, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No. 3 Qingchun Road, Hangzhou, 310016, Zhejiang Province, China Faculty of Medicine, University of Prishtina, Mother Theresa str. p. n. , Prishtina, 10000, Republic of Kosovo University Clinical Centre of Kosova, Rrethi Spitalit str. p. n. Prishtina, 10000, Republic of Kosovo Department of Orthopedics, Government Medical College, (Bakshinagar), Jammu, Jammu & Kashmir - (180001), India Department of Internal Medicine, Osaka City General Hospital, Osaka, Japan Research Center for Infectious Diseases, University of Wu¨rzburg, Josef-Schneider-Straße 2/D15, 97080 Wu¨rzburg, Germany Institute of Phytopathology and Applied Zoology at the Interdisciplinary Research Center, Justus-Liebig University of Gießen, Heinrich-Buff-Ring 26-32, 35392 Gießen Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Bioresources Project Group, Winchesterstraße 2, 35394 Gießen, Germany Department of Biochemistry & Biophysics, University of California, San Francisco, S-412C Genentech Hall, 600 16th Street, San Francisco, CA 94158-2517, USA Institute for Interdisciplinary Research (IRIBHM), Université Libre de Bruxelles (ULB), Campus Erasme, 808 Route de Lennik, B-1070 Brussels, Belgium Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA Department of Genome Integrity, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic Department of Medical Oncology, University Medical Center, Utrecht, the Netherlands Department of Zoology, Oxford University, Oxford OX1 3PS, UK Nuffield Laboratory of Ophthalmology, Oxford University, Oxford OX3 9DU, UK The Roslin Institute, Edinburgh University, Edinburgh EH25 9PS, UK Research Technology Centre, University of Kiel Psychology Department, Memorial University, St. John's, Newfoundland, Canada Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK Department of Psychological Medicine, Cardiff University, Henry Wellcome Building for Biomedical Research in Wales, Heath Park, Cardiff, CF14 4XN, UK Clinical Development Medical Affairs, Cubist Pharmaceuticals, 65 Hayden Avenue, Lexington, MA 02421, USA Statistical Consultant, Cubist Pharmaceuticals, 65 Hayden Avenue, Lexington, MA 02421 Department of Infectious Diseases, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, USA Hereditary Endocrine Cancer Group, Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, and ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Madrid, Spain Department of Nephrology, Albert-Ludwigs-University, Freiburg, Germany The Tumour Bank, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, New South Wales 2145, Australia Leiden Institute of Chemistry, Leiden University, 2300 RA Leiden, The Netherlands CRUK Inositide Laboratory, The Paterson Institute for Cancer Research, Manchester, UK Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden Jan and Dan Duncan Neurological Research Institute, Texas Children Hospital, Houston, TX 77030, USA Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA Telethon Institute of Genetics and Medicine (TIGEM), Naples 80131, Italy Medical Genetics, Department of Pediatrics, Federico II University, Naples 80131, Italy Department of Clinical Laboratory, Hospital de la Ribera, Alzira, Valencia Department of Clinical Laboratory, Hospital Francesc Borja, Gandía, Valencia Department of Public Health, University of Alicante, Spain Department of Clinical Laboratory, Hospital Universitario de San Juan, Alicante, Spain Department of Clinical Laboratory, Hospital General Universitario de Alicante, Spain Department of Clinical Laboratory, Hospital Clinico Universitario, Valencia, Spain Department of Clinical Laboratory, Hospital La Fe, Valencia, Spain Department of Clinical Laboratory, Hospital de Requena, Valencia, Spain Department of Information Systems, Roche Diagnostics, Valencia, Spain Department of Clinical Laboratory, Hospital General Universitario de Valencia, Spain Department of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, P. 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China Department of Medicine, Uppsala University Hospital AstraZeneca, Gothenburg, Sweden Department of Radiology, Uppsala University Hospital, Sweden Department of Orthopedic Surgery, Fukushima Medical University, Fukushima, Japan School of Health Sciences, Akita University, Akita, Japan Department of Orthopedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan Department of Orthopedic Surgery, Iwate Medical University, Morioka, Japan Department of Orthopedic Surgery, National Cancer Center, Tokyo, Japan Department of Orthopedic Surgery, Juntendo University, Tokyo, Japan Department of Surgical Sciences/Anesthesiology and Intensive Care Medicine, Uppsala University Hospital, Uppsala, Sweden Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology Section, Uppsala University, Uppsala, Sweden Department of Orthopedic Surgery, Nakadori General Hospital, 3-15 Minamidoori-Misono, Akita 010-8577, Japan Department of Orthopedic Surgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan South Akita Orthopedic Clinic, Seiwakai, 96-2 Kaidousita, Syowa-Ookubo, Katagami 018-1401, Japan Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain Department of Medicine, Imperial College London, London, UK Department of Primary Care & Public Health, Imperial College London, London, UK Shire Pharmaceuticals, Wayne, PA, USA Covance Clinical Research Unit Ltd, Leeds, UK Shire Pharmaceutical Development Ltd, Chineham, Hampshire, UK Dante Pazzanese Institute of Cardiology, Sa˜o Paulo, Brazil De´partement de Cardiologie, INSERM U-698, Universite´ Paris 7, AP-HP, Paris Cardiovascular Research, Division of Medical and Radiological Sciences, The University of Edinburgh, Edinburgh, UK University of Massachusetts Medical School, Worcester, MA, USA Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, St Michael's Hospital, University of Toronto, Toronto, ON, Canada Pitie´-Salpeˆtrie`re Hospital, Paris, France Duke University Medical Center, Durham, NC, USA University of Michigan Health System Department of Nuclear Medicine, San Bortolo Hospital, Vicenza Department of Medicine and Cardiology, San Diego VA Medical Center and University of California, San Diego, CA, USA Department of Cardiology, Mayo Clinic, Rochester, MN, USA Division of Nephrology, London Health Sciences Centre, University Hospital, London, Ont, Canada Department of Surgery, The George Washington University, Washington, DC, USA Division of Nephrology, Helsinki University Central Hospital, Helsinki, Finland Trial Coordination Center, Department of Cardiology and Epidemiology, University Medical Center Groningen, Hanzeplein, The Netherlands Department of Cardiology, University of Padova, Padova, Italy UCL Center for Nephrology, Royal Free and University College Medical School, London, UK Department of Internal Medicine, University of Siena, Le Scotte Hospital, Siena Department of Anesthesiology and Critical Care Medicine, Hoˆ pital Lariboisie`re. U 942 Inserm; University Paris 7, Paris Diderot, France Department of Anesthesiology, Duke University Medical Center, USA Department of Critical Care, University of Maryland, College Park, MD, USA Division of Nephrology, Mediciti Hospitals, Hyderabad, India Department of Internal Medicine, San Bortolo Hospital, Vicenza Department of Intensive Care, San Bortolo Hospital, Vicenza, Italy Cardiac Department, Faculty of Public Health, Medical University, Military Hospital, Wroclaw Division of Cardiology, Department of Medicine, Nutrition and Preventive Medicine, William Beaumont Hospital, Royal Oak, MI, USA IRRIV, International Renal Research Institute of Vicenza, Vicenza, Italy Department of Nephrology, University of Colorado Health Sciences Center, Denver, CO, USA Department of Nephrology, San Bortolo Hospital, Viale Rodolfi 37, Vicenza 36100, Italy Department of Cardiology, St Spirito Hospital, Rome, Italy Department of Cardiology, VA Medical Centre, Minneapolis, MN, USA Centre for Clinical and Basic Research, IRCCS San Raffaele, Rome, Italy Department of Cardiology, Applied Cachexia Research, Charite´, Campus Virchow-Klinikum, Berlin, Germany Department of Intensive Care, Austin Hospital, Melbourne, Australia Division of Critical Care Medicine, University of Alberta Hospital, Edmonton, Canada Cardiocenter, 3rd Faculty of Medicine, Charles University Prague, 10034 Prague 10, Czech Republic Cardiology service, University Hospital of Geneva, 23, rue Micheli-du-Crest, 1211 Geneva, Switzerland Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA Department of Vegetable Genetics and Breeding, College of Horticulture, Shenyang Agricultural University, Shenyang 110 161, Liaoning, PR China Department of Life Science, and BK21 Program of Bio-Molecular Function, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea Molecular Genetics and Genomics Lab, Department of Horticulture, Chungnam National University, Republic of Korea Japan International Center of Agricultural Sciences, Ibaraki 305-8686, Japan Kihara Institute for Biological Research, Yokohama City University, 641-12 Maioka-cho, Totsuka-ku, Yokohama, Kanagawa 230-0045, Japan RIKEN Biomass Engineering Program, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan RIKEN Plant Science Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8552, Japan Center for Gene Research, Nagoya University, Nagoya 464-8602, Japan Faculty of Applied Biological Sciences, Gifu University, Yanagido 1-1, Gifu City, Gifu 501-1193, Japan Department of Laboratory Animal Science, Medical College of Jinan University, Guangzhou, Guangdong 510632, People's Republic of China Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Guangzhou, Guangdong 510642, People's Republic of China Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, People's Republic of China Department of Computational Mathematics and Mathematical Physics, Moscow State Technical University n. a. 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Bauman, the 2nd Baumanskaya st. , 5, 105005 Moscow, Russia Institute of Mathematical Problems of Biology, Russian Academy of Sciences, Institutskaya st. , 4, 142290 Pushchino, Russia Department of Colorectal Surgery, Darent Valley Hospital, Darenth Wood Road, Dartford DA2 8DA, UK Inserm E3N-EPIC, Institute Gustave Roussy, Villejuif, France Molecular and Nutritional Epidemiology Unit, CSPO-Scientific Institute of Tuscany, Florence Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark German Institute of Human Nutrition, Potsdam-Rehbu¨cke, Germany Department of Nutritional Research, University of Umea˚, Umea˚, Sweden Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany Public Health & Health Planning Directorate, Asturias, Spain Instituto de Salud Pu´blica de Navarra, Pamplona, Spain Clinical 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Inflammation and Atherosclerosis Research Unit, University Pierre and Marie Curie-Paris 6, Pavillon Benjamin Delessert, Hoˆpital de la Pitie´, 83, Boulevard de l'Hoˆpital, F-75013 Paris Cedex 13, France Department of Psychiatry, Interdisciplinary Center of Psychiatric Epidemiology, University Medical Centre Groningen, University of Groningen, Groningen Department of Health Promotion and Development, Faculty of Psychology, University of Bergen, Bergen, Norway Department of Medical Psychology, CoRPS—Center of Research on Psychology in Somatic diseases, Tilburg University, PO Box 90153, 5000 LE Tilburg, The Netherlands Department of Clinical Chemistry and Clinical Biochemistry, Ludwig-Maximilians-University, Munich 80336, Germany Department of Molecular Pediatrics, Children's Research Center, Dr. von Hauner Children's Hospital, Ludwig- Maximilians-University, Lindwurmstr. 4, Munich 80337, Germany Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA 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Pennsylvania State University, University Park, PA 16802, USA Molecular Cell Biology Program, University of Massachusetts, Lederle Graduate Tower, Amherst, MA 01003, USA Plant Biology Graduate Program, University of Massachusetts, Lederle Graduate Tower, Amherst, MA 01003, USA Department of Biochemistry and Molecular Biology, University of Massachusetts, Lederle Graduate Tower, Amherst, MA 01003, USA BAM, Federal Institute for Materials Research and Testing, Division I. 3, Richard-Willsta¨tter-Strasse 11, 12489 Berlin, Germany GKSS Research Centre at DESY, Petra III, Notkestrasse 85, 22607 Hamburg, Germany Institute of Materials Science and Technologies, Technische Universita¨t Berlin, Englische Strasse 20, 10587 Berlin, Germany REPAIRlab, Institute of Pathology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany Biomaterials Laboratory, Charit´e University Medicine Berlin, Aßmannshauser Strasse 4-6, 14197 Berlin Merck Serono S. A. , Geneva, Switzerland Cardiff Fertility Studies Research Group, School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, Wales, CF10 3AT, UK Faculty of Psychology and Educational Sciences, University of Coimbra, Rua do Cole´gio Novo, Apartado 6153, 3001-802 Coimbra, Portugal Department of Medical Psychology, Radboud University Nijmegen, Medical Centre, PO Box 9101, 6500 HB Nijmegen Maize Research Station, Tamil Nadu Agricultural University, Vagarai 624 613, India Canola Breeders Western Australia Pty Ltd, Locked Bag 888, Como, WA 6952, Australia School of Plant Biology, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia EH Graham Centre for Agricultural Innovation (an alliance between the Charles Sturt University and NSW Department of Primary Industries), Wagga Wagga Agricultural Institute, Wagga Wagga, NSW 2650 Saaten-Union Biotec GmbH, Hovedisser Str. 92, 33818 Leopoldshoehe, Germany Agriculture and AgriFood Canada, Saskatoon Research Centre, 107 Science Place, Saskatoon, SK, Canada, S7N 0X2 Diversity Array Technology Pty Ltd, 1 Wilf Crane, Yarralumla, ACT 2600, Australia The UWA Institute of Agriculture, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia Center for Biological Resources and Informatics, Tokyo Institute of Technology, 4259 B-65 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 B-65 Nagatsuta-cho, Midori- ku, Yokohama 226-8501, Japan CVPath Institute, Gaithersburg, MD, USA Cardiology Section, Dartmouth Medical School/Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China Istituto di Analisi dei Sistemi e Informatica Antonio Ruberti, Consiglio Nazionale delle Ricerche, Viale Manzoni 30, 00185 Rome, Italy Barcelona Institute for Research in Biomedicine (IRB), Barcelona Science Park, C/Samitier 1-5, 08015 Barcelona, Spain Department of Agronomy, Iowa State University, Ames, IA 50011 Department of Entomology, Iowa State University, Ames, IA 50011, USA USDA-ARS, Corn Insect and Crop Genetics Research Unit, 113 Genetics Laboratory, Iowa State University, Ames, IA 50011, USA Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan Policy Ethics and Life Sciences (PEALS) Research Centre, Newcastle University, UK Department of Surgical Sciences, University of Bergen, Norway The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen Banaras Hindu University, Varanasi, India Royal Tropical Institute/Koninklijk Instituut voor de Tropen, Amsterdam, Netherlands Rajendra Memorial Research Institute of Medical Science, Patna Institute of Tropical Medicine, Belgium B. P. Koirala Institute of Health Sciences, Dharan, Nepal Laboratório de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de São Paulo, Brazil Department of Medical Microbiology and Parasitology, University of Khartoum, Sudan Centro de Pesquisas René Rachou-FIOCRUZ, Belo Horizonte, Brazil Ludwig Institute for Cancer Research, Uppsala University, BMC, Box 595, S-751 24 Uppsala, Sweden Edinburgh Royal Hospital for Sick Children, 9 Sciennes Road, Edinburgh EH9 1LF, UK MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK Howard Hughes Medical Institute, and Department of Molecular Biology, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA Weizmann Institute of Science, Rehovot 76100, Israel Departments of Molecular Biology and Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA Surgical Department, Diakonhjemmet Hospital, Oslo, Norway Department of Orthopaedics, Oslo University Hospital, Ullevål Max Planck Institute for Chemistry, Mainz, Germany Biocentre Klein Flottbek and Botanical Garden, University of Hamburg, Department of Biology, Biodiversity of Plants, Ohnhorststrasse 18, 22609 Hamburg, Germany Department of Radiology, Diyarbakir Education and Research Hospital, Diyarbakir 21400, Turkey Department of Pathology, Diyarbakir Education and Research Hospital, Diyarbakir 21400, Turkey Department of Surgery, Diyarbakir Education and Research Hospital, Diyarbakir 21400, Turkey Department of Biological and Biomedical Sciences, University of Durham, South Road, Durham DH1 3LE, UK Biomedical and Environmental Thematic Group, Ifakara Health Institute, PO Box 53, Ifakara Laboratory of Entomology, Wageningen University and Research Centre, PO Box 8031, 6700, Wageningen, The Netherlands Department of Zoology and Marine Biology, University of Dar es Salaam, PO Box 35064, Dar es Salaam, Tanzania School of Population Health, Australian Centre for Tropical and International Health, The University of Queensland, Brisbane 4006, Australia Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK ServiceXS, Plesmanlaan 1d, 2333 BZ Leiden, The Netherlands Leiden Genome Technology Center, Human and Clinical Genetics, Leiden University Medical Center, PO box 9600, 2300 RC Leiden NCB Naturalis - NHN Leiden University, The Netherlands Institute of Biology, Section Plant Ecology and Phytochemistry, Leiden University, PO Box 9505, 2300 RA Leiden National Agricultural Research Center for Kyushu Okinawa Region, 2421 Suya, Koshi, Kumamoto 861- 1192, Japan National Agricultural Research Center for Western Region, 1-3-1 Senyuu, Zentsuuji, Kagawa 765-8508, Japan National Agricultural Research Center for Hokkaido Region, 1 Hitsujigaoka, Toyohira, Sapporo, Hokkaido 062-8555, Japan National Institute of Agrobiological Sciences, 2-1-2 Kannondai, Tsukuba, Ibaraki 305-8602, Japan National Agricultural Research Center for Tohoku Region, 297 Uenodai, Kariwano, Daisen, Akita 019-2112, Japan University of Basel, 4000 Basel, Switzerland Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland Institute of Cell Biology, University of Bern, 3012 Bern, Switzerland Nagahama Institute of Bio-Science and Technology, Tamura-cho 1266, Nagahama-shi, Shiga-ken 526-0829, Japan Division of Biological Sciences and Center for Structural and Functional Neuroscience, The University of Montana, 32 Campus Drive, HS104, Missoula, MT 59812-4824, USA Department of Biochemistry and Molecular Biology, Medical University of South Carolina, USA Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA Department of Biochemistry, La Trobe University, VIC 3086, Australia Universite´ catholique de Louvain, Faculte´ de Me´decine, Unite´ de Pharmacologie cellulaire et mole´culaire, B-1200 Brussels, Belgium Department of Orthopaedic Surgery and Sports Medicine, Linköping University Hospital, Linköping, Sweden Division of Molecular Biosciences, Department of Life Sciences, Imperial College, London SW7 2AZ, UK Stanley Shalom Zielony Nursing Institute, Cleveland Clinic, Cleveland, OH 44195, USA Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard G. 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Sciences, School of Biological Sciences, Zoology Building, University of Aberdeen, Tillydrone Avenue, Aberdeen AB24 2TZ, UK Department of Pediatrics, Tohoku University School of Medicine, Japan Department of Public Health, Chiba University School of Medicine, Chiba, Japan Tanemura Women's Clinic, Nagoya, Japan Institute for Enzyme Research, University of Tokushima, Tokushima, Japan Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden Institute of Child Health, University College London, London, UK Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel Shire Human Genetic Therapies, Inc. , Cambridge, MA, USA Departments of Pediatrics and Neurology, University of Iowa, Iowa City, IA 52242, USA Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44116, USA Institute of Cardiology, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy Klinik fu¨r Innere Medizin III, Abteilung fu¨r Kardiologie, Angiologie und internistische Intensivmedizin, Universita¨tsklinikum des Saarlandes, Kirrberger Strasse, Geba¨ude 40, 66421 Homburg/Saar, Germany Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3 Japan Society for the Promotion of Science, Tokyo 102-8471, Japan Division of Plant Sciences, University of Missouri, Columbia, Missouri 65211, USA Plant Genetics Research Unit, US Department of Agriculture, Agricultural Research Service, USA Nuffield Orthopaedic Centre, Oxford, UK Department of Orthopaedics, Chonnam National University Medical School and Hospital, Gwangju, South Korea Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland Klinik für Orthopädie und Orthopädische Chirurgie, Universität des Saarlandes, Homburg/Saar, Germany Department of Orthopedics, Capio St. Göran's Hospital, Stockholm, Sweden Division VII, Istituti Ortopedici Rizzoli, Italy Institute of Economic Informatics, Warsaw University of Life Sciences, Warsaw, Poland Nuffield Orthopaedic Centre, Oxford, UK Department of Obstetrics and Gynecology, Akershus University Hospital, Lørenskog, Norway Department of Endocrinology, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Go¨teborg, Sweden Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm Department of Medical Sciences, Uppsala University, Uppsala, Sweden Discipline of Medical Genetics, Faculty of Health, University of Newcastle, and the Hunter Medical Research Institute, New Lambton Heights, Newcastle, New South Wales, Australia Department of Endocrinology, Centre for Postgraduate Medical Education, Bielanski Hospital, Warsaw, Poland Cell Signalling Unit, Children's Medical Research Institute, Westmead, New South Wales, Australia Division of Genetics, Hunter Area Pathology Service, John Hunter Hospital, Australia Department of Orthopaedic Surgery, Sint Maartenskliniek, The Netherlands Division of Orthopedics, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden Department of Orthopaedic Surgery, University of California, San Francisco, CA, USA Department of Orthopaedics, Institute of Surgical Sciences, Sahlgrenska University Hospital, Gothenburg, Sweden Department of Orthopaedic Surgery, University of California, San Francisco, CA, USA Orthopaedic Biomechanics Laboratory, Midwest Orthopaedic and Minneapolis Medical Research Foundations, Minneapolis, MN, USA Behavioural Biology, Centre for Behaviour and Neuroscience, University of Groningen, Groningen, The Netherlands Centre for Ecology and Conservation, College of Life and Environmental Sciences, University of Exeter Spine Unit, Department of Orthopaedics E, Aarhus University Hospital, Aarhus, Denmark Hospital for Children and Adolescents, HUS, Finland Laboratory of Biomechanics and Biomaterials, Department of Orthopedic Surgery, Hannover Medical School, Hannover, Germany Department of Public Health, Osaka City University Graduate School of Medicine Department of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany Department of Orthopedics, AIM/IKE, Faculty of Health Science, Linköping University, Linköping, Sweden The Swedish Hip Arthroplasty Register. Department of Orthopaedics, Institute of Surgical Sciences, Sahlgrenska University Hospital, University of Gothenburg, Mölndal, Sweden Department of Orthopaedic Surgery and Clinical Institute, Odense University Hospital, Odense, Denmark Department of Machinery, Industrial Research Institute of Ishikawa, Ishikawa, Japan Department of Biology, University of Louisiana-Lafayette, Lafayette, LA 70504, USA Department of Orthopaedic Surgery, Hvidovre University Hospital, Copenhagen, Denmark Department of Orthopaedic Surgery, Hvidovre University Hospital, Copenhagen, Denmark Preclinical Imaging Facility, Cornell University, Ithaca, NY, USA Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA, USA Department of Orthopaedic Surgery, University of Michigan, USA Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, NRB7, Boston, MA 02115 Department of Orthopaedics, Aarhus University Hospital, Aarhus, Denmark Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK Hôpital Pitié Salpétrière, Paris, France Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA Department of Traumatology and Orthopedic Surgery, Ludwig-Maximilians-University, Munich, Germany AO Research Institute, AO Foundation, Davos, Switzerland Department of Trauma Surgery, University Hospital, Essen, Germany Division of Orthopedics, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden Section of Radiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden Hospital for Children and Adolescents, Helsinki University Central Hospital Department of Orthopedic Surgery, Akershus University Hospital, Oslo, Norway Dianthus Medical Limited, 4 Lyon Road, London SW19 2RL, UK Department of Anaesthesia and Pain Clinic, Ghent University Hospital, De Pintelaan 185, Ghent 9000, Belgium Department of Orthopedic Surgery, First Affiliated Hospital, Fujian Medical University, Fuzhou, China Department of Cell and Developmental Biology, University of Pennsylvania, USA Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA Department of Human Genetics, University of Utah, Salt Lake City, UT 84132, USA Department of Orthopedic Surgery, School of Medicine, University of Thessalia, Larissa, Greece Department of Reproductive Biology, Instituto Nacional de Ciencias Me´dicas y de la Nutricio´n Salvador Zubira´n, Mexico City, Mexico Center for Translational Genetics, Rappaport Institute for Research in the Medical Sciences, Israel Institute of Technology, Haifa Bruce Rappaport Faculty of Medicine, Haifa Department of Orthopaedics, Tampere University Hospital, Tampere, Finland The Oncology Unit, Royal Orthopaedic Hospital, Birmingham, UK Institute of Sport Sciences and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark Department of Orthopedics, Clinical Sciences, Lund University, Lund, Sweden Department of Surgical Sciences, University of Bergen, Bergen, Norway Department of Health, University Research Bergen, Bergen, Norway Department of Orthopaedic Surgery, Rikshospitalet University Hospital, and Faculty of Medicine, University of Oslo, Oslo, Norway Patient Insurance Center, Helsinki, Finland Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China Department of Epidemiology, Italian National Cancer Institute Regina Elena, Italy Division of Orthopedic Surgery, McMaster University, Ontario, Canada School of Marine Biosciences, Kitasato University, Ofunato, Iwate 022-0101, Japan Division of Fishes, National Museum of Natural History, Smithsonian Institution, Washington, DC 20560, USA Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford OX3 7JX Mathematical Ecology Research Group, Department of Zoology, University of Oxford, Oxford OX1 3PS, UK VINCA - Vienna Institute for Nature Conservation & Analyses, Giessergasse 6/7, 1090 Vienna, Austria Institute of Botany, Department of Integrative Biology, University of Natural Resources and Applied Life Sciences (Boku), Gregor-Mendel-Str. 33, 1180 Vienna, Austria Institut Pasteur, Unité de Biologie et Génétique du Paludisme, 28 rue du Dr Roux, Paris cedex 15, Paris 75724, France Department of Microbiology & Immunology, College of Physicians and Surgeons, Columbia University, Room 1502, Hammer HSC, 701 W. 168th Street, New York, NY 10032 Department of Infectious Diseases, University Hospital of Bern, Switzerland Department of Anesthesiology, Children's Hospital of Eastern Ontario, University of Ottawa, Canada Department of Anaesthesiology, Kantonsspital Liestal, University of Basel, Rheinstrasse 26, 4410 Liestal, Switzerland Wilson Centre for Education Research and 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Biology, Baylor College of Medicine, Houston, TX 77030, USA Department of Physiology, Institute of Biomedicine, University of Turku, Finland Department of Medical Biochemistry and Biophysics, Umea˚ University, Umea˚ SE-901 87, Sweden Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Health Sciences Center, Louisville, KY 40202, USA Department of Reproductive Biology, Imperial College London, Hammersmith Campus, London W12 0NN, UK MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital Box 285, Cambridge CB2 0QQ, UK Department of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences, PO Box 5003, 1432 Aas, Norway Avon Orthopaedic Centre, Southmead Hospital, Bristol, UK Hasselt University, Diepenbeek, Belgium Canisius Wilhelmina Hospital, Nijmegen Bayer Healthcare, Montville, NJ, USA Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands University Hospital 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Netherlands Department of Orthopaedic Surgery, Medical University Innsbruck, Innsbruck, Austria Department of Orhopedics, Uppsala University Hospital, Uppsala, Sweden Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX3 1QZ, UK Institute of Biomedical Technology (BMTI) and Department of Polymer Chemistry and Biomaterials, University of Twente, Enschede, the Netherlands Department of Biochemistry and Molecular Biology and Department of Orthopaedics, University of Medicine and Dentistry of New Jersey, New Jersey Medical School and Graduate School of Biomedical Sciences, Newark, NJ, USA Department of Clinical Pathophysiology, University of Turin, Turin, Italy Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus, Denmark Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan Department of Biostatistics, University of Turku, Turku, Finland Perth Royal 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Site, Robinson Way, Cambridge CB2 0SR, UK MRC Biostatistics Unit, Institute of Public Health, UK Department of Public Health and Primary Care, Institute of Public Health, Cambridge University, Forvie Site, Robinson Way, Cambridge CB2 0SR, UK School of Physical Education and Sport, University of S˜ao Paulo, SP 05508-900, Brazil Department of Chemical and Systems Biology, Stanford University School of Medicine, CCSR, Rm 3145A, 269 Campus Drive, Stanford, CA 94305-5174, USA University of Pittsburgh Medical Center, Division of Gastroenterology, 200 Lothrop St, Pittsburgh, PA 15213, USA Clermont Universit´e, Universit´e d'Auvergne, BP 10448, F-63000 Clermont-Ferrand, France; Inserm, U 931, F-63001 Clermont-Ferrand, France and CNRS, UMR 6247, F-63001 Clermont-Ferrand, France Department of Agriculture, Ministry of Agriculture and Cooperatives, Rubber Research Institute of Thailand, Chachoengsao, Thailand National Center for Genetic Engineering and Biotechnology, 113 Phaholyothin Rd. , Klong 1, Klong Luang, Pathumthani 12120, Thailand Department of Biotechnology, Faculty of Science, Mahidol University, Phayathai, Bangkok 10400, Thailand Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom 73170, Thailand Department of Internal Medicine I, University of Wu¨rzburg, Wu¨rzburg, Germany Department of Internal Medicine II, St-Elisabeth Hospital, Bad Kissingen, Germany Institute of Pathology, University of Wu¨rzburg, Josef-Schneiderstr. 2, D-97080 Wu¨rzburg, Germany Johnson and Johnson Medical SpA, DePuy Division, Pratica di Mare (RM), Italy Avon Orthopaedic Centre, Southmead Hospital, Bristol, United Kingdom Orthopaedic Research Unit, Department of Orthopaedic Surgery and Traumatology, Turku University Hospital and University of Turku, Turku, Finland Division of Orthopaedic Surgery, University of Manitoba, Winnipeg, Manitoba, Canada Laboratory of Comparative Genomics, Graduate School of Information Science, Nara Institute of Science and Technology, 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Hospital, Malmö, Sweden Uni Health, Uni Research, Bergen, Norway Department of Orthopaedic Surgery, Herlev University Hospital, Herlev The Norwegian Cruciate Ligament Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver V6H 3N1, Canada Island Medical Program, University of Victoria, Victoria V8P 5C2, Canada Department of Medical Genetics, University of British Columbia, Vancouver V6T 1Z3, Canada Recurrent Pregnancy Loss Program, University of Chicago Medical Center, Chicago 60637 Department of Obstetrics and Gynecology, University of Chicago, USA Women's Health Centre of British Columbia Genesis Fertility Centre, Vancouver V5Z 3X7, Canada Moredun Research Institute, United Kingdom Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, United Kingdom INRA, UMR1253 STLO, France Department of Microbiology and Immunology, New York Medical College, Valhalla, 10595 NY, USA Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands Department of Neurosurgery, Department of Cancer Biology and Genetics, and Brain Tumor Center, 1275 York Ave, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA (currently) Uppsala University, Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, SE-751 85 Uppsala, Sweden Karolinska Healthcare Research Biobank (KHRBB), Clinical Pathology/Cytology, Karolinska University Hospital, SE-17176 Stockholm, Sweden Department of Oncology-Pathology, Karolinska Institutet, CCK R8:04, Karolinska University Hospital Solna, SE-17176 Stockholm, Sweden Department of Medical Education, Florida Hospital East Orlando, 7975 Lake Underhill Rd Suite 200, Orlando FL 32822, USA Uppsala University, Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden Department of 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Hospital Malmö, Malmö, Sweden Department of Radiology, Oncology and Radiation Science, Uppsala University, Akademiska Sjukhuset, Uppsala, Sweden Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway The Wistar Institute, Philadelphia, Pennsylvania, USA Department of Immunology, Genetics and Pathology, Uppsala University, SE 751 85 Uppsala Uppsala University, Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden Department of Urology, Kent and Canterbury Hospital, Canterbury, Kent, UK 19 Mayis University Faculty of Medicine - Pulmonary Medicine, Samsun, Turkey Afyon Chest Diseases Hospital - Pulmonary Medicine, Afyonkarahisar St Thomas's Hospital, London, UK Department of Dermatology, Norfolk & Norwich University Hospital, UK General Surgery, City Hospitals Sunderland NHS Foundation Trust, Sunderland Oxford Transplant Centre, Oxford Radcliffe Hospitals NHS Trust, Oxford, UK Plastic & Reconstructive Surgery, John Radcliffe Hospital, Oxford OX1 1JE, UK General Surgery, Worthing and Southlands NHS Trust, Worthing, UK Department of Biology, University of Neuchaˆ tel, Emile-Argand 11, Neuchaˆ tel 2009, Switzerland Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK Life Sciences Institute and Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109-2216, USA Sector for Molecular Evolution, Institute for Information Transmission Problems of the Russian Academy of Sciences (Kharkevich Institute), Bolshoi Karetny pereulok 19, Moscow 127994, Russia Department of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Vorbyevy Gory 1-73, Moscow 119992, Russia Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Queensland 4072, Australia School of Biological Sciences A08, University of Sydney, New South Wales 2006, Australia School of Molecular Medical Sciences, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK Department of Zoology, University of Oxford, Oxford OX1 3PS Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, TX 79430 Harvard Medical School, 25 Shattuck Street, Boston, MA 02115 Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston MA 02115, USA Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA Department of Gastroenterology, Agia Olga Hospital, Agias Olgas 3-5, 142 33, Athens, Greece Institute of Chest Diseases, Kangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Pulmonary Division, Department of Medicine, Kangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Department of Surgical Sciences, University of Uppsala, Uppsala, Sweden Radiology 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Box 80165, 3508 TD, Utrecht, The Netherlands Faculdade de Cieˆncias Farmaceˆuticas de Ribeira˜o Preto, Universidade de Sa˜o Paulo, Av do Cafe´, sn/n, 14040-903, Ribeira˜o Preto, SP, Brazil Institute of Anatomy, Otto-von-Guericke University, Germany Laboratoire de Pharmacologie-Toxicologie, UR 66, Institut National de la Recherche Agronomique, Toulouse, France Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium Vaccine design, Department of Biosystems, K. U. Leuven, Kasteelpark Arenberg 30, B-3001 Heverlee, Belgium Present affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48864, USA Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI 48864, USA Alberta-Pacific Forest Industries Inc. P. O. 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UCL Institute of Ophthalmology, London Addenbrooke's Hospital, Cambridge, UK St George's Hospital, London, UK Department of Ophthalmology, Innland Hospital, Elverum, Norway Department of Medical Genetics, Ulleva˚ l University Hospital, Oslo, Norway Moorfields Eye Hospital, City Road, London, UK West Midlands Regional Genetics Service, Birmingham Women's Hospital, Birmingham, UK Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815-6789, USA Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA Information Management Services, Inc. , Silver Spring, MD, USA Core Genotyping Facility, National Cancer Institute, NIH, Bethesda, MD, USA Marshfield Clinic Research Foundation, Marshfield, WI, USA Institute of Biostatistics, School of Life Science, Fudan University, Shanghai, People's Republic of China Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA Department of Pathology, University of 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and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates Molecular Medicine Section, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK MRC Centre for Developmental Neurobiology, Kings College London, New Hunts House, London SE1 1UL, UK Howard Hughes Medical Institute, Department of Pediatrics, Section of Developmental Biology, University of Colorado Denver School of Medicine, Aurora, CO, USA Clinical Centre of Endocrinology and Gerontology, Medical University, 2 Zdrave St, 1431 Sofia, Bulgaria Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, 4000 Liège Department of Pediatrics, University of Maryland Medical Center, 22 South Greene St. , Baltimore, MD 21201, USA Department of Internal Medicine, Johns Hopkins University/Sinai Hospital, 2401 W. Belvedere Ave. , Baltimore, MD 21215, USA Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2E9 Tuscany Regional Health Agency, I. O. T, Firenze, Italy Laboratory of Clinical Epidemiology, Geriatrics Department, Italian National Research Council on Aging, Florence, Italy Peninsula Medical School, RD&E Wonford Site, Barrack Road, Exeter EX2 5DW Laboratory of Neurogenetics, National Institute of Ageing, Porter Neuroscience, USA Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD, USA Longitudinal Studies Section, Clinical Research Branch, Gerontology Research Center, National Institute on Aging Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy Departamento de Medicina, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Rua João das Botas S/N, Canela, Salvador, BA Fundação Oswaldo Cruz, Centro de Pesquisa Gonçalo Moniz, Rua Waldemar Falcão, Candeal, Salvador, BA, Brazil Newcastle Auditory Group, Medical School, Newcastle University, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK University of Alberta, Edmonton, AB, Canada University of Toronto, Canada Centre for Addiction and Mental Health, Toronto, ON, Canada Veterans Affairs and Stanford University Medical Centers, Stanford, CA, USA Evolution Health Systems Inc. , Toronto, ON, Canada Department of Preclinical Research and Development, CSL Behring GmbH, Marburg, Germany Department of Cardiology, University Hospital Jean Minjoz, EA3920, Boulevard Fleming, 25000 Besanc¸on, France Department of Physiology and Cardiology, Universitair Medisch Centrum Utrecht, Utrecht, The Netherlands Department of Cardiology and Pneumology, University Medical Centre Go¨ ttingen, Georg-August-Universita¨t, Go¨ ttingen, Germany Department of Clinical Pharmacology, University Medical Centre Go¨ ttingen, Go¨ ttingen, Germany Institute for Clinical Research, University Medical Centre Go¨ ttingen, Go¨ ttingen, Germany BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK Department of Cardiovascular Sciences, Division of Clinical Cardiology, University of Leuven, Leuven, Belgium Heart Research Centre Go¨ ttingen, Go¨ ttingen Department of Medical Statistics, Centre for Informatics, Statistics and Epidemiology, University Medical Centre Go¨ ttingen, Germany Department of Medicine, University of Fribourg, Fribourg Psychology and NeuroCognition Laboratory, University Pierre Mendès-France and CNRS, Grenoble, France Department of Human Perception, Cognition and Action, Max Planck Institute for Biological Cybernetics, Tübingen Division of Psychiatry, University of Nottingham, Nottingham NG7 2UH, UK Health care of Older People, Nottingham University Hospitals NHS Trust, Queens Medical Centre, Nottingham NG7 2UH Division of Rehabilitation and Ageing, University of Nottingham, Nottingham NG7 2UH, UK Mental Health Services for Older People, Nottinghamshire Healthcare NHS Trust, Queens Medical Centre, Nottingham NG7 2UH, UK Department of Radiology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands Department of Obstetrics and Gynaecology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic Department of Cardiovascular Medicine, Wellcome Trust Center for Human Genetics, Oxford, UK CNR Institute of Neurosciences, Department of Biomedical Sciences, University of Padova, Viale G. Colombo 3, Padova 35121, Italy Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic University of Tsukuba, Tsukuba and The University of Tokyo, Tokyo, Japan National Research Centre for the Working Environment, Copenhagen, Denmark Epidemiological Research Unit, Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark Division of Pulmonary and Critical Care Medicine, Keck School of Medicine of USC, Los Angeles, CA 90033, USA Department of Obstetrics and Gynecology, Duke University, Durham, NC 27710, USA Department of Obstetrics and Gynecology, Virginia Commonwealth University, Center on Health Disparities and Institute for Women's Health, MCV Campus, Sanger Hall, 1st Floor, Room 1-071, 1101 East Marshall Street, PO Box 980565, Richmond, VA 23298, USA Department of Biology, University of Padua Medical School, Padova, Italy Department of Medico-Diagnostic Sciences and Special Therapies, University of Padua Medical School, Padova, Italy Department of Cardiac, Thoracic and Vascular Sciences, University of Padua Medical School, Via Giustiniani 2, 35100 Padova, Italy Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, MN, USA Institute of Cardiology, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy Division of Chest Medicine, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan Department of Internal Medicine, Far Eastern Memorial Hospital, Pan-Chiao, Taipei County, Taiwan Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, 96 Jonathan Lucas St, Suite 812 CSB, Charleston, SC 29425, USA La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan National Institute for Basic Biology, Myodaiji, Okazaki 444-8585 Department of Genetics, Biology Division, Moscow State University, 119899 Moscow, Russia Institute of Plant Physiology, Botanicheskaya Street 35, 127276 Moscow, Russia University of North Carolina at Charlotte, Charlotte, NC 28223, USA National Centre for Genome Resources (NCGR), Santa Fe, NM 87505 Barkatullah University, Bhopal 462 026, India National Research Centre on Plant Biotechnology, India J. Craig Venter Institute (JCVI), Rockville, MD 20850 Purdue University, West Lafayette, IN 47907-2054 United States Department of Agriculture-Agricultural Research Service (USDA-ARS), Corn Insects and Crop Genetics Research Unit, Ames, IA 50011, USA CGIAR Generation Challenge Programme (GCP), c/o CIMMYT, 06600 Mexico DF, Mexico Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsutacho, Midoriku, Yokohama 226-8501, Japan Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan Noda Institute for Scientific Research, 399 Noda, Noda, Chiba 278-0037, Japan Research and Development Division, Kikkoman Corporation, 399 Noda, Noda City, Chiba 278-0037, Japan Division of Population Genetics, National Institute of Genetics, Mishima 411-8540, Japan Department of Genetics, School of Life Science, Graduate University for Advanced Studies, Mishima 411-8540, Japan National Research Institute of Brewing, 3-7-1 Kagamiyama, Higashi-hiroshima, Hiroshima 739-0046, Japan Laboratory of Bioindustrial Informatics, Department of Bioindustrial Informatics and Genomics, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai 981-8555, Japan Laboratory of Bioindustrial Genomics, Department of Bioindustrial Informatics and Genomics, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai 981-8555, Japan Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada T6G 2H9 Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3 Departments of Physical Therapy and Oncology, University of Alberta, Edmonton, Alberta, Canada T6G 2G4 Perinatal Epidemiology Research Unit, Departments of Obstetrics and Gynaecology and Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada B3K 6R8 Departments of Oncology and Community Health Sciences, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N2 Department of Population Health Research, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2 Department of Medicine, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N2 Department of Public Health Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2T4 Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z2 Department of Nephrology, UMC Utrecht, Utrecht, The Netherlands Gambro Research and Development, Sweden Laboratory for Biomechanical Engineering, University of Twente, Enschede, The Netherlands Universitair Ziekenhuis Brussel (UZ Brussel), Department of Orthopaedic Surgery and Traumatology, Brussels, Belgium Radboud University Nijmegen Medical Centre, Orthopaedic Research Laboratory, Nijmegen, the Netherlands Division of Cardiovascular Genetics, Department of Medicine, University College London, 5 University Street, London WC1E 6JF, UK Chromatin Structure and Epigenetic Mechanisms Unit, Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, USA Molecular Biology Institute, University of California Los Angeles Department of General Surgery, Watford General Hospital, Vicarage Road, Watford WD18 0HB, UK Division of Pulmonary and Critical Care Director, Center for Pulmonary Vascular Disease, Duke University Medical Center, Durham, NC 27710, USA Department of Microbiology and Molecular Genetics, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 225 Warren Street, Newark, NJ 07103, USA Royal Brompton and National Heart Hospital, London, UK Avicenne University Hospital, Bobigny and Paris 13 University, Paris, France Department of Clinical Sciences at Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden School of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia (IIT), via Morego 30, 16152 Genova, Italy National Nanotechnology Laboratory (NNL), CNR—Istituto di Nanoscienze, via per Arnesano, 73100 Lecce, Italy Royal Holloway, University of London, School of Biological Sciences, Egham, Surrey TW20 0ZX, UK Aoslbeenrzt-aL, uItdawlyigs-University, Institute for Biology II, Faculty of Biology, University of Freiburg, Schänzlestr. 1, D-79104, Freiburg, Germany Key Laboratory of Horticultural Plant Biology (MOE), Huazhong Agricultural University, Wuhan 430070, PR China Center for Infectious Disease Dynamics, Pennsylvania State University, Pennsylvania, PA 16802, USA MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK Department of Zoology, Oxford University, Oxford, UK Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA Department of Fisheries, Wildlife, and Conservation Biology, University of Minnesota, MN 55108, USA Foodomics lab, Institute of Food Science Research, CIAL-CSIC, Madrid, Spain Dept. BOS, University of Oviedo, Oviedo, Spain Plant Development and Nuclear Architecture lab. Biological Research Center, CIB-CSIC, Madrid Graduate University, Chinese Academy of Sciences, Yuquan Road 19, 100049 Beijing, China Ju¨lich Center for Neutron Science (JCNS-1) and Institute for Complex Systems (ICS-1), Forschungszentrum Ju¨lich, Ju¨lich, Germany CNR-IOM, OGG c/o Institut Laue-Langevin, 6 rue Jules Horowitz, 38042 Grenoble, France Ju¨lich Centre for Neutron Science JCNS, Forschungszentrum Ju¨lich, Germany FH Aachen, Institute for Bioengineering, Heinrich-Mußmann-Straße 1, 52428 Ju¨lich, Germany Laboratoire de Biochimie The´orique-CNRS UPR9080, Institut de Biologie Physico-Chimique, 13, rue Pierre et Marie Curie, 75005 Paris Institut Laue-Langevin and CNRS, 6 rue Jules Horowitz, 38042 Grenoble, France Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM ), 3720 BA Bilthoven, The Netherlands Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Kyoto 332-0012, Japan Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, NIH, Baltimore, MD 21224 Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam, Germany Institute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476 Potsdam Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, NIH, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA School of Biological Sciences, The University of Northern Colorado, Greeley, CO 80639, USA Edward J. Meeman Biological Field Station, The University of Memphis, Millington, TN 38058, USA Department of Biology, Christian Brothers University, Memphis, TN 38104, USA Department of Biology, Western Carolina University, Cullowhee, NC 28723, USA Nuffield Department of Clinical Medicine, Oxford University INSERM U897, Bordeaux, France NIML, Montreal, Canada AP-HP, Hôpital H. Mondor-A. Chenevier, Service Hospitalier, Créteil, France McGill University Health Center, Montreal, Canada San Raffaele Scientific Institute, Milan, Italy Hosp St-Louis, Paris, France CVPath Institute, Inc. , Gaithersburg, MD, USA OrbusNeich, Fort Lauderdale, FL, USA Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands Medical Faculty, Masaryk University and University Hospital Brno, Czech Republic Cardiology Department, Third Faculty of Medicine, Charles University Prague, University Hospital Kralovske Vinohrady, Srobarova 50, Prague 10, Czech Republic First Faculty of Medicine, Charles University Prague, Czech Republic University Hospital St Anne, Brno, Czech Republic Bulgarian Cardiology Institute, Pleven, Bulgaria Faculty of Medicine Plzen, Charles University Prague, Czech Republic National Institute of Public Health, Prague, Czech Republic Research Centre for Health Promotion, Faculty of Psychology, University of Bergen, Bergen, Norway Department of Transplantation and Clinical Immunology, University of Lyon-1 and Edouard Herriot Hospital, Lyon, France Laboratory of Dermatological Research, University of Lyon-1 EA 41-69, Building R, Edouard Herriot Hospital, 69437 Lyon Cx 03, France Institute of Macromolecular Chemistry Petru Poni, Romania Faculty of Life Sciences, University of Manchester, UK Department of Histopathology, Eastbourne District General Hospital, Eastbourne, UK Department of Radiology, Eastbourne District General Hospital, Eastbourne, UK Department of ENT, Salisbury District Hospital, Salisbury SP2 8BJ, UK Department of Medicine, Harbor-University of California, Los Angeles, California, USA Department of Diabetes and Endocrinology, King's College London School of Medicine, London, UK Department of Nephrology, University Hospital of North Staffordshire, Stoke-on-Trent, Staffordshire, UK Department of Nephrology, Lund University, University Hospital of Malmo¨, Malmo¨, Sweden Department of Orthopaedics, Institute of Surgical Science, Sahlgrenska University Hospital, Göteborg University, Mölndal, Sweden The Swedish Hip Arthroplasty Register, Department of Orthopaedics, Institute of Surgical Sciences, Sahlgrenska University Hospital, University of Gothenburg, Mölndal, Sweden Department of Orthopaedic Surgery and Traumatology and Clinical Institute, Odense University Hospital, Odense, Denmark Department of Orthopaedics, Institute of Surgical Science, Sahlgrenska University Hospital, Göteborg University, Mölndal, Sweden Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala Department of Orthopaedics, Institute of Clinical Sciences at Sahlgrenska Academy, Gothenburg University Department of Molecular Medicine and Surgery, Section of Orthopaedics and Sports Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden. Department of Molecular Medicine and Surgery, Section of Radiology, Karolinska University Hospital, Karolinska Institutet, Stockholm Department of Physiological Science, University of California Los Angeles (UCLA), 3836 Life Sciences Building, Los Angeles, CA 90095, USA Department of Physiology and Biophysics, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, USA Center for Medical Imaging and Physiology, Lund University and Skåne University Hospital, Lund, Sweden Institute for Rare Diseases and Department of Orthopaedic Surgery, Korea University Medical Center, Guro Hospital, Seoul, South Korea Department of Medical Genetics, University of Calgary, Room 287, Heritage Medical Research Building, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1 Department of Orthopaedic Surgery, St. Mary's Hospital, London Department of Orthopaedic Surgery, University Paris Descartes, European Hospital Georges Pompidou, APHP, Paris, France Department of Radiology, University Paris Descartes, European Hospital Georges Pompidou, APHP, Paris, France Division of Surgery and Cancer, Imperial College London School of Medicine, London, UK Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States Departments of 1Trauma, Hand and Reconstructive Surgery and 2Gastroenterology, Section of Endocrinology, and 3Institutes of Anatomy and Cell Biology, University Hospital Giessen and Marburg, Marburg; 4Department of Pathology, Bonn University Hospital, Bonn, Germany Division of Orthopedic Surgery, Department of Surgery, University Hospitals of Geneva, and Faculty of Medicine, Geneva Bioinformatics Research Unit, Division of Genome and Biodiversity Research, National Institute of Agrobiological Sciences, 2-1-2 Kannondai, Tsukuba, Ibaraki 305-8602, Japan Bioinformatics Centre, Bose Institute, P 1/12, C. I. T. Scheme VII M, Kolkata 700 054, India Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK Laboratory of Cell Engineering, Department of Human Genome Research, Kazusa DNA Research Institute, Kisarazu, Chiba 292-0818, Japan Laboratory of Molecular Pharmacology, National Cancer Institute, NIH, Bethesda, MD 20892, USA Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University, Nishi-cho, Yonago, Tottori, Japan RIKEN Plant Science Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan Department of Mathematics & Statistics, Open University, Milton Keynes, United Kingdom Central Institute for Medical and Chemical Laboratory Diagnostics, Innsbruck Medical University, Innsbruck, Austria Institute of Pharmacy/Pharmacognosy, University of Innsbruck, Josef-Moeller-Haus, Innrain 52c, A-6020 Innsbruck, Austria Head of the Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Innsbruck Medical University, Innrain 66, A-6020 Innsbruck Department of Pharmacy, Center of Drug Research, University of Munich, 81377 Munich Department of Pharmacognosy, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland National Institute for Health Research Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom Department of Cardiology, Ska˚ne University Hospital, Lund University, Lund Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Department of Clinical Physiology, Ska˚ne University Hospital, Lund University, Lund SE-22185 Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, 171 76 Stockholm, Sweden Faculty of Veterinary Medicine, Institute of Virology, Justus-Liebig-University, Giessen, Germany De´partment de Virologie, Institut Pasteur, Unite´ de Virologie Structurale, CNRS URA 3015, Paris, France Department of Urology, University of California San Francisco, San Francisco, CA 94143-1695, USA Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611-4402, USA Department of Medical Genetics, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada T2 N 4N1 Department of Obstetrics and Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143-1695, USA Renal Medicine, Department of Medical Sciences, Uppsala University Hospital, Akademiska sjukhuset, 75185 Uppsala, Sweden Department of Immunology, Genetics and Pathology, Uppsala University, The Rudbeck Laboratory, 75185 Uppsala, Sweden Program in Behavioral and Cognitive Neuroscience, Department of Psychology, University of Iowa, Iowa City, Iowa, United States of America Department of Anaesthesia and Intensive Care, Government Medical College, Srinagar, Jammu and Kashmir, India Department of Neurosurgery, Tokuda Hospital, Sofia, Bulgaria Department of Internal Medicine, University of Kuopio, Kuopio, Finland Gentofte University Hospital, Copenhagen, Denmark Medtronic Bakken Research Center, The Netherlands Department of Internal Medicine, University of Oulu, PO Box 5000 (Kajaanintie 50), 90014 Oulu, Finland Glostrup Hospital, Copenhagen Department of Internal Medicine, Pa¨ija¨t-Ha¨me Central Hospital, Lahti, Finland Department of Internal Medicine, Hopital Citadelle, Liege, Belgium Department of Cardiology, University of Tampere, Finland Department of Cardiology, Center for Arrhythmias, Ulleva˚l University Hospital, Oslo St Antonious Hospital, Nieuwegein, The Netherlands Department of Applied Chemistry, Faculty of Engineering, Kogakuin University, 1-24-2 Nishi-Shinjuku, Shinjuku-ku, Tokyo 163-8677, Japan Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwashi, Chiba 277-8562, Japan Institute of Child Health, University College, London, UK Department of Public Health, University of Helsinki, Helsinki Department of Orthopaedics, Institute of Surgical Science, Sahlgrenska University Hospital, Gothenburg University, Mölndal, Sweden Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark Department of Orthopaedics and Traumatology, Turku University Hospital, Turku Fondazione Policlinico S. Matteo IRCCS, Pavia, Italy IRCCS Istituto Clinico Humanitas, Rozzano (Milan), Italy Institute of Cardiology, University of Bologna, Azienda Ospedaliera S. Orsola-Malpighi, Via Massarenti 9, 40138 Bologna, Italy Sacro Cuore Hospital, don Calabria, Negrar, Verona, Italy University of Florence, Florence, Italy S. Filippo Neri Hospital, Rome, Italy Niguarda Hospital, Milan, Italy Medtronic Italia, Rome, Italy S. Anna Hospital, Como, Italy Infectious Diseases Network for Treatment and Research in Africa, Kampala, Uganda Department of Pharmacology and Therapeutics, Trinity College, Dublin, Ireland Infectious Diseases Institute, Makerere University, Uganda Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, Amsterdam Department of Pharmacy & Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand University of Liverpool, Liverpool, UK Institut Universitaire de France, 103 Bd Saint Michel, Paris, France IUT de Schiltigheim, 1 Alle´e d'Athe`nes, 67300 Schiltigheim, France University of Strasbourg, EA4438, Institute of Parasitology Child & Family Research Institute, 950 w. 28th Ave, Room 2082, Vancouver, BC, Canada V5Z 4H4 Department of Medical Genetics, University of British Columbia, Canada Section for Orthopedic Surgery, Department of Surgical Sciences, University of Bergen, Bergen, Norway University of Glasgow School of Medicine, Wolfson Medical School Building, University Avenue, Glasgow G12 8QQ, UK MRC Centre of Epidemiology for Child Health, University College London Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK Africa Centre for Health and Population Studies, University of KwaZulu-Natal, South Africa Center for Reproductive Medicine and Andrology, CeRA, University of Mu¨nster, Domagkstr. 11, 48149 Mu¨nster, Germany Stem Cell Biology Unit, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, D-37077 Go¨ ttingen, Germany Ferring Pharmaceuticals A/S, Global Clinical & Non-Clinical R&D, Copenhagen, Denmark UZ Brussel, Laboratory of Clinical Chemistry and Radio-immunology, Vrije Universiteit Brussel (VUB), Brussel, Belgium Center of Arthroplasty, Kyowakai Hospital, Osaka, Japan Department of Hepatology, Postgraduate Institute of Medical Education & Research Triticeae Research Institute, Sichuan Agricultural University, Dujiangyan, Sichuan, 611830, PR China Japan International Research Center for Agricultural Sciences, Ohwashi 1-1, Tsukuba, Ibaraki, 305-8686, Japan Laboratory of Plant Genetics and Evolution, Hokkaido University, Japan University of Missouri-St. Louis, 1 University Boulevard, St Louis, MO 63121, USA Institute of Archaeology, University College London, 31 - 34 Gordon Square, London WC1H 0PY, UK Chinese National Center for Rice Improvement and State Key Laboratory of Rice Biology, China National Rice Research Institute (CNRRI), Hangzhou 310006, China Department of Plant Sciences and Plant Pathology, Montana State University, Bozeman, MT, USA Institute of Crop Science, University of Kassel, D-37213, Witzenhausen, Germany CNR - Institute of Plant Genetics, Via Amendola 165/A, 70126 Bari, Italy Department of Plant Breeding and Genetics, Cornell University, USA National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8642, Japan National Institute of Agrobiological Sciences (NIAS), Tsukuba 305-8602, Japan MRC Human Reproductive Sciences Unit, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK Department of Plant Sciences, Section of Crop and Ecosystem Sciences, UC Davis, 1 Shields Avenue, Davis, CA 95616-8780, USA Dipartimento di Scienze Ambientali, Universita` di Parma, Italy Dipartimento di Scienze degli Alimenti, Universita` Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy Dipartimento di Scienze Agronomiche e Genetica Vegetale Agraria, Universita` di Sassari, Via De Nicola, 07100 Sassari, Italy Department of Biology, Texas A&M University, 3258 TAMU, College Station, TX 77843 Department of Genetics, Texas Biomedical Research Institute, PO Box 760549, San Antonio, TX 78245, USA Department of Sociology and Gerontology, Miami University, Upham 358, Oxford, OH 45056, USA Department of Anthropology, Temple University, 210 Gladfelter Hall, 1115 Polett Walk, Philadelphia, PA 19122, USA Centro de Pesquisas, Rene´ Rachou, FIOCRUZ Minas, Av. Augusto de Lima 1715, Belo Horizonte, Minas Gerais, Brazil University of Ibadan, Ibadan, Oyo State, Nigeria Broad Institute, Cambridge, MA 02142, USA Department of Organismic and Evolutionary Biology, FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA Australian Tropical Crops and Forages Centre, Queensland Department of Primary Industries and Fisheries, Biloela, QLD 4715 Centre for Plant Conservation Genetics, Southern Cross University, PO Box 157, Lismore, NSW 2480, Australia Department of Biology, University of Leicester, Leicester LE1 7RH, UK Agriculture Research Institute, Department of Applied Genomics, Hungarian Academy of Sciences, Brunszvik u2, Martonvasar 2462, Hungary National Institute of Agrobiological Sciences, Kannondai 2 - 1 - 2, Tsukuba 305-8602, Ibaraki, Japan School of Biological Sciences, The University of Reading, Reading, UK Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Germany Unite´ de Re´gulation des Infections Re´trovirales, Institut Pasteur, Paris, France Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute and University of Basel Integrated Therapy for Chronic Kidney Disease, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan Food and Agriculture Organisation of the United Nations, FAO, Infectious Disease Group, Rome, Italy Wetlands International, PO Box 471, 6700 AL Wageningen, The Netherlands EcoHealth Alliance, 460 West 34th Street, New York, NY 10001 SMBS, 1 Place de l'Amiral Courbet, 80100 Abbeville, France Oiseaux Migrateurs du Pale´arctique Occidental, 5 avenue des Chasseurs, 75017 Paris, France CIRAD-BIOS, UMR CIRAD/INRA CMAEE, 34398 Montpellier, France Percy FitzPatrick Institute, University of Cape Town, Rondebosch, Cape Town 7701, South Africa CIRAD-ES, UR AGIRS, 34398 Montpellier, France Office National de la Chasse et de la Faune Sauvage, CNERA Avifaune Migratrice, Le Sambuc, 13200 Arles, France National University of Science and Technology Friedrich-Loeffler-Institut, Insel Riems, Germany ARC-Onderstepoort Veterinary Institute, Private Bag X5, Onderstepoort 0110 OIE/FAO Reference Laboratory for avian influenza and Newcastle disease, Istituto Zooprofilattico Sper. le delle Venezie, Legnaro, Italy Centre National d'Elevage et de Recherches Ve´te´rinaires, BP 167 Nouakchott, Islamic Republic of Mauritania Direction Nationale des Eaux et Foreˆts du Mali, BP 275 Bamako Department of Orthopedic Surgery, Linköping University Hospital, Linköping Department of Neurosurgery, University of New Mexico School of Medicine, Albuquerque, NM 87131-0001, USA Astbury Centre for Structural Molecular Biology, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK Cardiovascular Division, Department of Cardiology, King's College London, James Black Centre, London SE5 9NU Present address: Federal Office for the Environment (FOEN), Waste Management, Chemicals and Biotechnology Division, CH-3003 Berne, Switzerland Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON N6A 5C1 Department of Molecular Biology and Functional Genomics, Stockholm University, SE-10691 Stockholm, Sweden Present address: Institute for Bioengineering of Catalonia (IBEC), Cellular Biotechnology, Scientific Park of Barcelona, Edifici Helix, Baldiri Reixac 15-21, ES-08028 Barcelona, Spain Department of Cardiology, Casilino Policlinic, Italy Department of Cardiology, Cardinal Massaia Hospital, Asti, Italy Department of Cardiology, General Hospital of Conegliano, Via Brigata Bisagno 4, 31015 Conegliano, Treviso, Italy Cardiopulmonary Science Department, Azienda Ospedaliero-Universitaria S. Maria della Misericordia and IRCAB Foundation, Udine, Italy Instituto de Investigacio´ n Biome´dica, A Corun˜a, Spain Division of Cardiovascular Sciences, Centre for Applied Medical Research, Department of Cardiology and Cardiovascular Surgery, University Clinic, University of Navarra, School of Medicine, Spain Insituto de Investigaci o´n Biome´dica de A Corun˜a, Complejo Hospitalario Universitario A Corun˜a, As Xubias 84, 15006 A Corun˜a, Spain Office of Device Evaluation, Center for Devices and Radiological Health, U. S. Food and Drug Administration, 10903 New Hampshire Avenue, WO66-1232, Silver Spring, MD 20993-0002, USA University of Vienna, Wien, Austria Erasmus Medical Centre, The Netherlands Institut Hospitalier Jacques Cartier, 6 avenue du Noyer Lambert, Massy 91300 France OLV Clinic, Aalst, Belgium J. W. Goethe University, Frankfurt, Germany Kings College Hospital, London, UK Hoˆ pital Bichat, Paris, France West-German Heart Center, Essen Hopital Charles Nicole, Rouen, France Center for Cardiovascular Disease Prevention and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA Department of Internal Medicine II - Cardiology, University of Ulm Medical Center, Albert-Einstein-Allee 23, D-89081 Ulm, Germany Departments of Cardiology, Hospital de Fuenlabrada, Fuenlabrada, Spain Departments of Cardiology, Hospital General Universitario Gregorio Maran˜o´ n, Dr Esquerdo, 46, 28007 Madrid, Spain Departments of Cardiology, Hospital Universitario La Paz Departments of Cardiology, Hospital Bellvitge, Hospitalet de Llobregat, Spain Zoophysiology, Department of Bioscience, Aarhus University, Denmark Institute of Zoology, UK Department of Physiology and Biophysics, Dalhousie University, Canada B Department of Biology, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA Department of Life Sciences, Texas A&M University-Corpus Christi, Corpus Christi, TX 78412, USA Sea Mammal Research Unit, Scottish Oceans Institute, University of St Andrews, Fife KY16 8LB Charite´, Universita¨ tsmedizin Berlin, D-13353 Berlin, Germany Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA 95064, USA Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, NO-7491, Norway Institute of Animal Health, University of Las Palmas de Gran Canaria, 35413 Arucas, Las Palmas, Spain Department of Animal Biology, La Laguna University, 38256 Tenerife, Canary Islands, Spain Aquatic Animal Health Program & Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey, TW20 0EX, UK Max-Planck-Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam-Golm, Germany HortResearch, Private Bag 11030, Palmerston North, New Zealand Department of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, UK Division of Clinical Research Centre, Department of Laboratory Medicine, Karolinska Institutet, SE 141 86 Stockholm, Sweden Division of Obstetrics and Gynaecology, Department of Clinical, Science, Technology and Intervention, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden The Ragon Institute of MGH, MIT and Harvard, Boston, MA 02129 Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc. , NCI- Frederick, Frederick MD 21702, USA Division of Immunology, Department of Pathology, University of Cambridge Cambridge CB2 1QP, and CIMR, CB2 0XY Toronto Western Research Institute Canada Transplant Immunology, Liverpool University Hospital and School of Infection and Host Defence, Liverpool University, Liverpool L69 3BX, UK Department of Psychiatry and Behavioral Sciences and Department of Psychology, Center for the Study of Health and Risk Behaviors, University of Washington, Box 351629, Seattle, WA 98195-1525, USA Department of Clinical Alcohol Research, Lund University, Malmo¨ University Hospital, SE-205 02 MALMO¨ Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA Marshfield Clinic Research Foundation, Marshfield, WI, USA BioInformed LLC, Gaithersburg, MD, USA Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland Institute of Biostatistics, School of Life Science, Fudan University, Shanghai, China Information Management Services, Inc. , Silver Spring, MD Core Genotyping Facility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, Napoli 80131, Italy A. O. Monaldi, Seconda Universita` di Napoli, Napoli, Italy Laboratorio di Genetica Medica, Dipartimento di Patologia Generale and CIRM, Seconda Universita` degli Studi di Napoli, Napoli, Italy Department of Surgery, Division of Neurosurgery, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 100, Taiwan Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taiwan Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, 1 Chang-Te Street, Taipei 100 Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 100, Taiwan Department of Laboratory Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 100, Taiwan Laboratory of Food Microbiology and Food Safety, Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan Laboratory of Microbiology, Faculty of Pharmacy, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956- 8603, Japan Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama, Kanagawa 226-0026, Japan Division of Microbiology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kiyotake, Miyazaki 899-1692, Japan Frontier Science Research Center, University of Miyazaki, Japan Department of Neurology, Odense University Hospital, Sdr. 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Com Ltd, Boston, Lincolnshire PE21 9DP, UK Consultant Orthopaedic Surgeon, The Wellington Hospital, London NW8 9LE, UK Healthcare Support Worker, Parkside Surgery, Boston, Lincolnshire PE21 6PF, UK MPH Candidate 2012, Harvard School of Public Health, Boston NIHR In-Practice Fellow, Imperial College, NIHR In-Practice Fellow, Department of Primary Care and Public Health, Reynolds, Building, Charing Cross Campus St Dunstan's Road, London W6 8RP, UK Division of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada Electronic Health Information Laboratory, CHEO Research Institute, Ottawa, ON, Canada Privacy Analytics, Ottawa, ON, Canada CNR-IFC Lecce section, Ecotekne, Via Prov. le per Monteroni, 73100 Lecce, Italy Department of Biological and Environmental Sciences and Technologies (DiSTeBA), Italy Department of Neurosciences - Section of Neurosurgery, University of Bari Medical School, Italy Neurosurgery Operative Unit, V. Fazzi Hospital, 73100 Lecce, Italy Department of Clinical Immunology and Allergology, Sant'Anrea Hospital, Rome, Italy Department of Pathology - Section of Neuropathology, University of Bari Medical School, Bari, Italy Department of General Surgery, Ondokuz Mayis University, Faculty of Medicine, 55139 Samsun, Turkey Department of Internal Medicine, Ondokuz Mayis University, Faculty of Medicine, 55139 Samsun, Turkey Department of Gastroenterology, Ondokuz Mayis University, Faculty of Medicine, 55139 Samsun, Turkey Transplantation Immunology and Nephrology, University Hospital Basel, Switzerland Nephrology and Dialysis Unit, Department of Internal Medicine, University of Pisa, Italy The Nephrology Research Group, L'Hoˆtel-Dieu de Que´bec Research Institution, Department of Medicine, Faculty of Medicine, Laval University, Que´bec, Canada Division of Nephrology, University Hospital of Lausanne, Lausanne, Switzerland Department of Otolaryngology, Shinshu University School of Medicine, 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Thomson Avenue, Cambridge CB3 0FA, UK Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, 5 University St, London WC1E 6JF Centre for Clinical Pharmacology, British Heart Foundation Laboratories at UCL, London WC1E 6JJ, UK Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK Laboratory for Genotyping Development, Center of Genomic Medicine, RIKEN Yokohama Institute, Yokohama City, Japan Department of Medical and Molecular Genetics, King's College London School of Medicine, Guy's Hospital, London SE1 9RT, UK Institute for Digestive Diseases, University College London Hospitals Trust, London NW1 2BU, UK Department of Gastroenterology, Whittington Hospital NHS Trust, London NW11 6BJ, UK Department of Gastroenterology, Guy's & St Thomas' NHS Foundation Trust, St Thomas' Hospital, London SE1 7EH, UK Nutritional Sciences Division, King's College London, Waterloo Campus, London SE1 9NH, UK Department of Gastroenterology and Hepatology, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK Laboratory of Molecular Medicine, Human Genome Centre, Institute of Medical Science, University of Tokyo, Tokyo 108, Japan Centre for Tropical Medicine, Churchill Hospital, University of Oxford, United Kingdom Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Ministério da Saúde, Maputo, Mozambique Health Alliance International, Beira, Mozambique The Graduate University for Advanced Studies (Sokendai), Hayama, Kanagawa 240-0193, Japan The Hygiene Centre, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK ImagoSeine Bioimaging Core Facility, Institut Jacques Monod, 15 rue He´ le` ne Brion, 75205 Paris cedex 13, France ED515 UPMC, 4 place Jussieu, 75005 Paris, France Institut Jacques Monod, CNRS-Universite´ Paris Diderot, Sorbonne Paris Cite´ , 15 rue He´ le` ne Brion, 75205 Paris cedex 13, France Centre for Primary Care Tiel, Dodewaardlaan 509, 4006 EA Tiel, The Netherlands HaCa Foundation, p/a Catharina-ziekenhuis, PO Box 1350, 5602 ZA Eindhoven, The Netherlands Thema Foundation, PO Box 90, 5660 AB Geldrop, The Netherlands Quartz Foundation, PO Box 98, 5700 AB Helmond Departamento de Gene´tica, Instituto Nacional de Sau´de Dr. Ricardo Jorge, 1649-016 Lisboa, Portugal Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina de Lisboa, 1649-028 Lisboa Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, 1649-028 Lisboa, Portugal Unidade Pluridisciplinar de Reproduc¸a˜o Humana, Hospital de Santa Maria, 1649-028 Lisboa, Portugal Instituto de Medicina Preventiva, Faculdade de Medicina de Lisboa, 1649-028 Lisboa, Portugal Departamento de Epidemiologia, Instituto Nacional de Sau´de Dr. Ricardo Jorge, 1649-016 Lisboa, Portugal Department of Medical and Molecular Genetics, King's College London, 8th Floor, Tower Wing, Guy's Hospital, London SE1 9RT, UK Department of Genetics, King Faisal Specialist Hospital and Research Centre Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA Department of Neuropathology, MRC Sudden Death Brain Bank Project, University of Edinburgh, Wilkie Building, Teviot Place, Edinburgh EH8 9AG, UK Department of Biochemistry, Indian Institute of Science, Bangalore, Karnataka 560012, India Department of Genetics, University of Cambridge, Cambridge CB2 3EH Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK Evolutionary Developmental Genomics Group, The Scottish Oceans Institute, University of St Andrews, East Sands, St Andrews KY16 8LB, UK MRC Protein Phosphorylation Unit, College of Life Sciences, James Black Centre, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Trauma and Orthopaedics, Hinchingbrooke Hospital NHS Trust, Hinchingbrooke Park, Huntingdon, PE29 6NS, UK Department of Trauma and Orthopaedics, Royal National Orthopaedic Hospital Trust, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK Department of Trauma and Orthopaedics, Queens Medical Centre, Nottingham University Hospitals NHS Trust, Derby Road, Nottingham, NG7 2UH, UK University Surgical Unit, Colombo South Teaching Hospital, S De S Jayasinghe Road, Kalubowila, 10350, Sri Lanka Department of Anesthesiology, The Second Xiangya Hospital, Central South University; 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Helmholtz Zentrum Mu¨ nchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany Technische Universita¨ t Mu¨ nchen, Center of Life and Food Science, Weihenstephan, Chair of Experimental Genetics, Weihenstephan, Germany Children's National Medical Center, Washington, DC, USA Technische Universita¨ t Mu¨ nchen, Center of Life and Food Science, Weihenstephan, Chair of Developmental Genetics, Weihenstephan, Germany Institute of Developmental Genetics, Helmholtz Zentrum Mu¨ nchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany Department of Informatics, University of Oslo, Blindern, Oslo, Norway Nuffield Department of Clinical Neurosciences (Clinical Neurology), University of Oxford, The West Wing, John Radcliffe Hospital, Oxford, UK Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK Barts and The London School of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK Department of Biological Sciences, Simon Fraser University, USA Department of Clinical and Experimental Medicine, University of Sassari, Italy Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK London School of Hygiene and Tropical Medicine, London, UK Evgenidion University Hospital Department of Nurse Anaesthesiology, National and Kapodistrian University of Athens, Faculty of Nursing, Athens, Greece Department of Anaesthesiology, West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK Department of Neuroradiology, West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK Shanghai Pediatric Congenital Heart Disease Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200092 Institute of Genetics and Biophysics, National Research Council, 80131 Naples, Italy University of Naples Federico II, 80143 Naples, Italy University of Naples Parthenope, 80133 Naples, Italy Baylor College of Medicine, USA Departments of Clinical Biochemistry and Medicine, Cambridge Institute for Medical Research, Addenbrooke's Hospital, UK Endocrine Unit, Queen's Medical Research Institute, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK Biothe´ rapies des Maladies Neuromusculaires Unite´ Mixte: Um76 UPMC, UMR 7215 CNRS, U974, Inserm, Institut de Myologie, Faculte´ de Me´ decine Pierre et Marie Curie, Paris, France MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukie, WI, USA Department of Pediatrics, Medical College of Wisconsin, Milwaukie, WI Neuroscience Program, The Medical College of Georgia, 1120 15th Street Augusta, GA, USA Columbia Fertility Associates Department of Cardiology and Pulmonary Medicine, Georg-August-University Göttingen, Faculty of Medicine, Robert-Koch-Str. 40, 37075 Göttingen, Germany Department of Neuroradiology, Georg-August-University Göttingen, Faculty of Medicine, Robert-Koch-Str. 40, 37075 Göttingen, Germany Department of Neurology, Georg-August-University Göttingen, Faculty of Medicine, Waldweg 33, 37073 Göttingen, Germany Department of Medical Psychology and Medical Sociology, Georg-August-University Göttingen, Faculty of Medicine, Waldweg 37A, 37073 Göttingen, Germany Unita' Operativa di Nefrologia e Dialisi, Ospedali Riuniti di Bergamo, Bergamo, Italy F. Hoffmann-La Roche Ltd, Basel, Switzerland Service de Nephrologie, Hoˆpital Lapeyronie, Montpellier, France Divisione di Nefrologia e Dialisi, Fondazione 'S. Maugeri' IRCCS, Pavia, Italy Divisione di Nefrologia e Dialisi, Azienda Ospedale di Lecco, Lecco, Italy Department of Nephrology, Monash Medical Centre, Clayton, Australia Hospital Reina Sofia, Servicio de Nefrologia, Spain University of Alberta Hospital, Edmonton, Canada Department of Nephrology, Dialysis and Hypertension, O. L. Vrouw Ziekenhuis, Aalst, Belgium School of Medicine, Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK Peninsula Medical School, Institute of Biomedical and Clinical Sciences, John Bull Building, Plymouth, Devon PL6 8BU, UK Department of Orthopaedics and Traumatology, Peijas, Helsinki University Central Hospital, Finland Institute of Surgical Sciences, University of Bergen, Bergen, Norway Department of Orthopaedic Surgery, Trondheim University Hospital, Trondheim Department of Orthopaedic Surgery, Haukeland University Hospital Department of Surgical Science, University of Bergen, Bergen, Norway Department of Radiology, Haukeland University Hospital, Bergen Department of Neuroscience, Norwegian University of Science and Technology, Trondheim Department of Orthopedics, Erasmus Medical Center, Rotterdam Department of Orthopaedics, Hospital Rijnstate, Arnhem, the Netherlands Dipartimento Scienze Cliniche Veterinarie, Facolta' di Medicina Veterinaria, Universita' degli Studi di Milano, Italy Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata-IRCCS, Via dei Monti di Creta, 104, 00167 Rome, Italy Laboratorio di Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan Dipartimento di Chirurgia Cardiaca e Vascolare, Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy Banca Tessuti Cardiovascolari Regione Lombardia, Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy Centro di Statistica, I. N. R. C. A. , Ancona, Italy Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu, China Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, 48 East Wenhui Road, Yangzhou, Jiangsu 225009, China Department of Orthopedics, Viborg Regional Hospital, Viborg Department of Orthopedics, Aarhus University Hospital, Aarhus Department of Orthopedics, Holstebro Regional Hospital, Hostebro Department of Orthopedics, Randers Regional Hospital, Randers Department of Orthopedics, Horsens Regional Hospital, Horsens Department of Dermatology, University Hospital Schleswig-Holstein, University of Lübeck, Lübeck, Germany Department of Hand and Plastic Surgery, Second Affiliated Hospital, Wenzhou Medical College, Wenzhou, People's Republic of China Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany Department of Orthopaedic Surgery, Lillebaelt Hospital, Kolding Spine Section, Department of Orthopaedic Surgery, Lillebaelt Hospital, Middelfart Odense Patient Data Explorative Network (OPEN), Odense University Hospital and Institute of Regional Health Services Research, University of Southern Denmark, Odense Department of Pediatric and Adolescent Surgery, Medical University of Graz, Graz, Austria Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Denmark Department of Small Animal Clinical Sciences, Faculty of Life Sciences (LIFE), University of Copenhagen, Denmark Metabolic Disorders, Amgen Inc. , Thousand Oaks, CA, USA Department of Applied physics, University of Eastern Finland, Kuopio, Finland Orthopaedics Division, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linköping University, Linköping, Sweden The Norwegian Arthroplasty Register, Department of Ortho- pedic Surgery, Haukeland University Hospital; Bergen Department of OrthopedicsUniversity Hospital of Skåne, Lund, Sweden National and OIE/FAO Bovine Tuberculosis Reference Laboratories, Bacterial Zoonoses Unit - Animal Diseases and Zoonoses Research Laboratory, French Food Safety Agency, 23 avenue du Ge´ne´ral-de-Gaulle, 94706 Maisons-Alfort Cedex, France Research Unit in Epidemiology and Risk Analysis applied to Veterinary Sciences, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Lie`ge, B42, Boulevard de Colonster 20, 4000 Lie`ge - Sart Tilman, Belgium Dalarna University, School of Health and Social Studies, Falun, Sweden Centre for Clinical Research, Sweden Linköping University, Medical and Health Sciences, Linköping, Sweden Botany Department, Rhodes University, PO Box 94, Grahamstown 6140, South Africa Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK Department of Anesthesiology, Hvidovre University Hospital, Copenhagen The Lundbeck Centre for Fast-track Hip and Knee Arthroplasty, Hvidovre University Hospital and Rigshospitalet, Copenhagen University, Denmark Wallenberg Laboratory, Sahlgrenska University Hospital, Go¨ teborg, Sweden Department of Psychosomatic Medicine and Psychotherapy, Go¨ ttingen University Medical Center, Go¨ ttingen, Germany Department of Cardiology, Applied Cachexia Research, Charite´-Universita¨tsmedizin, Berlin, Germany Clinical Trial Center, University of Leipzig, Leipzig, Germany Department of Cardiology, Nisˇ, Clinical Center Nisˇ, Serbia Department of Internal Medicine—Cardiology, Charite´-Universita¨tsmedizin, Competence Network Heart Failure, Campus Virchow-Klinkum, Augustenburger Platz 1, 13353 Berlin, Germany Center for Stroke Research, Charite´-Universita¨tsmedizin, Campus Virchow-Klinkum, Berlin, Germany Department of Cardiology, University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia Institute for Cardiovascular Diseases, Sremska Kamenica, Serbia Department of Cardiology, University Clinical Hospital 'Bezˇanijska Kosa', Belgrade, Serbia Department of Cardiology, Clinical Hospital Center Zemun, Faculty of Medicine, University of Belgrade, Belgrade Institute for Experimental and Clinical Pharmacology, University Medical Center Hamburg Eppendorf, Hamburg, Germany Department of Cardiology and Pneumology, Go¨ ttingen University Medical Center, Go¨ ttingen, Germany King's College London Cardiothoracic Department, Guys and St Thomas' Hospital NHS Foundation Trust, London, UK St Jude Medical, Ja¨rfa¨lla, Sweden Uppsala University, Uppsala, Sweden St Thomas' Hospital, London, UK Department of Pediatrics, Aghia Sophia Children's Hospital, University of Athens, Athens, 115 Greece Department of Metabolic Medicine, Royal Hospital for Sick Children, NHS Greater Glasgow and Clyde, Glasgow, UK Children's University Hospital, Dublin, 1 Ireland Department of Endocrinology, Our Lady's Childrens Hospital, Dublin, 12 Ireland Department of Endocrinology, Bakirkoy Maternity and Child Hospital, Istanbul, 34142 Turkey Department of Endocrinology, Royal Manchester Children's Hospital, Central Manchester and Manchester Children's University Hospitals NHS Trust, Manchester, M13 9WL, UK Department of Biochemistry, University of California, San Francisco, CA 94158-2200, USA Institute for Molecular Bioscience and Australian Research Council Centre of Excellence in Bioinformatics, The University of Queensland, Brisbane, Queensland 4072, Australia Department of Medicine and Radiology, Stanford University School of Medicine, Stanford University, Palo Alto, CA 94305 Centro de Investigacio´ n Principe Felipe and Instituto Valenciano de Infertilidad (IVI), Valencia University, Spain Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, SE-171 86 Stockholm Institute of Bioinformation, Chongqing University of Posts and Telecommunications, Chongqing 400065, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 101300, China Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 101300 James D. Watson Institute of Genome Science, Zhejiang University, Hangzhou 310008 Department of Agronomy, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310029, China Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China Department of Cell Biology, Harvard Medical School, Boston, USA Pathology Department, University of Massachusetts Medical School, Worcester, USA Department of Pediatrics and Cardiovascular Research Institute, Gladstone Institute for Cardiovascular Disease, University of California, 1650 Owens Street, San Francisco, CA 94158, USA Division of Developmental Genetics, Institute of Human Genetics , University of Heidelberg, INF 366, 69120 Heidelberg, Germany Mammalian Genetics Unit, Medical Research Council, Harwell, Oxfordshire OX 11 0 RD, UK University of Manchester and Royal Manchester Children's Hospital, UK Institute of Anatomy, University of Wu¨rzburg, Wu¨rzburg, Germany Institute of Pharmacology, University of Wu¨rzburg, Wu¨rzburg, Germany Institute of Physiology, University of Wu¨rzburg, Wu¨rzburg, Germany Heart Center Dresden, Department of Cardiology, University Hospital, Technical University Dresden, Germany Faculty of Life Sciences, University of Manchester, AV Hill Building, Manchester, M13 9PT, UK Department of General and Gastrointestinal Surgery, Hospital San Juan de Dios, Seville, Spain Department of General and Gastrointestinal Surgery, Hospital Universitario de Valme, Seville, Spain Department of Pathology, Medizinische Hochschule Hannover, FRG, Germany Experimental and Surgical Oncology, University of Halle-Wittenberg, FRG, Halle, Germany Oxford Centre for Clinical Magnetic Resonance Research (OCMR), John Radcliffe Hospital, Oxford, UK University Department of Psychiatry, Warneford Hospital, Oxford, UK Neural Information Processing System, University of Ulm, Ulm, Germany Clinic of Internal Medicine II, University Hospital Ulm, Albert-Einstein-Allee 23, 89081 Ulm, 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University, 1-7 Taishido, Setagaya-ku, Tokyo 154-8533, Japan NeurogesX, Inc. , 2215 Bridgepointe Parkway, Suite 200, San Mateo, CA 94404, USA Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, UK Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK Department of Biology and Environmental Sciences, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA ETH Zurich, Institute of Microbiology, Wolfgang-Pauli Strasse 10, 8093 Zu¨ rich, Switzerland The Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, South Parks Road, Oxford, UK Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA Division of Reproductive Endocrinology and Infertility, Department of Obstetrics Gynecology and Reproductive Science, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08901, USA Reproductive Medicine Associates of New Jersey, Morristown, NJ 07960, USA Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA Division of Reproductive Endocrinology and Infertility, Department of Obstetrics Gynecology and Reproductive Science, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick NJ 08901, USA Reproductive Medicine Associates of New Jersey Dipartimento di Fisiologia Umana, Universita` degli Studi di Milano, 20133 Milan, Italy Institute of Gynecology and Obstetrics, The Third Affiliated Hospital of Guangzhou Medical College, Duobao Road, Guangzhou, People's Republic of China Environmental Health Department, Hebron Public Health Directorate, Ministry of Health, Occupied Palestinian Territory Faculty of Science and Technology, Occupational Epidemiology and Biological Research Lab, Hebron University, PO Box 40, Hebron, Occupied Palestinian Territory Department of General Practice and Community Medicine, Faculty of Medicine, Institute of Health and Society, University of Oslo, Section for Preventive Medicine and Epidemiology, PO Box 1130, Blindern, 0318 Oslo, Norway Department of Occupational Medicine and Epidemiology, National Institute of Occupational Health, Oslo, Norway Tibet University Medical College, Lhasa, Tibet, People's Republic of China Finnish Institute of Occupational Health, Centre of Expertise for Health and Work Ability, Topeliuksenkatu 41 aA, FI-00250 Helsinki, Finland UZ Brussel, Centre for Reproductive Medicine, Brussels, Belgium Department of Obstetrics & Gynaecology, Leeds General Infirmary, Leeds, UK The Fertility Clinic, Section 4071, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark Oregon Stem Cell Center, Oregon Health and Science University, Beaverton, OR 97006, USA Leibniz-Institute of Vegetable and Ornamental Crops, Theodor-Echtermeyer-Weg 1, 14979 Grossbeeren, Germany Max-Planck Institute of Molecular Plant Physiology, Germany Departments of Medicine and Cell Biology, Yale University, New Haven CT 06511, USA Departments of Cell Biology and Biomedical Engineering, University of Virginia, USA Department of Microbiology and Cardiovascular Research Center, University of Virginia, Charlottesville VA 22908, USA Department of Psychiatry, Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8 Department of Molecular Biomedical Research, Flemish Institute of Biotechnology, VIB, Ghent Department of Pulmonary Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands Laboratory of Immunoregulation and Mucosal Immunology, Department of Respiratory Diseases, University Hospital, Ghent, Belgium Department of Psychology, University of Montreal, Quebec, Canada H 3 C 3 J 7 Centre for Mental Health Research and Education, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 INSERM U955; 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QZ, UK Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford, UK Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK CIBIO, University of Porto, Campus Agra´ rio de Vaira˜ o, Vaira˜o, Portugal Department of Zoology, Faculty of Science, Charles University in Prague, Prague, Czech Republic Department of Population Biology, Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic, Brno and Studenec, Czech Republic Department of Ecology and Evolutionary Biology and Museum of Zoology, University of Michigan, Ann Arbor, MI, USA Department for Environmental Radioactivity, Norwegian Radiation Protection Authority, Framcenter, Tromsø Laboratory of Mammalian Evolutionary Genetics, Institute of Animal Physiology and Genetics, ASCR, Brno, Czech Republic Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK Center for Neural Science, New York University, 4 Washington Place, NY 10003, USA Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK Centre for Infectious Diseases, University of Edinburgh, Ashworth Laboratories, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK Department of Zoology, University of Oxford, The Tinbergen Building, South Parks Road, Oxford OX1 3PS, UK School of Molecular Medical Sciences, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA Woodrow Wilson School of Public and International Affairs, Princeton University, USA Departamento de Biologia Molecular e Biotecnologia - Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gon¸calves 9500, C. P. 15005, CEP 91501-970, Porto Alegre, RS, Brazil Centro de Biotecnologia, Programa de Po´s-gradua¸ca˜o em Biologia Celular e Molecular, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gon¸calves 9500, C. P. 15005, CEP 91501-970, Porto Alegre, RS, Brazil Graduate University of the Chinese Academy of Sciences, Beijing 100039 The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072 Kroto Research Institute, University of Sheffield, North Campus, Sheffield S3 7HQ, UK Department of Animal and Plant Sciences, University of Sheffield, UK School of Life Sciences, Tsinghua University, Beijing 10084, China Department of Biological Sciences and Biotechnology, Zhangzhou Normal University, 36 Xian Qian Zhi Street, Zhangzhou 363000, Fujian, China Bioinformatics Laboratory, Faculty of Agriculture, Meiji University, Japan Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, 8008 Zurich, Switzerland Genome Biology Laboratory, National Institute of Genetics, Mishima 411-8540, Japan Kihara Institute for Biological Research, Yokohama City University, Maioka-cho 641-12, Yokohama 244-0813, Japan Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China College of Life Science, Shenzhen University, Shenzhen 518060, China Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Newark, NJ McGill University Health Centre, Reproductive Centre, Department of Obstetrics and Gynecology, McGill University, Montreal, Canada Cardiff Fertility Studies Research Group, School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff Wales CF10 3AT, UK Department of Integrative Biology and Evolution, Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna, Savoyenstrasse 1, 1160 Vienna, Austria PRESTO, Yamanaka iPS Cell Special Project, Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan Center for iPS Cell Research and Application (CiRA), Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan Stowers Medical Institute and Harvard Stem Cell Institute, Harvard University, Department of Stem Cell and Regenerative Biology, 185 Cambridge Street CPZN 4234, Boston, MA 02114, USA National Research Institute for Child Health and Development, Department of Reproductive Biology Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, 1300 York Avenue, New York, NY 10065, USA Department of Animal Ecology and Tropical Biology, Biocenter, University of Wu¨ rzburg, Am Hubland, 97074 Wu¨ rzburg Agroecology, Department of Crop Sciences, Georg-August University, Grisebachstr. 6, 37077 Go¨ttingen, Germany Department of Histopathology, Ealing Hospital NHS Trust, London, UK Department of Dermatology, Ealing Hospital NHS Trust, London, UK Moorfields Eye Hospital, City Road, London EC1V 2PD School of Geography, Earth & Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK Centre for Immunity, Infection and Evolution, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, Edinburgh EH9 3JT, UK Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213 Niagara Family Medicine Associates and NF Memorial Medical Center, Niagara Falls, NY, USA UB Patient Safety Research Center, School of Medicine and Biomedical Sciences, State University at Buffalo, NY, USA Holark Systems, Buffalo, NY, USA Department of Biochemistry, University of Illinois, 600 South Mathews Avenue, Urbana-Champaign, IL 61801, USA Department of Molecular, Cellular, and Developmental Biology, Yale University, 165 Prospect Street, OML 352A, New Haven, CT 06520, USA Department of Plant Molecular Genetics, Centro Nacional de Biotecnología-CSIC, Darwin 3, Campus UAM, Cantoblanco, Madrid, 28049, Spain Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9127, USA Minneapolis Heart Institute Foundation, 920 East 28th Street, Suite 300, Minneapolis, MN 55407, USA St Jude Medical, Sylmar, CA, USA Galichia Heart Hospital, 2600 N. 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Buzzati-Traverso, CNR, Naples 80131, Italy Telethon Institute of Genetics and Medicine, Napoli, Italy Department of Structural and Functional Biology, University of Naples 'Federico II', Naples, Italy Medical Genetics Unit, Children' s Hospital Anna Meyer, Firenze, Italy Department of Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA Stowers Institute for Medical Research, Kansas City, MO 64110, USA Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520-8040, USA Percy FitzPatrick Institute, DST/NRF Centre of Excellence, University of Cape Town, Rondebosch, Cape Town 7701, South Africa Rush University Medical Center, Department of Orthopaedic Surgery, 1653 W Congress Parkway, 1471 Jelke, Chicago, IL 60612, USA University of Newcastle and Newcastle Bone and Joint Institute, Royal Newcastle Centre, Newcastle, NSW 2300, Australia Auckland City Hospital, Auckland, New Zealand Department of Anaesthesiology, University of Auckland, Auckland, New Zealand Division of Medical Oncology, Department of Oncology, Hematology and Respiratory Diseases, University Hospital, University of Modena and Reggio Emilia, Italy Department of Medical Genetics, Rikshospitalet University Hospital, Sognsvannsveien 20, 0027 Oslo, Norway Department of Cardiology, Rikshospitalet University Hospital and University of Oslo, Sognsvannsveien 20, 0027 Oslo, Norway Department of Medicine I, Brandenburg Municipal Hospital, Brandenburg Institute for Research in Myocardial Infarction Ludwigshafen of the University of Heidelberg, Ludwigshafen, Germany Medizinische Klinik und Poliklinik I, Campus Grosshadern, Ludwig-Maximilians-University, Marchioninistr. 15, D-81377 Munich, Germany Department of Pharmacology and Toxicology, Medical Faculty, Dresden University of Technology, Dresden, Germany Department of Cardiology, University of Bonn, Bonn Division of Cardiology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany Department of Cardiology and Angiology, University Hospital Mu¨nster, Mu¨nster Department of Cardiology/Angiology, University Hospital Eppendorf, Hamburg, Germany Institut de Recerca i Tecnologia Agroalimenta`ries (IRTA), Barcelona Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Auto`noma de Barcelona, 08193 Bellaterra, Barcelona, Spain Bone and Cartilage Research Unit, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium Department of Clinical Genetics Guy's & St Thomas' NHS Foundation Trust, Great Maze Pond, London SE1 9RT Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College, UK Medical Research Council, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College, De Crespigny Park, Denmark Hill, London SE5 8AF, UK Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College, Great Maze Pond, London SE1 9RT Department of Internal Medicine and Rheumatology, Justus-Liebig University Giessen, Division of Rheumatology and Clinical Immunology, Kerckhoff Clinic, Benekestrasse 2-8, D-61231 Bad Nauheim, Germany Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, 96 Jonathan Lucas St, Suite 812 CSB, Charleston, SC 29425, USA Department of Medical Endocrinology, PE 2132, Rigshospitalet, National University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA Department of Pathology and Laboratory Medicine, Geisinger Medical Center, 100 N Academy Avenue, Danville, PA 17822, USA Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 50 Staniford Street, Boston, MA 02114, USA Department of Neuropsychiatry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan Department of Pathology, University of Maryland, 22 South Greene Street, Baltimore, MD 21201, USA Marie Curie Early Stage Training Program - 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Stockholm, Sweden Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand Swedish Institute for Communicable Disease Control, Solna, Sweden Travel Clinic, Lääkärikeskus Aava Postitalo, Helsinki, Finland Center for Clinical Research, Sormland County Council, Eskilstuna, Sweden Department of Medicine, University of Helsinki, Finland Karolinska Institutet, Department of Medicine/Huddinge, Unit for Infectious Diseases, Stockholm, Sweden Centre for International Health, School of Medicine, University of Otago, New Zealand Departamento de Gene´tica, Facultad de Veterinaria, Universidad Complutense de Madrid, Avenida Puerta de Hierro s/n, 28040 Madrid, Spain IST, Technical University of Lisbon, 1169-047 Lisbon, Portugal KDBIO Group, INESC-ID, Portugal Unidade de Sistemas Biolo´gicos, Biocant, 3060-197 Cantanhede, Portugal Centro de Neurociˆencias e Biologia Celular, Universidade de Coimbra, 3004-517 Coimbra, Portugal Unidade de Biologia Celular, Biocant, 3060-197 Cantanhede, Portugal Division of Cardiology, Cardiocentro Ticino, Lugano, Switzerland IRCCS Istituto Clinico Humanitas, Via Manzoni 56, Rozzano/Milano, Italy Centre for Cardiovascular Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham School of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK School of Social and Community Medicine, University of Bristol, UK Natural Resources Management Centre, Department of Natural Resources, University of Cranfield, Bedford MK43 0AL, UK Porter Alliance, Department of Biology, Imperial College London, London SW7 2AZ, UK Clinical Research Solutions Inc. , Kitchener, Canada F. Hoffmann-La Roche, Basel, Switzerland Centre Hospitalier Universitaire de Reims, Reims, France Renal Unit OLV, Belgium Hospital Universitario Valdecilla, Santander, Spain Toronto General Hospital, Toronto Eurodial, Dialysis Unit, Leiria, Portugal Nephrology and Dialysis Dept. , S. Maugeri Foundation IRCCS, Pavia, Italy Nephrology Monash Medical Centre, Clayton, Australia Lapeyronie University Hospital, CHU Montpellier, Montpellier, France University of Erlangen Medical Center and KfH Kidney Center, Munchen, Germany Ospedale Alessandro Manzoni, Lecco, Italy Henry Ford Health System, Detroit, USA Department of Pathology, Case Western Reserve University, Cleveland, OH, USA Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan Department of Medicine, University of Louisville, 615 S. Preston St. , Louisville, KY 40202-1718, USA Radiology Department, Metropolitan Hospital, Ethn. Makariou 9 & El. Venizelou 1 Street, Athens, 18547, Greece Radiology Department, KAT Hospital, Nikis 2 Street, Athens, 14561, Greece Department of Orthopaedics, Spine Unit, Metropolitan Hospital, Ethn. Makariou 9 & El. Venizelou 1 Street, Athens, 18547 Institut fu¨r klinische Chemie und klinische Pharmakologie, Universita¨tsklinikum Bonn, Bonn, Germany Universita¨tsklinikum und Poliklinik fu¨r Innere Medizin II, Nephrologie, Rheumatologie und Endokrinologie, Martin Luther Universita¨t Halle-Wittenberg, Germany Klinik fu¨r Innere Medizin III, Kardiologie, Angiologie und internistische Intensivmedizin, Universita¨tsklinikum des Saarlandes, Kirrberger Strasse, Geba¨ude 40, 66421 Homburg/Saar, Germany Royal National Orthopaedic Hospital Trust, Stanmore, UK Orthopaedic Department, Ashford and St Peter's NHS Trust, Chertsey KT16 0PZ, UK Hammersmith Hospital Campus, Department of HPB Surgery, Department of Surgery and Cancer, Imperial College, London W12 0NN University of East Anglia, Norwich, UK Norfolk and Norwich Hospitals - Breast and Endocrine Surgery, Norwich, UK Department of Critical Care Medicine, Aintree University Hospitals NHS Foundation Trust, UK Weaning and Long Term Ventilation Service, Department of Respiratory Medicine, Aintree University Hospitals NHS Foundation Trust, Liverpool L9 7AL, UK Diabetic Foot Clinic, Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich NR4 7UY, UK Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, UK ATR Brain Information Communication Research Laboratory Group, Kyoto 619-0288 Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan CiNet, National Institute of Information and Communications Technology, Kyoto 619-0288, Japan Institute of Botany, University of Hohenheim, Garbenstrasse 30, D-70593 Stuttgart, Germany Northern California Fertility Medical Center, 1130 Conroy Lane, Suite 100, Roseville, CA 95661, USA Gene Security Network, Inc. , 2686 Middlefield Road, Suite C, Redwood City, CA 94063, USA Present address: GigaGen Inc. , 409 Illinois St, San Francisco, CA 94158, USA Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China Public Health Laboratories, Ontario Agency for Health Protection and Promotion, Department of Lab Medicine and Pathobiology, University of Toronto, Toronto, Canada Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Department of Obstetrics and Gynecology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Department of Obstetrics and Gynecology, St Olavs Hospital, Trondheim 7006, Norway Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim 7006 Department of Public Health and General Practice, Faculty of Medicine, NTNU, Norway Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen 5021, Norway Wellcome Trust Sanger Institute, Hinxton, Cambridge C10 1SA, United Kingdom Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine, St Thomas' Hospital, London, UK Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Australia Discipline of Medicine, University of Tasmania, Hobart, Australia Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Australia Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, Australia Department of Biostatistics and Bioinformatics, Duke University Medical Center, USA Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Australia Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH, USA Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki FI-00271, Finland Division of Epidemiology, Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA Prevention and Research Center, The Weinberg Center for Women's Health and Medicine, Mercy Medical Center, Baltimore, MD 21202, USA Department of Epidemiology, American Cancer Society, Atlanta, GA 30303-1002, USA Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA Key Laboratory of Systems and Control, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, People's Republic of China Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA Heartland Assays, Inc. , Ames, Iowa, USA Information Management Services, Rockville, MD Institute of Virology, Freie Universita¨t Berlin, Philippstrasse 13, 10115 Berlin, Germany Laboratoire de Virologie Mole´culaire, UR1282 IASP, INRA Centre de Tours, France Department of Statistics and Probability Theory, University of Technology, Vienna, Austria Division of Gastroenterology and Hepatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria Department of Internal Medicine, Baylor University Medical Center, Dallas, TX, USA Department of Biotechnology, University of Natural Resources and Applied Life Sciences, Vienna, Austria National Institute of Plant Genome Research, Aruna Asaf Ali Marg, PO Box 10531, New Delhi 110067 Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK Dipartimento di Scienze Chirurgiche Specialistiche, Universita` degli Studi di Milano, Milan UO Audiology, Fondazione IRCCS Ca` Granda, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy Institute of Bioinformatics, University of Georgia, Athens, GA, USA Howard Hughes Medical Institute, University of California San Diego, La Jolla, CA 92093, USA Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester M1 7DN, UK Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA Department of Ecology and Evolutionary Biology, Eno Hall, Princeton University, Princeton, NJ 0854, USA Center for Infectious Disease Dynamics, The Pennsylvania State University, 208 Mueller Lab, University Park, PA 16802, USA Mathematical, Computational & Modeling Sciences Center, School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85287-2402, USA The Heart Group, Lancaster PA, USA Medtronic Inc. , Mounts View, MN Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk J3-4, Cleveland, OH 44195, USA Scripps Clinic, La Jolla CA, USA Copenhagen University Hospital Gentofte, Copenhagen, Denmark Queen's University, Kingston, ON, Canada University of Western Ontario, London, ON, Canada School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK Yale University, New Haven, CT 06520-8109, USA Department of Physics and Astronomy, Ohio University, Athens, OH, USA The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada NORDITA, Roslagstullsbacken 23, 10691 Stockholm, Sweden Klinikum Lu¨denscheid, Paulmannsho¨ her Straße 14, 58515 Lu¨denscheid, Germany Westpfalzklinikum GmbH, Hellmut-Hartert Straße 1, 67655 Kaiserslautern, Germany Kings College Hospital, Cardiac Catheter Suite, Level 1, Denmark Hill, SE5 9RS London, UK Medtronic, Inc. , Mounds View Facility South, 8200 Coral Sea Street N. E. , MN 55112, USA Medtronic, Bakken Research Center, Endepolsdomein 5, 6229GW Maastricht, The Netherlands Medical Clinic of University Saarland, Kirrberger Straße, 66424 Homburg/Saar, Germany Klinikum Kreuzschwestern Wels, Grieskirchner Straße 42, 4600 Wels, Austria Barzilai Medical Center, Hahistadrout Street 3, 78306 Ashkelon, Israel Global Medical Affairs and Clinical Research, McNeil AB, Helsingborg, Sweden Dept of Pulmonary Medicine, Gentofte University Hospital, Copenhagen Department of Gerontology and Rehabilitation, St Finbarrs Hospital, Douglas Road, Cork City, Ireland Kidney Disease Section, National Institute of Diabetes, Digestive, and Kidney Disease, National Institutes of Health, Bethesda, MD, USA Wake Forest University School of Medicine, Winston-Salem, NC, USA Laboratory of Genomic Diversity, SAIC-Frederick, Inc, NCI-Frederick, Frederick, MD, USA Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv 69978, Israel Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion - Israel Institute of Technology, Haifa 31096, Israel Molecular Medicine Laboratory, Rambam Health Care Campus, Haifa 31096, Israel Cabrini Medical Center, New York City, NY, USA Laboratory of Genomic Diversity, SAIC-Frederick Inc. , National Cancer Institute, Frederick, MD 21702 Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA Computer Science Department, Technion - Israel Institute of Technology, Haifa 32000 Dipartimento di Specialita` Medico Chirurgiche, Universita` di Padova, Italy Institut fuer Genetik, Rheinische Friedrich-Wilhelms-Universitaet Bonn, Roemerstrasse 164, D-53117 Bonn, Germany Istituto CNR di Neuroscienze, Padova, Italy Dipartimento di Fisica 'G. Galilei', Universita` di Padova, 35131 Padova, Italy Istituto Veneto di Medicina Molecolare, Fondazione per la Ricerca Biomedica Avanzata, 35129 Padova, Italy Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA Consorzio Mario Negri Sud, via Nazionale, 8, Santa Maria Imbaro (CH) 66030, Italy Institute of Genetics and Biophysics (IGB), CNR, via P. Castellino 111, Naples 80131, Italy Center for Genomic Regulation (CRG) and Institucio´ Catalana de Recerca i Estudis Avanc¸ats (ICREA), c/Aiguader, 88, Barcelona 08003, Spain PENN Genome Frontiers Institute, University of Pennsylvania, 301 Lynch Laboratories/ 6018, 433 S. University Avenue, Philadelphia, PA 19104, USA Stem Cell and Regenerative Medicine Center, Department of Neurology, University of Wisconsin, Madison, WI, USA Department of Pathology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA Research Department of Primary Care and Population Health, University College London, London, UK Department of Surgery, Transplantation and Advanced Technologies; Anaesthesia and Intensive Care Unit, University Hospital of Catania, Via Santa Sofia, 86 95123 Catania Department of Surgery, Transplantation and Advanced Technologies; Vascular Surgery and Organ Transplant Unit, University Hospital of Catania, Via Santa Sofia, 86 95123 Catania, Italy Orthopaedic Department, Hippokratio General Hospital of Thessaloniki, Thessaloniki, Greece Boston University, Department of Biology, 5 Cummington Street, Boston, MA 02215, USA Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK Institute for Land, Water and Society, Charles Sturt University, PO Box 789, Albury, New South Wales 2640 INRA, UMR 1225, F-31076 Toulouse, France Cactus Research, Ltd. , 12100 Cactus Feeders Road, Cactus, Texas, 79013 Institute for Animal Health, Neuropathogenesis Unit, West Mains Road, Edinburgh EH9 3JF Robert Koch-Institute, P24-Transmissible Spongiform Encephalopathies, Nordufer 20, D-13353 Berlin Population Health, Division of Applied Health Sciences, University of Aberdeen, Aberdeen , UK Obstetrics and Gynaecology, Division of Applied Health Sciences, University of Aberdeen, Aberdeen , UK Kuster Research and Consulting, 22509 East 1680th Street, Geneseo, Illinois, 61254 Center for Comparative Medicine and Transitional Research, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St. , Raleigh, NC 27606, USA UMR BIPAR ENVA/AFSSA/INRA/UPVM, E´ cole Nationale Ve´te´rinaire d'Alfort, 7 avenue du Ge´ne´ral de Gaulle, 94704 Maisons-Alfort, France Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA Focal Area of Infection Biology Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland Division of Infectious Diseases, University of California, San Francisco, 513 Parnassus Avenue, Room S-380, San Francisco, CA, 94143-0654, USA Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Leahurst, CH64 7TE, United Kingdom Vector-Borne Disease Programme, Institute for Animal Health, Ash Road, Pirbright, Woking, Surrey, GU24 0NF, United Kingdom Bacterial Diseases Branch, Division of Vector-Borne Infectious Disease, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, USA Department of Surgery, Saiseikai Niigata Daini Hospital, Saiseikai , Japan Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia Matematiska Institutionen, Uppsala Universitet, Box 480, 751 06, Uppsala, Sweden Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK INRA, UMR 1300 BIOEPAR, ENVN, Atlanpoˆle - La Chantrerie, BP 40706, F-44307 Nantes Cedex 03 INRA, UMR BIPAR, ENVA, 7 avenue du Ge´ne´ral de Gaulle, 94700 Maisons-Alfort Cedex, France Institut Pasteur, De´partement de Parasitologie et Mycologie, Unite´ Immunophysiologie et Parasitisme Intracellulaire, 25 rue du Dr Roux, 75724 Paris Cedex 15, France Unite´ de Recherche en Maladies Infectieuses et Tropicales E´ mergentes (URMITE), UMR CNRS-IRD 6236, WHO Collaborative Center for Rickettsial diseases and other arthropod-borne bacterial diseases, Faculte´ de Me´decine, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France Department of Animal Science, McGill University, Quebec, Canada Faculty of Veterinary Science, University of Sydney, Private Mail Bag 3, Camden NSW 2570, Australia USDA, APHIS, VS, Centers for Epidemiology and Animal Health, 2150 Centre Avenue, Bldg. B, Mail Stop 2W64, Fort Collins, Colorado, 80526-8117 Present address: UMR 956 INRA/AFSSA/ENVA, AFSSA, 23 avenue du Ge´ne´ral de Gaulle, 94700 Maisons-Alfort, France UMR ENVN, INRA 1300 BIOEPAR, E´ cole Nationale Ve´te´rinaire de Nantes, Interactions Hoˆte-Parasite-Milieu, Atlanpole-La Chantrerie, BP 40706, 44307 Nantes Cedex 03, France Regional Animal Health Centre VI, Ho Chi Minh City School of Veterinary Science, University of Queensland, St. Lucia, Queensland, Australia School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia Current address: Faculty of Veterinary Science, The University of Sydney, Private Mail Bag 3, Camden NSW 2570, Australia Department of Veterinary Integrative Biosciences, Texas A&M University College of Veterinary Medicine & Biomedical Sciences, College Station, TX 77845-4458, USA Department of Veterinary Pathobiology, Texas A&M University College of Veterinary Medicine & Biomedical Sciences, College Station, TX 77845-4458, USA Present address: The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, United Kingdom Faculty of Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom National Veterinary Institute, Technical University of Denmark, 27 Bu¨lowsvej, DK-1790 Copenhagen V, Denmark Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, Via Appia Nuova 1411, 00178 Rome, Italy Istituto Superiore di Sanita`, Viale Regina Elena 299, 00161 Rome, Italy Department of Radiology, Queens Medical Centre, Nottingham Universities NHS Trust, Nottingham NG7 2UH, UK Department of Histopathology, Queens Medical Centre, Nottingham Universities NHS Trust Department of Colorectal Surgery, Queens Medical Centre, Nottingham Universities NHS Trust, Nottingham NG7 2UH, UK Infectious Diseases Network for Treatment and Research in Africa, Kampala, Uganda Department of Pharmacology and Therapeutics, Trinity College, Dublin, Ireland Infectious Diseases Institute, Makerere University, Kampala, Uganda Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, UK Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Department of Chemistry, Faculty of Science, Makerere University, Kampala, Uganda Makerere University-Johns Hopkins University Research Laboratory, Kampala, Uganda Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, Amsterdam, The Netherlands Department of Molecular Genetics and Microbiology, Howard Hughes Medical Institute, Duke University Medical Center, United States of America School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh Biochemistry Department, Faculty of Medicine, Sultan Qaboos University, Alkhod, PO Box 35, Muscat, Oman Department of Biochemistry, Faculty of Medicine, University of Khartoum, Khartoum, Sudan Stem Cell Biology Unit, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, D-37077 Go¨ ttingen, Germany MATI Center of Excellence, University of Udine, 33100 Udine, Italy Department of Medicine, Musgrove Park Hospital Aptalis Pharma (formerly Eurand, Inc. ) R & D, Vandalia, OH 45377, US Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), 2-43-17F Aomi, Koutou-ku, Tokyo 135-0064, Japan Institute of Life Sciences, Ajinomoto Co. , Inc, 1-1 Suzuki-cho, Kawasaki- ku, Kawasaki-shi 210-8681 Az. Ospedaliera S. Maria della Misericordia, Udine, Italy S. Maria Nuova Hospital, Reggio Emilia, Italy Department of Cardiology, IRCCS Istituto Clinico Humanitas, Via Manzoni, 56, Rozzano (MI) IT-2089, Italy Villa Maria Eleonora S. r. l. , Palermo, Italy Azienda Ospedaliera Universitaria, Parma, Italy Villa S. Anna S. p. A. , Catanzaro, Italy Policlinico San Matteo, Pavia, Italy Policlinico Sant'Orsola-Malpighi, Bologna, Italy Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK Medtronic Inc. , Maastricht, The Netherlands Department of Cardiology, University of Birmingham, Good Hope Hospital, Heart of England NHS Trust, Rectory Road, Sutton Coldfield, West Midlands B75 7RR, UK Queen Elizabeth Hospital, University of Birmingham, Birmingham, UK Department of Biochemistry, Good Hope Hospital, Heart of England NHS Trust, Sutton Coldfield, West Midlands, UK Department of Biology, Unit of General and Systematic Botany, Pisa University, Via L. Ghini 5, I-56126 Pisa, Italy Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB Department of Biology, College of William and Mary, Williamsburg, VA 23187, USA Life Sciences, University of Manchester, Manchester M13 9PT, UK Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA Service of Pathology, San Paolo University Hospital, Milan, Italy Unit of Neuromuscular Diseases, IRCCS Foundation Neurological Institute 'C. Besta', Milan, Italy Department of Medical and Surgical Sciences, University of Padova School of Medicine, Padova, Italy Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA INRA, UMR 1300 BioEpAR, ENVN, Atlanpoˆle - La Chantrerie, BP 40706, F-44307 Nantes Cedex 03, France Present address: Department of Anesthesiology, Duke University Medical Center, Durham NC 27710, USA Institute for Immunology, Steinbeis Transfercenter for Proteome Analysis, Core Facility for Transcriptome Analysis, Schillingalle 70, 18055 Rostock, Germany Research Institute for the Biology of Farm Animals (FBN), Molecular Biology Research Unit, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany AgResearch, New Zealand University of Veterinary Medicine, Immunology Unit, Bischofsholer Damm 15, 30173 Hannover, Germany Fisheries Laboratory, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bentenjima, Maisaka, Hamamatsu, Shizuoka 431-0214, Japan School of Marine Biosciences, Kitasato University, Okirai, Sanriku, Ofunato, Iwate 022-0101, Japan Faculty of Marine Bioscience, Fukui Prefectural University, Obama, Fukui 917-0003, Japan Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Higashi 1-1-1, Tsukuba, Ibaraki 305-8566, Japan Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Higashi- Nijo 17-2-1, Tsukisamu, Sapporo, Hokkaido 062-8517, Japan Department of Pathology, Emory University School of Medicine, Whitehead Bldg. 105D, 615 Michael St. , Atlanta, GA 30322, USA Research Center for Allergy and Immunology (RCAI), RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama 230-0045, Japan Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan The Roslin Institute and Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK Department of Bioresources, National Institute for Basic Biology, Okazaki, Aichi 444-8585, Japan Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore Department of Pediatrics, University of Washington, Seattle, WA, USA Molecular Genetics Unit, National Institute in Aging, National Institutes of Health, Bethesda, MD, USA Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA Genetic Health Services Victoria, Melbourne, Australia Australian Genome Research Facility, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne Wessex Renal and Transplant Research Unit, Queen Alexandra Hospital, Cosham, Portsmouth PO6 3LY, UK Division of Infection, Inflammation and Immunity, Mailpoint 813, University of Southampton Medical School, Sir Henry Wellcome Laboratories, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America, 2 Department of Chemistry, Stanford University School of Humanities and Sciences, Stanford, California, United States of America School of Biological Sciences, Queen's University Belfast, Belfast BT7 1NN, Northern Ireland, UK Department of Biology, Kobe University, Japan ESPN/ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Nephrology, Dialysis and Transplantation Unit, G Gaslini Institute, Genoa, Italy Department of Paediatric Nephrology, Bristol Royal Hospital for Children, Bristol, UK Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK School of Biosciences, University of Birmingham, Edgbaston Park Road, Birmingham B15 2TT, UK Institute of Biotechnology 1, Forschungszentrum Julich GmbH, D-52425 Julich Bijvoet-Center for Biomolecular Research, University of Utrecht, Utrecht Core Facility, Molecular Structure Analysis, German Cancer Research Center, Heidelberg, Germany Organic Chemistry, Stockholm University, Stockholm, Sweden Division of Molecular Biosciences, Faculty of Natural Sciences, Biochemistry Building, Imperial College London, South Kensington Campus, London SW7 2AZ, UK Department of Biochemistry, Oxford Glycobiology Institute, University of Oxford, UK Dublin- Oxford Glycobiology Laboratory, National Institute for Bioprocessing Research and Training (NIBRT), Conway Institute, University College Dublin, Dublin, Ireland Institute of Biochemistry, Faculty of Medicine, Justus, Liebig University, Giessen, Germany Department of Pharmaceutical Science, University of Basel, Basel Switzerland Institute for Medical Informatics, Section of Medical Statistics, Justus-Liebig-University Giessen, Heinrich-Buff Ring 44, D-35392 Giessen, Germany Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, Justus-Liebig-University Giessen, Rudolf-Buchheim-Str. 7, D-35385 Giessen, Germany Department of Medicine II, University of Giessen Lung Center, Aulweg 123, D-35392 Giessen, Germany Comprehensive Pneumology Center, Ludwig-Maximilians-University, Asklepios Hospital, and Helmholtz Zentrum München, Ingolstädter Landstr 1, D-85764 Neuherberg/München, Germany Fred Hutchinson Cancer Research Center, Seattle, WA 98109 Department of Oncology, Oslo University Hospital, N-0407 Oslo, Norway Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, N-9037 Tromsø, Norway Department of Microbiology and Infection Control, University Hospital North Norway, N-9038 Tromsø, Norway Department of Epidemiology and Population Studies, Medical College, 31-531 Krakow, Poland Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA Department of Clinical Science, Obstetrics and Gynecology, Umea˚ University, Umea˚, Sweden Department of Public Health and Clinical Medicine, Umea˚ University Hospital, Umea˚, Sweden Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden Vitrolife Sweden AB, Go¨ teborg, Sweden Department of Obstetrics and Gynaecology, Go¨ teborg University, SE-413 45 Go¨ teborg, Sweden IVF Research Sweden AB, Gothenburg, Sweden IVF-kliniken Falun, Falu Hospital, Falun, Sweden Fertilitetsenheten, Karolinska University Hospital, Huddinge, Stockholm, Sweden Reproduktionsmedicinsk Centrum, University Hospital, Malmo¨ , Sweden Department of Animal and Plant Sciences, University of Sheffield, Alfred Denny Building, Western Bank, Sheffield S10 2TN, UK Emeritus Professor of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria 3010, Australia Health Policy Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK KEMRI/Wellcome Trust Research Programme, PO Box 43640-00100 Nairobi, Kenya Institute of Health Policy and Management, Erasmus University Rotterdam Department of Physics and Astronomy, University College London, London WC1E 6BT Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK Biomedical Sciences Research Complex and EaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK